ZFIN ID: ZDB-LAB-970507-9
Zhiyuan Gong Lab
PI/Director: Gong, Zhiyuan
Contact Person: Gong, Zhiyuan
Email: dbsgzy@nus.edu.sg
Address: Department of Biological Sciences The National University of Singapore 10 Kent Ridge Crescent Singapore 119260 SINGAPORE
Country: Singapore
Phone: 65-687-42860
Fax: 65-677-92486
Line Designation: gz

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In the past few years, our laboratory has employed the transgenic technology in two small model aquarium fish, the zebrafish (Danio rerio) and medaka (Oryzias latipes), for various applications including generation of fluorescent ornamental fish, biomonitoring fish, bioreactor fish and oncofish. So far we have successfully generated many lines of fluorescent transgenic zebrafish and medaka with several different colors and some of the transgenic fish are being marketed in USA as the first transgenic pet. We also developed transgenic lines in response to estrogenic compounds and/or other toxical chemicals. As our transgenic system allows us to express foreign proteins up to 17% of total muscle proteins, currently we are testing the concept using transgenic fish as a bioreactor to produce useful proteins. Other transgenic applications include generation of tissue-specific living color transgenic lines for developmental analysis, conditional transgenesis, germline excision of transgene, transgenic oncofish, etc.

In 2002, several zebrafish laboratories in National University of Singapore, Genome Institute of Singapore and Institute of Cell and Molecular Biology have initiated a Zebrafish Liver Program funded by Biomedical Research Council of Singapore. In this program, we are using the zebrafish model to investigate molecular mechanisms of liver development and carcinogenesis. There are three major areas in this program: 1) Zebrafish liver genomics:  we are developing zebrafish genomic tools including large scale of full length cDNA sequencing and microarray technology, and using these tools to analyze global expression profile during zebrafish liver development and carcinogenesis; we are also developing zebrafish DNA chips for environmental monitoring. 2) Zebrafish models for human liver cancers: we are generating zebrafish tumors both by carcinogen treatment and by transgenic approach using some well characterized candidate oncogenes such as c-myc, ras, etc.; microarray technology is also used to compare the set of genes in response to carcinogenesis between zebrafish and human and thus providing insight into the molecular mechanism of carcinogenesis. 3) Zebrafish liver development: zebrafish liver development will be examined by several different approaches, including characterization of liver development in both wild type and mutant embryos, establishment of a liver-GFP transgenic model, identification of growth factors and transcription factors important in liver development, and screening of small molecules capable of modulation of liver development. As a leading laboratory in this program, we are actively involved in essentially all of the proposed projects in the Zebrafish Liver Program.

Korzh, Svitlana Post-Doc Lam, Siew Hong Post-Doc Pan, Xiufang Post-Doc
Zeng, Zhiqiang Post-Doc Hu, Jing Graduate Student Ke, Zhiyuan Graduate Student
Li, Zhen Graduate Student Liu, Xingjun Graduate Student Thakur, Prakash Chandra Graduate Student
Xu, Xiaoming Graduate Student Zhan, Huiqing Graduate Student Mudumana, Sudha Puttur Research Staff
Qing, Wei Research Staff Tong, Yan Research Staff Wu, Yi Lian Research Staff
Yan, Tie Research Staff

Yan, C., Yang, Q., Huo, X., Li, H., Zhou, L., Gong, Z. (2023) Retraction Note: Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Scientific Reports. 13:2103121031
Wang, Y., Wang, J., Cong, J., Zhang, H., Gong, Z., Sun, H., Wang, L., Duan, Z. (2023) Nanoplastics induce neuroexcitatory symptoms in zebrafish (Danio rerio) larvae through a manner contrary to Parkinsonian's way in proteomics. The Science of the total environment. 905:166898
Yang, Q., Yan, C., Gong, Z. (2023) Author Correction: Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish. Scientific Reports. 13:88258825
Duan, Z., Wang, J., Zhang, H., Wang, Y., Chen, Y., Cong, J., Gong, Z., Sun, H., Wang, L. (2023) Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: A case study during zebrafish (Danio rerio) development. Journal of hazardous materials. 458:131679131679
Nakayama, J., Makinoshima, H., Gong, Z. (2023) In vivo Drug Screening to Identify Anti-metastatic Drugs in Twist1a-ERT2 Transgenic Zebrafish. Bio-protocol. 13:e4673e4673
Tan, M.T.H., Gong, Z., Li, D. (2023) Use of Zebrafish Embryos To Reproduce Human Norovirus and To Evaluate Human Norovirus Infectivity Decay after UV Treatment. Applied and environmental microbiology. 89(4):e0011523
Zhang, C., Ren, Z., Gong, Z. (2023) Generation of Albino Phenotype in Ornamental Fish by CRISPR/Cas9-Mediated Genome Editing of slc45a2 Gene. Marine biotechnology (New York, N.Y.). 25(2):281-290
Morgan, K.J., Doggett, K., Geng, F., Mieruszynski, S., Whitehead, L., Smith, K.A., Hogan, B.M., Simons, C., Baillie, G.J., Molania, R., Papenfuss, A.T., Hall, T.E., Ober, E.A., Stainier, D.Y.R., Gong, Z., Heath, J.K. (2023) ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma. eLIFE. 12:
Zhong, Y., Zhang, N., Zhao, F., Chang, S., Chen, W., Cao, Q., Sun, L., Wang, Y., Gong, Z., Lu, L., Liu, D., Yang, L. (2022) RBFOX1 and Working Memory: From Genome to Transcriptome Revealed Posttranscriptional Mechanism Separate From Attention-Deficit/Hyperactivity Disorder. Biological psychiatry global open science. 3:104210521042-1052
Li, Y., Lee, A.Q., Lu, Z., Sun, Y., Lu, J.W., Ren, Z., Zhang, N., Liu, D., Gong, Z. (2022) Systematic Characterization of the Disruption of Intestine during Liver Tumor Progression in the xmrk Oncogene Transgenic Zebrafish Model. Cells. 11(11)
Amanda, S., Tan, T.K., Ong, J.Z.L., Theardy, M.S., Wong, R.W.J., Huang, X.Z., Ali, M.Z., Li, Y., Gong, Z., Inagaki, H., Foo, E.Y., Pang, B., Tan, S.Y., Iida, S., Sanda, T. (2022) IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma. Nature communications. 13:2420
Monroe, J.D., Fraher, D., Huang, X., Mellett, N.A., Meikle, P.J., Sinclair, A.J., Lirette, S.T., Maihle, N.J., Gong, Z., Gibert, Y. (2022) Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish. Cancer & metabolism. 10:7
Chen, S., Wu, J., Li, M., Sun, Q., Gong, Z., Letcher, R.J., Liu, C. (2022) A high-throughput screening assay for identification of chemicals with liver tumor promoting potential using a transgenic zebrafish line. Chemosphere. 297:134169
Duan, Z., Cheng, H., Duan, X., Zhang, H., Wang, Y., Gong, Z., Zhang, H., Sun, H., Wang, L. (2022) Diet preference of zebrafish (Danio rerio) for bio-based polylactic acid microplastics and induced intestinal damage and microbiota dysbiosis. Journal of hazardous materials. 429:128332
Lu, J.W., Lin, L.I., Sun, Y., Liu, D., Gong, Z. (2022) Effect of Lipopolysaccharides on Liver Tumor Metastasis of twist1a/krasV12 Double Transgenic Zebrafish. Biomedicines. 10(1):
Nakayama, J., Tan, L., Li, Y., Goh, B.C., Wang, S., Makinoshima, H., Gong, Z. (2021) A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis. eLIFE. 10:
Tan, M.T.H., Xue, L., Wang, D., Eshaghi Gorji, M., Li, Y., Gong, Z., Li, D. (2021) The globally re-emerging norovirus GII.2 manifests higher heat resistance than norovirus GII.4 and Tulane virus. Journal of applied microbiology. 132(3):2441-2449
Lee, A.Q., Li, Y., Gong, Z. (2021) Inducible Liver Cancer Models in Transgenic Zebrafish to Investigate Cancer Biology. Cancers. 13(20):
Lu, J.W., Sun, Y., Lin, L.I., Liu, D., Gong, Z. (2021) Exacerbation of Liver Tumor Metastasis in twist1a+/xmrk+ Double Transgenic Zebrafish following Lipopolysaccharide or Dextran Sulphate Sodium Exposure. Pharmaceuticals (Basel, Switzerland). 14(9):
Lu, J.W., Sun, Y., Fong, P.A., Lin, L.I., Liu, D., Gong, Z. (2021) Lipopolysaccharides Enhance Epithelial Hyperplasia and Tubular Adenoma in Intestine-Specific Expression of krasV12 in Transgenic Zebrafish. Biomedicines. 9(8):
Helal, M., Yan, C., Gong, Z. (2021) Author Correction: Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model. Scientific Reports. 11:13223
Korzh, S., Winata, C.L., Gong, Z., Korzh, V. (2021) The development of zebrafish pancreas affected by deficiency of Hedgehog signaling. Gene expression patterns : GEP. 41:119185
Lai, K.P., Gong, Z., Tse, W.K.F. (2021) Zebrafish as the toxicant screening model: Transgenic and omics approaches. Aquatic toxicology (Amsterdam, Netherlands). 234:105813
Tan, M.T.H., Li, Y., Eshaghi Gorji, M., Gong, Z., Li, D. (2021) Fucoidan But Not 2'-Fucosyllactose Inhibits Human Norovirus Replication in Zebrafish Larvae. Viruses. 13(3):
Zhu, Y., Yang, D., Duan, X., Zhang, Y., Chen, D., Gong, Z., Liu, C. (2021) Perfluorooctane Sulfonate Promotes Doxycycline-induced Liver Tumor Progression in Male Krasv12 Transgenic Zebrafish. Environmental research. 196:110962
Fu, J., Gong, Z., Bae, S. (2021) Ecotoxicogenomic analysis of zebrafish embryos exposed to triclosan and mixture triclosan and methyl triclosan using suppression subtractive hybridization and next-generation sequencing. Journal of hazardous materials. 414:125450
Helal, M., Yan, C., Gong, Z. (2021) Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model. Scientific Reports. 11:1372
Li, Z., Li, Y., Yang, Y., Gong, Z., Zhu, H., Qian, Y. (2020) In vivo tracking cystine/glutamate antiporter-mediated cysteine/cystine pool under ferroptosis. Analytica chimica acta. 1125:66-75
Johansson, J.A., Marie, K.L., Lu, Y., Brombin, A., Santoriello, C., Zeng, Z., Zich, J., Gautier, P., von Kriegsheim, A., Brunsdon, H., Wheeler, A.P., Dreger, M., Houston, D.R., Dooley, C.M., Sims, A.H., Busch-Nentwich, E.M., Zon, L.I., Illingworth, R.S., Patton, E.E. (2020) PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation. Developmental Cell. 54(3):317-332.e9
Duan, Z., Duan, X., Zhao, S., Wang, X., Wang, J., Liu, Y., Peng, Y., Gong, Z., Wang, L. (2020) Barrier function of zebrafish embryonic chorions against microplastics and nanoplastics and its impact on embryo development. Journal of hazardous materials. 395:122621
Chen, C., Lu, M., Lin, S., Qin, W. (2020) The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond-Blackfan anemia. Cell Death & Disease. 11:135
Chen, S., Gong, Z., Letcher, R.J., Liu, C. (2020) Promotion effect of liver tumor progression in male kras transgenic zebrafish induced by tris (1, 3-dichloro-2-propyl) phosphate. Ecotoxicology and environmental safety. 191:110220
Bai, H., Liu, L., An, K., Lu, X., Harrison, M., Zhao, Y., Yan, R., Lu, Z., Li, S., Lin, S., Liang, F., Qin, W. (2020) CRISPR/Cas9-mediated precise genome modification by a long ssDNA template in zebrafish. BMC Genomics. 21:67
Li, S., Song, D., Huang, W., Li, Z., Liu, Z. (2020) In-situ Imaging of Cysteine in the Brains of Mice with Epilepsy by a Near-infrared Emissive Fluorescent Probe. Analytical chemistry. 92(3):2802-2808
Fu, J., Tan, Y.X.R., Gong, Z., Bae, S. (2019) The toxic effect of triclosan and methyl-triclosan on biological pathways revealed by metabolomics and gene expression in zebrafish embryos. Ecotoxicology and environmental safety. 189:110039
Nakayama, J., Lu, J.W., Makinoshima, H., Gong, Z. (2019) A novel zebrafish model of metastasis identifies the HSD11β1 inhibitor Adrenosterone as a suppressor of epithelial-mesenchymal transition and metastatic dissemination. Molecular cancer research : MCR. 18(3):477-487
Chen, C., Huang, H., Yan, R., Lin, S., Qin, W. (2019) Loss of rps9 in Zebrafish Leads to p53-Dependent Anemia. G3 (Bethesda). 9(12):4149-4157
Chen, S., Dang, Y., Gong, Z., Letcher, R.J., Liu, C. (2019) Progression of liver tumor was promoted by tris(1,3-dichloro-2-propyl) phosphate through the induction of inflammatory responses in krasV12 transgenic zebrafish. Environmental pollution (Barking, Essex : 1987). 255:113315
Li, Y., Agrawal, I., Gong, Z. (2019) Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene transgenic zebrafish model. Disease models & mechanisms. 12(10):
Li, H., Li, Y., Lu, J.W., Huo, X., Gong, Z. (2019) Liver-specific androgen receptor knockout attenuates early liver tumor development in zebrafish. Scientific Reports. 9:10645
Pan, W.Q., Wang, J.P., Tu, Z.H., Gan, T., Hu, J., Wei, J., Leng, X.J., Li, X.Q. (2019) Cloning, molecular characterization, and tissue differential expression of connective tissue growth factor (ctgf) of grass carp. Fish physiology and biochemistry. 45(4):1431-1443
Li, H., Lu, J.W., Huo, X., Li, Y., Li, Z., Gong, Z. (2019) Effects of sex hormones on liver tumor progression and regression in Myc/xmrk double oncogene transgenic zebrafish. General and comparative endocrinology. 277:112-121
Yang, Q., Salim, L., Yan, C., Gong, Z. (2019) Rapid Analysis of Effects of Environmental Toxicants on Tumorigenesis and Inflammation Using a Transgenic Zebrafish Model for Liver Cancer. Marine biotechnology (New York, N.Y.). 21(3):396-405
Huo, X., Li, H., Li, Z., Yan, C., Mathavan, S., Liu, J., Gong, Z. (2019) Transcriptomic analyses of oncogenic hepatocytes reveal common and different molecular pathways of hepatocarcinogenesis in different developmental stages and genders in krasG12V transgenic zebrafish. Biochemical and Biophysical Research Communications. 510(4):558-564
Huo, X., Li, H., Li, Z., Yan, C., Agrawal, I., Mathavan, S., Liu, J., Gong, Z. (2019) Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Scientific Reports. 9:1509
Yang, Q., Yan, C., Wang, X., Gong, Z. (2019) Leptin induces muscle wasting in kras-driven hepatocellular carcinoma (HCC) model in zebrafish. Disease models & mechanisms. 12(2):
Fu, J., Gong, Z., Bae, S. (2019) Assessment of the effect of methyl-triclosan and its mixture with triclosan on developing zebrafish (Danio rerio) embryos using mass spectrometry-based metabolomics. Journal of hazardous materials. 368:186-196
Wen, X.Y., Tarailo-Graovac, M., Brand-Arzamendi, K., Willems, A., Rakic, B., Huijben, K., Da Silva, A., Pan, X., El-Rass, S., Ng, R., Selby, K., Philip, A.M., Yun, J., Ye, X.C., Ross, C.J., Lehman, A.M., Zijlstra, F., Bakar, A.A., Drögemöller, B., Moreland, J., Wasserman, W.W., Vallance, H., van Scherpenzeel, M., Karbassi, F., Hoskings, M., Engelke, U., de Brouwer, A., Wevers, R.A., Pshezhetsky, A.V., van Karnebeek, C.D., Lefeber, D.J. (2018) Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function. JCI insight. 3(24):
Yan, C., Yang, Q., Gong, Z. (2018) Transgenic expression of tgfb1a induces hepatic inflammation, fibrosis and metastasis in zebrafish. Biochemical and Biophysical Research Communications. 509(1):175-181
Lu, J.W., Raghuram, D., Fong, P.A., Gong, Z. (2018) Inducible Intestine-Specific Expression of krasV12 Triggers Intestinal Tumorigenesis In Transgenic Zebrafish.. Neoplasia (New York, N.Y.). 20:1187-1197
Mishra, P., Gong, Z., Kelly, B.C. (2018) Assessing pH-dependent toxicity of fluoxetine in embryonic zebrafish using mass spectrometry-based metabolomics. The Science of the total environment. 650:2731-2741
Yao, Y., Sun, S., Wang, J., Fei, F., Dong, Z., Ke, A.W., He, R., Wang, L., Zhang, L., Ji, M.B., Li, Q., Yu, M., Shi, G.M., Fan, J., Gong, Z., Wang, X. (2018) Canonical Wnt signaling remodels lipid metabolism in zebrafish hepatocytes following Ras oncogenic insult. Cancer research. 78(19):5548-5560
Xu, H., Zhang, X., Li, H., Li, C., Huo, X.J., Hou, L.P., Gong, Z. (2018) Immune response induced by major environmental pollutants through altering neutrophils in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 201:99-108
Yang, Q., Yan, C., Gong, Z. (2018) Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish. Scientific Reports. 8:8495
Chen, H., Sheng, L., Gong, Z., Ru, S., Bian, H. (2018) Investigation of the molecular mechanisms of hepatic injury upon naphthalene exposure in zebrafish (Danio rerio). Ecotoxicology (London, England). 27(6):650-660
Yan, C., Yang, Q., Gong, Z. (2018) Activation of Hepatic Stellate Cells During Liver Carcinogenesis Requires Fibrinogen/Integrin αvβ5 in Zebrafish. Neoplasia (New York, N.Y.). 20:533-542
Leong, W.Z., Tan, S.H., Ngoc, P.C.T., Amanda, S., Yam, A.W.Y., Liau, W.S., Gong, Z., Lawton, L.N., Tenen, D.G., Sanda, T. (2018) ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Genes & Development. 31(23-24):2343-2360
Lee, Y.M., Li, C., Lam, S.H., Gong, Z., Lin, Q. (2018) Proteomic Analysis of Zebrafish (Danio rerio) After Chemical Exposure. Methods in molecular biology (Clifton, N.J.). 1797:443-459
Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44
Mishra, P., Gong, Z., Kelly, B.C. (2017) Assessing biological effects of fluoxetine in developing zebrafish embryos using gas chromatography-mass spectrometry based metabolomics. Chemosphere. 188:157-167
Xu, H., Li, C., Suklai, P., Zeng, Q., Chong, R., Gong, Z. (2017) Differential sensitivities to dioxin-like compounds PCB 126 and PeCDF between Tg(cyp1a:gfp) transgenic medaka and zebrafish larvae. Chemosphere. 192:24-30
Chen, F., Gong, Z., Kelly, B.C. (2017) Bioaccumulation behavior of pharmaceuticals and personal care products in adult zebrafish (Danio Rerio): influence of physical-chemical properties and biotransformation. Environmental science & technology. 51(19):11085-11095
Zhou, H., George, S., Li, C., Gurusamy, S., Sun, X., Gong, Z., Qian, H. (2017) Combined toxicity of prevalent mycotoxins studied in fish cell line and zebrafish larvae revealed that type of interactions is dose-dependent. Aquatic toxicology (Amsterdam, Netherlands). 193:60-71
Yang, Q., Yan, C., Gong, Z. (2017) Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish. Scientific Reports. 7:10315
Liu, X., Li, Y.S., Shinton, S.A., Rhodes, J., Tang, L., Feng, H., Jette, C.A., Look, A.T., Hayakawa, K., Hardy, R.R. (2017) Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. Journal of immunology (Baltimore, Md. : 1950). 199(5):1706-1715
Yan, C., Yang, Q., Shen, H.M., Spitsbergen, J.M., Gong, Z. (2017) Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish.. Oncotarget. 8:77096-77109
Liau, W.S., Tan, S.H., Ngoc, P.C., Wang, C.Q., Tergaonkar, V., Feng, H., Gong, Z., Osato, M., Look, A.T., Sanda, T. (2017) Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia. 31(8):1798-1807
Hou, H.A., Lu, J.W., Lin, T.Y., Tsai, C.H., Chou, W.C., Lin, C.C., Kuo, Y.Y., Liu, C.Y., Tseng, M.H., Chiang, Y.C., Peng, Y.L., Tang, J.L., Gong, Z., Lin, L.I., Tien, H.F. (2017) Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia. Blood cancer journal. 7:e588
Pant, S., Li, C., Gong, Z., Chen, N. (2017) Line-scan focal modulation microscopy. Journal of Biomedical Optics. 22:50502
Yan, C., Yang, Q., Huo, X., Li, H., Zhou, L., Gong, Z. (2017) RETRACTED: Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish.. Scientific Reports. 7:45796
Chen, Q., Li, C., Gong, Z., Chan, E.C., Snyder, S.A., Lam, S.H. (2017) Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 172:429-439
Yan, C., Yang, Q., Gong, Z. (2017) Tumor-associated neutrophils and macrophages promote gender disparity in hepatocellular carcinoma in zebrafish. Cancer research. 77(6):1395-1407
Li, Y., Li, H., Spitsbergen, J.M., Gong, Z. (2017) Males develop faster and more severe hepatocellular carcinoma than females in krasV12 transgenic zebrafish.. Scientific Reports. 7:41280
Yang, Q., Yan, C., Yin, C., Gong, Z. (2017) Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma. Cellular and molecular gastroenterology and hepatology. 3:484-499
Chen, F., Gong, Z., Kelly, B.C. (2016) Bioavailability and bioconcentration potential of perfluoroalkyl-phosphinic and -phosphonic acids in zebrafish (Danio rerio): Comparison to perfluorocarboxylates and perfluorosulfonates. The Science of the total environment. 568:33-41
Zhao, Y., Huang, X., Ding, T.W., Gong, Z. (2016) Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish. Scientific Reports. 6:31952
Lui, E.Y., Li, C., Li, Z.H., Gong, Z., Lam, S.H. (2016) Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. Journal of genetics and genomics = Yi chuan xue bao. 43(8):525-8
Hu, J., Guo, T., Pan, W.Q., Gan, T., Wei, J., Wang, J.P., Leng, X.J., Li, X.Q. (2016) Cloning, molecular characterization, and expression analysis of the unc45 myosin chaperone b(unc45b)gene of grass carp (Ctenopharyngodon idellus). Journal of muscle research and cell motility. 37(3):71-81
Li, C., Tan, X.F., Lim, T.K., Lin, Q., Gong, Z. (2016) Comprehensive and quantitative proteomic analyses of zebrafish plasma reveals conserved protein profiles between genders and between zebrafish and human. Scientific Reports. 6:24329
Li, C., Li, P., Tan, Y.M., Lam, S.H., Chan, E.C., Gong, Z. (2016) Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish. PLoS One. 11:e0151225
Chen, Q., Jia, A., Snyder, S.A., Gong, Z., Lam, S.H. (2016) Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 144:1162-1169
Nguyen, A.T., Koh, V., Spitsbergen, J.M., Gong, Z. (2016) Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras(V12) expression in transgenic zebrafish. Scientific Reports. 6:19559
Liu, C., Su, G., Giesy, J.P., Letcher, R.J., Li, G., Agrawal, I., Li, J., Yu, L., Wang, J., Gong, Z. (2016) Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Scientific Reports. 6:19045
Huang, X., Agrawal, I., Li, Z., Zheng, W., Lin, Q., Gong, Z. (2016) Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery. Advances in experimental medicine and biology. 916:147-68
Wojciechowska, S., Zeng, Z., Lister, J.A., Ceol, C.J., Patton, E.E. (2016) Melanoma Regression and Recurrence in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:143-53
Xu, H., Li, C., Li, Y., Ng, G.H., Liu, C., Zhang, X., Gong, Z. (2015) Generation of Tg(cyp1a:gfp) Transgenic Zebrafish for Development of a Convenient and Sensitive In Vivo Assay for Aryl Hydrocarbon Receptor Activity. Marine biotechnology (New York, N.Y.). 17(6):831-40
Liu, T., Lin, J., Li, Z., Lin, L., Shen, Y., Zhu, H., Qian, Y. (2015) Imaging of living cells and zebrafish in vivo using a ratiometric fluorescent probe for hydrogen sulfide. The Analyst. 140(21):7165-9
Lundegaard, P.R., Anastasaki, C., Grant, N.J., Sillito, R.R., Zich, J., Zeng, Z., Paranthaman, K., Larsen, A.P., Armstrong, J.D., Porteous, D.J., Patton, E.E. (2015) MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish. Chemistry & Biology. 22(10):1335-46
Qin, W., Liang, F., Feng, Y., Bai, H., Yan, R., Li, S., Lin, S. (2015) Expansion of CRISPR/Cas9 genome targeting sites in zebrafish by Csy4-based RNA processing. Cell Research. 25(9):1074-7
Yan, C., Huo, X., Wang, S., Feng, Y., Gong, Z. (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. Journal of hepatology. 63(2):420-8
Seiler, C., Gebhart, N., Zhang, Y., Shinton, S.A., Li, Y.S., Ross, N.L., Liu, X., Li, Q., Bilbee, A.N., Varshney, G.K., LaFave, M.C., Burgess, S.M., Balciuniene, J., Balciunas, D., Hardy, R.R., Kappes, D.J., Wiest, D.L., Rhodes, J. (2015) Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. PLoS One. 10:e0131908
Yan, C., Zheng, W., Gong, Z. (2015) Zebrafish fgf10b has a Complementary Function to fgf10a in Liver and Pancreas Development. Marine biotechnology (New York, N.Y.). 17(2):162-7
Zeng, Z., Johnson, S.L., Lister, J.A., Patton, E.E. (2015) Temperature-sensitive splicing of mitfa by an intron mutation in zebrafish. Pigment cell & melanoma research. 28(2):229-32
Chen, F., Gong, Z., Kelly, B.C. (2015) Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry. Journal of chromatography. A. 1383:104-11
Sun, L., Nguyen, A.T., Spitsbergen, J.M., Gong, Z. (2015) Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation. PLoS One. 10:e0117249
Wang, J., Lee, Y.M., Li, C., Li, P., Li, Z., Lim, T.K., Gong, Z., Lin, Q. (2015) Dramatic improvement of proteomic analysis of zebrafish liver tumor by effective protein extraction with sodium deoxycholate and heat denaturation. International journal of analytical chemistry. 2015:763969
Alli Shaik, A., Wee, S., Li, R.H., Li, Z., Carney, T.J., Mathavan, S., Gunaratne, J. (2014) Functional mapping of the zebrafish early embryo proteome and transcriptome. Journal of Proteome Research. 13(12):5536-50
Terashima, A.V., Mudumana, S.P., Drummond, I.A. (2014) Odd skipped related 1 is a negative feedback regulator of Nodal-induced endoderm development. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(12):1571-80
Tomar, R., Mudumana, S.P., Pathak, N., Hukreide, N.A., Drummond, I.A. (2014) osr1 Is Required for Podocyte Development Downstream of wt1a. Journal of the American Society of Nephrology : JASN. 25(11):2539-45
Chew, T.W., Liu, X.J., Liu, L., Spitsbergen, J.M., Gong, Z., and Low, B.C. (2014) Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models. Oncogene. 33(21):2717-27
Han, Z., Wang, Q., Fu, J., Chen, H., Zhao, Y., Zhou, B., Gong, Z., Wei, S., Li, J., Liu, H., Zhang, X., Liu, C., Yu, H. (2014) Multiple bio-analytical methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate. Aquatic toxicology (Amsterdam, Netherlands). 150:175-81
Zheng, W., Li, Z., Nguyen, A.T., Li, C., Emelyanov, A., Gong, Z. (2014) Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PLoS One. 9:e91179
Zhang, X., Li, C., Gong, Z. (2014) Development of a convenient in vivo hepatotoxin assay using a transgenic zebrafish line with liver-specific DsRed expression. PLoS One. 9:e91874
Pan, X., Sittaramane, V., Gurung, S., and Chandrasekhar, A. (2014) Structural and temporal requirements of Wnt/PCP protein Vangl2 function for convergence and extension movements and facial branchiomotor neuron migration in zebrafish. Mechanisms of Development. 131:1-14
Lister, J.A., Capper, A., Zeng, Z., Mathers, M.E., Richardson, J., Paranthaman, K., Jackson, I.J., and Patton, E.E. (2014) A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo. The Journal of investigative dermatology. 134(1):133-40
Thakur, P.C., Davison, J.M., Stuckenholz, C., Lu, L., and Bahary, N. (2014) Dysregulated phosphatidylinositol signaling promotes endoplasmic reticulum stress-mediated intestinal mucosal injury and inflammation in zebrafish. Disease models & mechanisms. 7(1):93-106
Liu, C., Xu, H., Lam, S.H., and Gong, Z. (2013) Selection of Reliable Biomarkers from PCR Array Analyses Using Relative Distance Computational Model: Methodology and Proof-of-Concept Study. PLoS One. 8(12):e83954
Lam, P.Y., Kamei, C.N., Mangos, S., Mudumana, S., Liu, Y., and Drummond, I.A. (2013) odd-skipped related 2 is required for fin chondrogenesis in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(11):1284-92
Li, Z.H., Xu, H., Zheng, W., Lam, S.H., and Gong, Z. (2013) RNA-Sequencing Analysis of TCDD-Induced Responses in Zebrafish Liver Reveals High Relatedness to In Vivo Mammalian Models and Conserved Biological Pathways. PLoS One. 8(10):e77292
Sittaramane, V., Pan, X., Glasco, D.M., Huang, P., Gurung, S., Bock, A., Li, S., Wang, H., Kawakami, K., Matise, M.P., and Chandrasekhar, A. (2013) The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function. Developmental Biology. 382(2):400-412
Lam, S.H., Ung, C.Y., Hlaing, M.M., Hu, J., Li, Z.H., Mathavan, S., and Gong, Z. (2013) Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: Transcriptomic, histological and targeted gene expression analyses. Biochimica et biophysica acta. General subjects. 1830(10):4778-4789
Fu, J., Han, J., Zhou, B., Gong, Z., Santos, E.M., Huo, X., Zheng, W., Liu, H., Yu, H., and Liu, C. (2013) Toxicogenomic Responses of Zebrafish Embryos/Larvae to Tris(1,3-dichloro-2-propyl) Phosphate (TDCPP) Reveal Possible Molecular Mechanisms of Developmental Toxicity. Environmental science & technology. 47(18):10574-82
Xu, H., Lam, S.H., Shen, Y., and Gong, Z. (2013) Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PLoS One. 8(7):e68737
Gabor, K.A., Stevens, C.R., Pietraszewski, M.J., Gould, T.J., Shim, J., Yoder, J.A., Lam, S.H., Gong, Z., Hess, S.T., and Kim, C.H. (2013) Super Resolution Microscopy Reveals that Caveolin-1 Is Required for Spatial Organization of CRFB1 and Subsequent Antiviral Signaling in Zebrafish. PLoS One. 8(7):e68759
Huang, S.M., Xu, F., Lam, S.H., Gong, Z., and Ong, C.N. (2013) Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry. Molecular Biosystems. 9(6):1372-80
Stuckenholz, C., Lu, L., Thakur, P.C., Choi, T.Y., Shin, D., and Bahary, N. (2013) Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio. PLoS One. 8(4):e62470
Li, Z., Zheng, W., Wang, Z., Zeng, Z., Zhan, H., Li, C., Zhou, L., Yan, C., Spitsbergen, J.M., and Gong, Z. (2013) A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Disease models & mechanisms. 427(1):223-226
Tong, X., Xia, Z., Zu, Y., Telfer, H., Hu, J., Yu, J., Liu, H., Zhang, Q., Sodmergen, D., Lin, S., and Zhang, B. (2013) Ngs (notochord granular surface) encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. The Journal of biological chemistry. 288(4):2711-2720
Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Zhang, L., Li, B., and Gong, Z. (2013) Inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases. PLoS One. 8(2):e56668
Zhang, X., and Gong, Z. (2013) Fluorescent Transgenic Zebrafish Tg(nkx2.2a:mEGFP) Provides a Highly Sensitive Monitoring Tool for Neurotoxins. PLoS One. 8(2):e55474
Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
Chng, H.T., Ho, H.K., Yap, C.W., Lam, S.H., and Chan, E.C. (2012) An Investigation of the Bioactivation Potential and Metabolism Profile of Zebrafish versus Human. Journal of Biomolecular Screening. 17(7):974-986
Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K.L., Temperley, N.D., Johnson, S.L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E.M., Melton, D.W., Smith, T.K., Tyers, M., Westwood, N.J., and Patton, E.E. (2012) ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species. Chemistry & Biology. 19(7):883-892
Cui, J., Sim, T.H., Gong, Z., and Shen, H.M. (2012) Generation of transgenic zebrafish with liver-specific expression of EGFP-Lc3: A new in vivo model for investigation of liver autophagy. Biochemical and Biophysical Research Communications. 422(2):268-273
Choudhury, D., van Noort, D., Iliescu, C., Zheng, B., Poon, K.L., Korzh, S., Korzh, V., and Yu, H. (2012) Fish and Chips: a microfluidic perfusion platform for monitoring zebrafish development. Lab on a Chip. 12(5):892-900
Pavagadhi, S., Gong, Z., Hande, M.P., Dionysioum, D.D., de la Cruz, A.A., and Balasubramanian, R. (2012) Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: A balneation study. Aquatic toxicology (Amsterdam, Netherlands). 109C:1-10
Li, Z., Huang, X., Zhan, H., Zeng, Z., Li, C., Spitsbergen, J.M., Meierjohann, S., Schartl, M., and Gong, Z. (2012) Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish. Journal of hepatology. 56(2):419-425
Yin, A., Korzh, V., and Gong, Z. (2012) Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants. Biochimica et biophysica acta. Molecular cell research. 1823(2):236-244
Huang, X., Zhou, L., and Gong, Z. (2012) Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future oncology (London, England). 8(1):21-28
Nguyen, A.T., Emelyanov, A., Koh, C.H., Spitsbergen, J.M., Parinov, S., and Gong, Z. (2012) An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening. Disease models & mechanisms. 5(1):63-72
Sukardi, H., Zhang, X., Lui, E.Y., Ung, C.Y., Mathavan, S., Gong, Z., and Lam, S.H. (2012) Liver X receptor agonist T0901317 induced liver perturbation in zebrafish: Histological, gene set enrichment and expression analyses. Biochimica et biophysica acta. General subjects. 1820(1):33-43
Zhang, X., Ung, C.Y., Lam, S.H., Ma, J., Chen, Y.Z., Zhang, L., Gong, Z., and Li, B. (2012) Toxicogenomic analysis suggests chemical-induced sexual dimorphism in the expression of metabolic genes in zebrafish liver. PLoS One. 7(12):e51971
Korzh, S., Winata, C.L., Zheng, W., Yang, S., Yin, A., Ingham, P., Korzh, V., and Gong, Z. (2011) The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental Biology. 359(2):262-76
Nguyen, A.T., Emelyanov, A., Koh, C.H., Spitsbergen, J.M., Lam, S.H., Mathavan, S., Parinov, S., and Gong, Z. (2011) A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish. Disease models & mechanisms. 4(6):801-13
He, S., Krens, S.G., Zhan, H., Gong, Z., Hogendoorn, P.C., Spaink, H.P., and Snaar-Jagalska, B.E. (2011) A DeltaRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. The Journal of pathology. 225(1):19-28
Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
Taylor, K.L., Lister, J.A., Zeng, Z., Ishizaki, H., Anderson, C., Kelsh, R.N., Jackson, I.J., and Patton, E.E. (2011) Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf. Development (Cambridge, England). 138(16):3579-89
Thakur, P.C., Stuckenholz, C., Rivera, M.R., Davison, J.M., Yao, J.K., Amsterdam, A., Sadler, K.C., and Bahary, N. (2011) Lack of De novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish. Hepatology (Baltimore, Md.). 54(2):452-62
Li, Z.H., Alex, D., Siu, S.O., Chu, I.K., Renn, J., Winkler, C., Lou, S., Tsui, S.K., Zhao, H.Y., Yan, W.R., Mahady, G.B., Li, G.H., Kwan, Y.W., Wang, Y.T., and Lee, S.M. (2011) Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae. Molecular Biosystems. 7(7):2128-38
Huang, X., Nguyen, A.T., Li, Z., Emelyanov, A., Parinov, S., and Gong, Z. (2011) One step forward: The use of transgenic zebrafish tumor model in drug screens. Birth defects research. Part C, Embryo today : reviews. 93(2):173-181
Lam, S.H., Lee, S.G., Lin, C.Y., Thomsen, J.S., Fu, P.Y., Murthy, K.R., Li, H., Govindarajan, K.R., Nick, L.C., Bourque, G., Gong, Z., Lufkin, T., Liu, E.T., and Mathavan, S. (2011) Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Medical Genomics. 4(1):41
Shu, X., Zeng, Z., Gautier, P., Lennon, A., Gakovic, M., Cheetham, M.E., Patton, E.E., and Wright, A.F. (2011) Knock-down of the Zebrafish Orthologue of the Retinitis Pigmentosa 2 (RP2) Gene Results in Retinal Degeneration. Investigative ophthalmology & visual science. 52(6):2960-6
Sukardi, H., Chng, H.T., Chan, E.C., Gong, Z., and Lam, S.H. (2011) Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert opinion on drug metabolism & toxicology. 7(5):579-589
Paul, T.A., Rovnak, J., Quackenbush, S.L., Whitlock, K., Zhan, H., Gong, Z., Spitsbergen, J., Bowser, P.R., and Casey, J.W. (2011) Transgenic Expression of Walleye Dermal Sarcoma Virus rv-cyclin (orfA) in Zebrafish does not Result in Tissue Proliferation. Marine biotechnology (New York, N.Y.). 13(2):142-150
Yin, A., Korzh, S., Winata, C.L., Korzh, V., and Gong, Z. (2011) Wnt signaling is required for early development of zebrafish swimbladder. PLoS One. 6(3):e18431
Asharani, P.V., Lianwu, Y., Gong, Z., and Valiyaveettil, S. (2011) Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos. Nanotoxicology. 5:43-54
Xiang, W., Ke, Z., Zhang, Y., Cheng, G.H., Irwan, I.D., Sulochana, K.N., Potturi, P., Wang, Z., Yang, H., Wang, J., Zhuo, L., Kini, R.M., and Ge, R. (2011) Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumor growth in mice. Journal of Cellular and Molecular Medicine. 15(2):359-74
Mirbahai, L., Williams, T.D., Zhan, H., Gong, Z., and Chipman, J.K. (2011) Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. BMC Genomics. 12:3
Lam, S.H., Hlaing, M.M., Zhang, X., Yan, C., Duan, Z., Zhu, L., Ung, C.Y., Mathavan, S., Ong, C.N., and Gong, Z. (2011) Toxicogenomic and phenotypic analyses of bisphenol-a early-life exposure toxicity in zebrafish. PLoS One. 6(12):e28273
Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Ma, J., Zhang, L., Li, B., and Gong, Z. (2011) Existence of inverted profile in chemically responsive molecular pathways in the zebrafish liver. PLoS One. 6(11):e27819
Zheng, W., Wang, Z., Collins, J.E., Andrews, R.M., Stemple, D., and Gong, Z. (2011) Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung. PLoS One. 6(8):e24019
Wang, Z., Matsudaira, P., and Gong, Z. (2010) STORM: A General Model to Determine the Number and Adaptive Changes of Epithelial Stem Cells in Teleost, Murine and Human Intestinal Tracts. PLoS One. 5(11):e14063
Zhan, H., Spitsbergen, J.M., Qing, W., Wu, Y.L., Paul, T.A., Casey, J.W., Her, G.M., and Gong, Z. (2010) Transgenic Expression of Walleye Dermal Sarcoma Virus rv-cyclin Gene in Zebrafish and Its Suppressive Effect on Liver Tumor Development After Carcinogen Treatment. Marine biotechnology (New York, N.Y.). 12(6):640-649
Ishizaki, H., Spitzer, M., Wildenhain, J., Anastasaki, C., Zeng, Z., Dolma, S., Shaw, M., Madsen, E., Gitlin, J., Marais, R., Tyers, M., and Patton, E.E. (2010) Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation. Disease models & mechanisms. 3(9-10):639-651
Wang, Z., Du, J., Lam, S.H., Mathavan, S., Matsudaira, P., and Gong, Z. (2010) Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. BMC Genomics. 11:392
Mangos, S., Lam, P.Y., Zhao, A., Liu, Y., Mudumana, S., Vasilyev, A., Liu, A., and Drummond, I.A. (2010) The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Disease models & mechanisms. 3(5-6):354-365
Hong, N., Li, M., Zeng, Z., Yi, M., Deng, J., Gui, J., Winkler, C., Schartl, M., and Hong, Y. (2010) Accessibility of host cell lineages to medaka stem cells depends on genetic background and irradiation of recipient embryos. Cellular and molecular life sciences : CMLS. 67(7):1189-1202
Ung, C.Y., Lam, S.H., Hlaing, M.M., Winata, C.L., Korzh, S., Mathavan, S., and Gong, Z. (2010) Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics. 11:212
Sukardi, H., Ung, C.Y., Gong, Z., and Lam, S.H. (2010) Incorporating Zebrafish Omics into Chemical Biology and Toxicology. Zebrafish. 7(1):41-52
Shu, X., Zeng, Z., Gautier, P., Lennon, A., Gakovic, M., Patton, E., and Wright, A. (2010) Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes. Human molecular genetics. 19(4):657-670
Zhan, H., and Gong, Z. (2010) Delayed and Restricted Expression of UAS-Regulated GFP Gene in Early Transgenic Zebrafish Embryos by Using the GAL4/UAS System. Marine biotechnology (New York, N.Y.). 12(1):1-7
Winata, C.L., Korzh, S., Kondrychyn, I., Korzh, V., and Gong, Z. (2010) The role of vasculature and blood circulation in zebrafish swimbladder development. BMC Developmental Biology. 10:3
Ung, C.Y., Lam, S.H., and Gong, Z. (2009) Comparative Transcriptome Analyses Revealed Conserved Biological and Transcription Factor Target Modules Between the Zebrafish and Human Tumors. Zebrafish. 6(4):425-431
Zeng, Z., Richardson, J., Verduzco, D., Mitchell, D.L., and Patton, E.E. (2009) Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin. Zebrafish. 6(4):405-415
Li, Z., Korzh, V., and Gong, Z. (2009) DTA-mediated targeted ablation revealed differential interdependence of endocrine cell lineages in early development of zebrafish pancreas. Differentiation; research in biological diversity. 78(4):241-252
Winata, C.L., Korzh, S., Kondrychyn, I., Zheng, W., Korzh, V., and Gong, Z. (2009) Development of zebrafish swimbladder: the requirement of Hedgehog signaling in specification and organization of the three tissue layers. Developmental Biology. 331(2):222-236
Li, Z., Wen, C., Peng, J., Korzh, V., and Gong, Z. (2009) Generation of living color transgenic zebrafish to trace somatostatin-expressing cells and endocrine pancreas organization. Differentiation; research in biological diversity. 77(2):128-134
Vasilyev, A., Liu, Y., Mudumana, S., Mangos, S., Lam, P.Y., Majumdar, A., Zhao, J., Poon, K.L., Kondrychyn, I., Korzh, V., and Drummond, I.A. (2009) Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology. 7(1):e9
Lam, S.H., Krishna Murthy Karuturi, R., and Gong, Z. (2009) Zebrafish spotted-microarray for genome-wide expression profiling experiments: data acquisition and analysis. Methods in molecular biology (Clifton, N.J.). 546:197-226
Lam, S.H., Mathavan, S., and Gong, Z. (2009) Zebrafish spotted-microarray for genome-wide expression profiling experiments. Part I: array printing and hybridization. Methods in molecular biology (Clifton, N.J.). 546:175-195
Liu, X., Li, Z., Emelyanov, A., Parinov, S., and Gong, Z. (2008) Generation of oocyte-specifically expressed cre transgenic zebrafish for female germline excision of loxp-flanked transgene. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(10):2955-2962
Mudumana, S.P., Hentschel, D., Liu, Y., Vasilyev, A., and Drummond, I.A. (2008) odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development (Cambridge, England). 135(20):3355-3367
Korzh, S., Pan, X., Garcia-Lecea, M., Winata, C.L., Pan, X., Wohland, T., Korzh, V., and Gong, Z. (2008) Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Developmental Biology. 8(1):84
Pan, X., Zhan, H., and Gong, Z. (2008) Ornamental Expression of Red Fluorescent Protein in Transgenic Founders of White Skirt Tetra (Gymnocorymbus ternetzi). Marine biotechnology (New York, N.Y.). 10(5):497-501
Liu, L., Zhu, S., Gong, Z., and Low, B.C. (2008) K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis. PLoS One. 3(8):e2850
Lam, S.H., Mathavan, S., Tong, Y., Li, H., Karuturi, R.K., Wu, Y., Vega, V.B., Liu, E.T., and Gong, Z. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genetics. 4(7):e1000121
Asharani, P.V., Wu, Y.L., Gong, Z., and Valiyaveettil, S. (2008) Toxicity of silver nanoparticles in zebrafish models. Nanotechnology. 19(25):255102
Maeda, Y., Suzuki, T., Pan, X., Chen, G., Pan, S., Bartman, T., and Whitsett, J.A. (2008) Cul2 is required for the activity of hypoxia-inducible factor and vasculogenesis. The Journal of biological chemistry. 283(23):16084-16092
Farooq, M., Sulochana, K.N., Pan, X., To, J., Sheng, D., Gong, Z., and Ge, R. (2008) Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish. Developmental Biology. 317(1):336-353
Zhu, S., Korzh, V., Gong, Z., and Low, B.C. (2008) RhoA prevents apoptosis during zebrafish embryogenesis through activation of Mek/Erk pathway. Oncogene. 27(11):1580-1589
Cheng, P.Y., Lin, C.C., Wu, C.S., Lu, Y.F., Lin, C.Y., Chung, C.C., Chu, C.Y, Huang, C.J., Tsai, C.Y., Korzh, S., Wu, J.L., and Hwang, S.P. (2008) Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation. Development (Cambridge, England). 135(5):941-952
Ke, Z., Kondrichin, I., Gong, Z., and Korzh, V. (2008) Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Molecular and cellular neurosciences. 37(2):388-401
Wu, Y.L., Pan, X., Mudumana, S.P., Wang, H., Kee, P.W., and Gong, Z. (2008) Development of a heat shock inducible gfp transgenic zebrafish line by using the zebrafish hsp27 promoter. Gene. 408(1-2):85-94
Hegde, A., Qiu, N.C., Qiu, X., Ho, S.H., Tay, K.Q., George, J., Ng, F.S., Govindarajan, K.R., Gong, Z., Mathavan, S., and Jiang, Y.J. (2008) Genomewide Expression Analysis in Zebrafish mind bomb Alleles with Pancreas Defects of Different Severity Identifies Putative Notch Responsive Genes. PLoS One. 3(1):e1479
Li, Z., Korzh, V., and Gong, Z. (2007) Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development. BMC Developmental Biology. 7(1):117
Song, J., Kim, H.J., Gong, Z., Liu, N.A., and Lin, S. (2007) Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish. Developmental Biology. 303(2):561-575
Dong, P.D., Munson, C.A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J., and Stainier, D.Y. (2007) Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature Genetics. 39(3):397-402
Hinkes, B., Wiggins, R.C., Gbadegesin, R., Vlangos, C.N., Seelow, D., Nurnberg, G., Garg, P., Verma, R., Chaib, H., Hoskins, B.E., Ashraf, S., Becker, C., Hennies, H.C., Goyal, M., Wharram, B.L., Schachter, A.D., Mudumana, S., Drummond, I., Kerjaschki, D., Waldherr, R., Dietrich, A., Ozaltin, F., Bakkaloglu, A., Cleper, R., Basel-Vanagaite, L., Pohl, M., Griebel, M., Tsygin, A.N., Soylu, A., Muller, D., Sorli, C.S., Bunney, T.D., Katan, M., Liu, J., Attanasio, M., O'toole, J.F., Hasselbacher, K., Mucha, B., Otto, E.A., Airik, R., Kispert, A., Kelley, G.G., Smrcka, A.V., Gudermann, T., Holzman, L.B., Nurnberg, P., Hildebrandt, F. (2006) Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nature Genetics. 38(12):1397-1405
Lam, S.H., Winata, C.L., Tong, Y., Korzh, S., Lim, W.S., Korzh, V., Spitsbergen, J., Mathavan, S., Miller, L.D., Liu, E.T., and Gong, Z. (2006) Transcriptome Kinetics of Arsenic-induced Adaptive Response in Zebrafish Liver. Physiological Genomics. 27(3):351-361
Liu, X., Wang, H., and Gong, Z. (2006) Tandem-Repeated Zebrafish zp3 Genes Possess Oocyte-Specific Promoters and Are Insensitive to Estrogen Induction. Biology of reproduction. 74(6):1016-1025
Wan, H., Korzh, S., Li, Z., Mudumana, S.P., Korzh, V., Jiang, Y.J., Lin, S., and Gong, Z. (2006) Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Experimental cell research. 312(9):1526-1539
Tay, T.L., Lin, Q., Seow, T.K., Tan, K.H., Hew, C.L., and Gong, Z. (2006) Proteomic analysis of protein profiles during early development of the zebrafish, Danio rerio. Proteomics. 6(10):3176-3188
Lam, S.H., and Gong, Z. (2006) Modeling liver cancer using zebrafish: a comparative oncogenomics approach. Cell cycle (Georgetown, Tex.). 5(6):573-577
Zhu, S., Liu, L., Korzh, V., Gong, Z., and Low, B.C. (2006) RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho Kinase and Diaphanous: Use of zebrafish as an in vivo model for GTPase signaling. Cellular Signalling. 18(3):359-372
Lam, S.H., Wu, Y.L., Vega, V.B., Miller, L.D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K.R., Lee, S., Mathavan, S., Krishna Murthy, K.R., Buhler, D.R., Liu, E.T., and Gong, Z. (2006) Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat. Biotechnol.. 24(1):73-75
Mukhi, S., Pan, X., Cobb, G.P., and Patino, R. (2005) Toxicity of hexahydro-1,3,5-trinitro-1,3,5-triazine to larval zebrafish (Danio rerio). Chemosphere. 61(2):178-185
Zeng, Z., Liu, X., Seebah, S., and Gong, Z. (2005) Faithful expression of living color reporter genes in transgenic medaka under two tissue-specific zebrafish promoters. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(2):387-392
Wang, H., Tan, J.T., Emelyanov, A., Korzh, V., and Gong, Z. (2005) Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio. Gene. 356:91-100
Mathavan, S., Lee, S.G., Mak, A., Miller, L.D., Murthy, K.R., Govindarajan, K.R., Tong, Y., Wu, Y.L., Lam, S.H., Yang, H., Ruan, Y., Korzh, V., Gong, Z., Liu, E.T., and Lufkin, T. (2005) Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genetics. 1(2):e29
Lam, S.H., Sin, Y.M., Gong, Z., and Lam, T.J. (2005) Effects of thyroid hormone on the development of immune system in zebrafish. General and comparative endocrinology. 142(3):325-335
Pan, X., Wan, H., Chia, W., Tong, Y., and Gong, Z. (2005) Demonstration of site-directed recombination in transgenic zebrafish using the Cre/loxP system. Transgenic Research. 14(2):217-223
Ke, Z., Emelyanov, A., Lim, S.E., Korzh, V., and Gong, Z. (2005) Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 232(2):479-486
Wu, Y.L., and Gong, Z. (2004) A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. Gene. 338(1):75-83
Mudumana, S.P., Wan, H., Singh, M., Korzh, V., and Gong, Z. (2004) Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: Liver, intestine, and exocrine pancreas. Developmental Dynamics : an official publication of the American Association of Anatomists. 230(1):165-173
Tong, Y., Shan, T., Poh, Y.K., Yan, T., Wang, H., Lam, S.H., and Gong, Z. (2004) Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17beta-estradiol. Gene. 328:25-36
Lam, S.H., Chua, H.L., Gong, Z., Lam, T.J., and Sin, Y.M. (2004) Development and maturation of the immune system in zebrafish, Danio rerio: a gene expression profiling, in situ hybridization and immunological study. Developmental and comparative immunology. 28(1):9-28
Ko, C.S., Liu, H.S., Chen, W.H., Yan, T., and Lim, T.M. (2003) Effects of retinoid acid and thyroid hormone on the development of zebrafish embryo. Fertility and sterility. :269
Gong, Z., Wan, H., Tay, T.-L., Wang, H., Chen, M., and Yan, T. (2003) Development of transgenic fish for ornamental and bioreactor by strong expression of fluorescent proteins in the skeletal muscle. Biochemical and Biophysical Research Communications. 308(1):58-63
Wang, X., Emelyanov, A., Korzh, V., and Gong, Z. (2003) Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 227(4):587-592
Ju, B., Chong, S.-W., He, J., Wang, X, Xu, Y., Wan, H., Tong, Y., Yan, T., Korzh, V., and Gong, Z. (2003) Recapitulation of fast skeletal muscle development in zebrafish by transgenic expression of GFP under the mylz2 promoter. Developmental Dynamics : an official publication of the American Association of Anatomists. 227(1):14-26
Tan, C.-H., Chu, L.T., Weeraratne, S.D., Korzh, V., Lim, T.M., and Gong, Z. (2002) RETRACTED: Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults. Gene expression patterns : GEP. 2:257-260
Tan, C.H., Lee, T.C., Weeraratne, S.D., Korzh, V., Lim, T.M., and Gong, Z. (2002) Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults. Mechanisms of Development. (Suppl.) 119:S221-S224
Lam, S.H., Chua, H.L., Gong, Z., Wen, Z., Lam, T.J. and Sin, Y.M. (2002) Morphologic transformation of the thymus in developing zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 225(1):87-94
Zeng, S. and Gong, Z. (2002) Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Gene. 294(1-2):45-53
Wang, X., Korzh, V., and Gong, Z. (2002) The functional specificity of NeuroD is defined by a single amino acid residue (N11) in the basic domain. FEBS letters. 520(1-3):139-144
Gong, Z., Ju, B., Wang, X., He, J., Wan, H., Mudumana, S.P., and Yan, T. (2002) Green fluorescent protein expression in germ-line transmitted transgenic zebrafish under a stratified epithelial promoter from Keratin8. Developmental Dynamics : an official publication of the American Association of Anatomists. 223(2):204-215
Wan, H., He, J., Ju, B., Yan, T., Lam, T.J., and Gong, Z. (2002) Generation of Two-color Transgenic Zebrafish Using the Green and Red Fluorescent Protein Reporter Genes gfp and rfp. Marine biotechnology (New York, N.Y.). 4(2):146-54
Chong, S.-W., Emelyanov, A., Gong, Z., and Korzh, V. (2001) Expression pattern of two zebrafish genes, cxcr4a and cxcr4b. Mechanisms of Development. 109(2):347-354
Wang, X., Chu, L.T., He, J., Emelyanov, A., Korzh, V., and Gong, Z. (2001) A novel zebrafish bHLH gene, neurogenin3, is expressed in the hypothalamus. Gene. 275(1):47-55
Wang, X., Emelyanov, A., Sleptsova-Friedrich, I., Korzh, V., and Gong, Z. (2001) Expression of two novel zebrafish iroquois homologues (ziro1 and ziro5) during early development of axial structures and central nervous system. Mechanisms of Development. 105(1-2):191-195
Mudumana, S.P., Low, S., Kwang, J., and Gong, Z. (2001) Multiple Tissue Transformation in Adult Zebrafish by Gene Gun Bombardment and Muscular Injection of Naked DNA. Marine biotechnology (New York, N.Y.). 3(2):119-125
Gong, Z. (2001) Generation of rainbow color transgenic zebrafish. 6th Asian Fisheries Forum Book of Abstracts. :p. 85
Gong, Z., Ju, B., and Wan, H. (2001) Green fluorescent protein (GFP) transgenic fish and their applications. Genetica. 111(1-3):213-225
Wang, H., Yan, T., Tan, J.T., and Gong, Z. (2000) A zebrafish vitellogenin gene (vg3) encodes a novel vitellogenin without a phosvitin domain and may represent a primitive vertebrate vitellogenin gene. Gene. 256(1-2):303-310
Wang, X., Wan, H., Korzh, V., and Gong, Z. (2000) Use of an IRES bicistronic construct to trace expression of exogenously introduced mRNA in zebrafish embryos. Biotechniques. 29(4):814-8
Xu, Y.F., He, J.Y., Wang, X.K., Lim, T.M., and Gong, Z.Y. (2000) Asynchronous activation of 10 muscle-specific protein (MSP) genes during zebrafish somitogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 219(2):201-215
Loh, S.H., Chan, W.T., Gong, Z.Y., Lim, T.M., and Chua, K.L. (2000) Characterization of a zebrafish (Danio rerio) desmin cDNA: an early molecular marker of myogenesis. Differentiation; research in biological diversity. 65(5):247-254
Tan, J.T., Korzh, V., and Gong, Z.Y. (1999) Expression of a zebrafish iroquois homeobox gene, Ziro3, in the midline axial structures and central nervous system. Mechanisms of Development. 87(1-2):165-168
Garg, R.R., Bally-Cuif, L., Lee, S.E., Gong, Z., Ni, X., Hew, C.L., and Peng, C. (1999) Cloning of zebrafish activin type IIB receptor (ActRIIB) cDNA and mRNA expression of ActRIIB in embryos and adult tissues. Molecular and Cellular Endocrinology. 153(1-2):169-181
Wang, H. and Gong, Z.Y. (1999) Characterization of two zebrafish cDNA clones encoding egg envelope proteins ZP2 and ZP3. Biochim. Biophys. Acta Gene Struct. Exp.. 1446(1-2):156-160
Dheen, T., Sleptsova-Friedrich, I., Xu, Y., Clark, M., Lehrach, H., Gong, Z., and Korzh, V. (1999) Zebrafish tbx-c functions during formation of midline structures. Development (Cambridge, England). 126(12):2703-2713
Liao, J., He, J., Yan, T., Korzh, V., and Gong, Z. (1999) A class of neuroD-related basic helix-loop-helix transcription factors expressed in developing central nervous system in zebrafish. DNA and cell biology. 18(4):333-344
Gong, Z. (1999) Zebrafish expressed sequence tags and their applications. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:213-233
Ju, B., Xu, Y., He, J., Liao, J., Yan, T., Hew, C.L., Lam, T.J., and Gong, Z.Y. (1999) Faithful expression of green fluorescent protein (GFP) in transgenic zebrafish embryos under control of zebrafish gene promoters. Developmental genetics. 25(2):158-167
Xu, Y., He, J., Tian, H.L., Chan, C.H., Liao, J., Yan, T., Lam, T.J., and Gong, Z. (1999) Fast skeletal muscle-specific expression of a zebrafish myosin light chain 2 gene and characterization of its promotor by direct injection into skeletal muscle. DNA and cell biology. 18:85-95
Korzh, V., Sleptsova, I., Liao, J., He, J.Y., and Gong, Z. (1998) Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation. Developmental Dynamics : an official publication of the American Association of Anatomists. 213:92-104
Lim, J.H., He, J.Y., Korzh, V., and Gong, Z.Y. (1998) A new splicing variant of a type III POU gene from zebrafish encodes a POU protein with a distinct C-terminal. Biochim. Biophys. Acta Gene Struct. Exp.. 1397:253-256
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics. 18:345-349
Yan, T. and Gong, Z. (1998) Assembly of a complete zebrafish mitochondrial 16S rRNA gene from overlapping expressed sequence tags. DNA sequence : the journal of DNA sequencing and mapping. 9(3):145-148
Gong, Z.Y., Yan, T., Liao, J., Lee, S.E., He, J.Y., and Hew, C.L. (1997) Rapid identification and isolation of zebrafish cDNA clones. Gene. 201:87-98
Liao, J., Chan, C.H., and Gong, Z. (1997) An alternative linker-mediated polymerase chain reaction method using a dideoxynucleotide to reduce amplification background. Analytical biochemistry. 253:137-139
Liao, J., He, J., and Gong, Z. (1997) An abundant zebrafish cDNA clone encodes a ras-like protein which is expressed ubiquitously. DNA sequence : the journal of DNA sequencing and mapping. 7(5):313-317
Tokumoto, M., Gong, Z.Y., Tsubokawa, T., Hew, C.L., Uyemura, K., Hotta, Y., and Okamoto, H. (1995) Molecular heterogeneity among primary motoneurons and within myotomes revealed by the differential mRNA expression of novel islet-1 homologs in embryonic zebrafish. Developmental Biology. 171:578-589
Gong, Z., Hui, C.C., and Hew, C.L. (1995) Presence of isl-1-related LIM domain homeobox genes in teleost and their similar patterns of expression in brain and spinal cord. The Journal of biological chemistry. 270:3335-3345