Gene

hesx1

ID
ZDB-GENE-990415-130
Name
HESX homeobox 1
Symbol
hesx1 Nomenclature History
Previous Names
  • anf1 (1)
  • Anf (1)
  • anterior neural folds homolog
  • danf (1)
  • zanf
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within forebrain development. Predicted to be located in early endosome membrane; phagocytic vesicle; and ruffle. Predicted to be active in nucleus. Is expressed in anterior presumptive neural plate; neural keel; neural plate; and telencephalon. Human ortholog(s) of this gene implicated in septooptic dysplasia. Orthologous to human HESX1 (HESX homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
27 figures from 19 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Young et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hesx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
septooptic dysplasia Alliance Growth hormone deficiency with pituitary anomalies 182230
septooptic dysplasia Alliance Pituitary hormone deficiency, combined, 5 182230
septooptic dysplasia Alliance Septooptic dysplasia 182230
Associated With hesx1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR006020 PTB/PI domain
Domain IPR037929 APPL1, BAR domain
Family IPR043402 Homeobox expressed in ES cells 1
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR027267 AH/BAR domain superfamily
Domain Details Per Protein
Protein Length AH/BAR domain superfamily APPL1, BAR domain Homeobox, conserved site Homeobox domain Homeobox expressed in ES cells 1 Homeobox-like domain superfamily PH-like domain superfamily Pleckstrin homology domain PTB/PI domain
UniProtKB:F1QBG1 72
UniProtKB:P79738 161
UniProtKB:B3DGX6 161
UniProtKB:A0A2R8QM99 718
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations