Gene
hesx1
- ID
- ZDB-GENE-990415-130
- Name
- HESX homeobox 1
- Symbol
- hesx1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have identical protein binding activity and sequence-specific DNA binding activity. Involved in forebrain development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in septooptic dysplasia. Is expressed in anterior presumptive neural plate; neural keel; neural plate; and telencephalon. Orthologous to human HESX1 (HESX homeobox 1).
- Genome Resources
-
- Alliance (1)
- Gene:30620 (1)
- VEGA:OTTDARG00000043106 (1)
- Note
-
There is no gene model for hesx1 in Ensembl GRCz11. The hesx1 transcript is incorrectly assigned to appl1.
- Comparative Information
-
- All Expression Data
- 27 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
-
- eu608 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Young et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| septooptic dysplasia | Alliance | Growth hormone deficiency with pituitary anomalies | 182230 |
| septooptic dysplasia | Alliance | Pituitary hormone deficiency, combined, 5 | 182230 |
| septooptic dysplasia | Alliance | Septooptic dysplasia | 182230 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox expressed in ES cells 1 | Homeodomain |
|---|---|---|---|---|---|
|
UniProtKB:P79738
|
161 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance