ZFIN ID: ZDB-PERS-960805-206
Gong, Zhiyuan
Email: dbsgzy@nus.edu.sg
Affiliation: Zhiyuan Gong Lab
Address: Department of Biological Sciences The National University of Singapore 10 Kent Ridge Crescent Singapore, 119260 Singapore
Country: Singapore
Phone: 65-687-42860
Fax: 65-677-92486
Orcid ID:


Lu, J.W., Raghuram, D., Fong, P.A., Gong, Z. (2018) Inducible Intestine-Specific Expression of krasV12 Triggers Intestinal Tumorigenesis In Transgenic Zebrafish.. Neoplasia (New York, N.Y.). 20:1187-1197
Mishra, P., Gong, Z., Kelly, B.C. (2018) Assessing pH-dependent toxicity of fluoxetine in embryonic zebrafish using mass spectrometry-based metabolomics. Sci. Total Environ.. 650:2731-2741
Yao, Y., Sun, S., Wang, J., Fei, F., Dong, Z., Ke, A.W., He, R., Wang, L., Zhang, L., Ji, M.B., Li, Q., Yu, M., Shi, G.M., Fan, J., Gong, Z., Wang, X. (2018) Canonical Wnt signaling remodels lipid metabolism in zebrafish hepatocytes following Ras oncogenic insult. Cancer research. 78(19):5548-5560
Xu, H., Zhang, X., Li, H., Li, C., Huo, X.J., Hou, L.P., Gong, Z. (2018) Immune response induced by major environmental pollutants through altering neutrophils in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 201:99-108
Yang, Q., Yan, C., Gong, Z. (2018) Interaction of hepatic stellate cells with neutrophils and macrophages in the liver following oncogenic kras activation in transgenic zebrafish. Scientific Reports. 8:8495
Chen, H., Sheng, L., Gong, Z., Ru, S., Bian, H. (2018) Investigation of the molecular mechanisms of hepatic injury upon naphthalene exposure in zebrafish (Danio rerio). Ecotoxicology (London, England). 27(6):650-660
Yan, C., Yang, Q., Gong, Z. (2018) Activation of Hepatic Stellate Cells During Liver Carcinogenesis Requires Fibrinogen/Integrin αvβ5 in Zebrafish. Neoplasia (New York, N.Y.). 20:533-542
Leong, W.Z., Tan, S.H., Ngoc, P.C.T., Amanda, S., Yam, A.W.Y., Liau, W.S., Gong, Z., Lawton, L.N., Tenen, D.G., Sanda, T. (2018) ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis. Genes & Development. 31(23-24):2343-2360
Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44
Mishra, P., Gong, Z., Kelly, B.C. (2017) Assessing biological effects of fluoxetine in developing zebrafish embryos using gas chromatography-mass spectrometry based metabolomics. Chemosphere. 188:157-167
Xu, H., Li, C., Suklai, P., Zeng, Q., Chong, R., Gong, Z. (2017) Differential sensitivities to dioxin-like compounds PCB 126 and PeCDF between Tg(cyp1a:gfp) transgenic medaka and zebrafish larvae. Chemosphere. 192:24-30
Chen, F., Gong, Z., Kelly, B.C. (2017) Bioaccumulation behavior of pharmaceuticals and personal care products in adult zebrafish (Danio Rerio): influence of physical-chemical properties and biotransformation. Environ. Sci. Technol.. 51(19):11085-11095
Zhou, H., George, S., Li, C., Gurusamy, S., Sun, X., Gong, Z., Qian, H. (2017) Combined toxicity of prevalent mycotoxins studied in fish cell line and zebrafish larvae revealed that type of interactions is dose-dependent. Aquatic toxicology (Amsterdam, Netherlands). 193:60-71
Yang, Q., Yan, C., Gong, Z. (2017) Activation of liver stromal cells is associated with male-biased liver tumor initiation in xmrk and Myc transgenic zebrafish. Scientific Reports. 7:10315
Yan, C., Yang, Q., Shen, H.M., Spitsbergen, J.M., Gong, Z. (2017) Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish.. Oncotarget. 8:77096-77109
Liau, W.S., Tan, S.H., Ngoc, P.C., Wang, C.Q., Tergaonkar, V., Feng, H., Gong, Z., Osato, M., Look, A.T., Sanda, T. (2017) Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Leukemia. 31(8):1798-1807
Hou, H.A., Lu, J.W., Lin, T.Y., Tsai, C.H., Chou, W.C., Lin, C.C., Kuo, Y.Y., Liu, C.Y., Tseng, M.H., Chiang, Y.C., Peng, Y.L., Tang, J.L., Gong, Z., Lin, L.I., Tien, H.F. (2017) Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia. Blood cancer journal. 7:e588
Pant, S., Li, C., Gong, Z., Chen, N. (2017) Line-scan focal modulation microscopy. Journal of Biomedical Optics. 22:50502
Yan, C., Yang, Q., Huo, X., Li, H., Zhou, L., Gong, Z. (2017) Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish.. Scientific Reports. 7:45796
Chen, Q., Li, C., Gong, Z., Chan, E.C., Snyder, S.A., Lam, S.H. (2017) Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 172:429-439
Yan, C., Yang, Q., Gong, Z. (2017) Tumor-associated neutrophils and macrophages promote gender disparity in hepatocellular carcinoma in zebrafish. Cancer research. 77(6):1395-1407
Li, Y., Li, H., Spitsbergen, J.M., Gong, Z. (2017) Males develop faster and more severe hepatocellular carcinoma than females in krasV12 transgenic zebrafish.. Scientific Reports. 7:41280
Yang, Q., Yan, C., Yin, C., Gong, Z. (2017) Serotonin Activated Hepatic Stellate Cells Contribute to Sex Disparity in Hepatocellular Carcinoma. Cellular and molecular gastroenterology and hepatology. 3:484-499
Chen, F., Gong, Z., Kelly, B.C. (2016) Bioavailability and bioconcentration potential of perfluoroalkyl-phosphinic and -phosphonic acids in zebrafish (Danio rerio): Comparison to perfluorocarboxylates and perfluorosulfonates. Sci. Total Environ.. 568:33-41
Zhao, Y., Huang, X., Ding, T.W., Gong, Z. (2016) Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish. Scientific Reports. 6:31952
Lui, E.Y., Li, C., Li, Z.H., Gong, Z., Lam, S.H. (2016) Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. Journal of genetics and genomics = Yi chuan xue bao. 43(8):525-8
Li, C., Tan, X.F., Lim, T.K., Lin, Q., Gong, Z. (2016) Comprehensive and quantitative proteomic analyses of zebrafish plasma reveals conserved protein profiles between genders and between zebrafish and human. Scientific Reports. 6:24329
Li, C., Li, P., Tan, Y.M., Lam, S.H., Chan, E.C., Gong, Z. (2016) Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish. PLoS One. 11:e0151225
Chen, Q., Jia, A., Snyder, S.A., Gong, Z., Lam, S.H. (2016) Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 144:1162-1169
Nguyen, A.T., Koh, V., Spitsbergen, J.M., Gong, Z. (2016) Development of a conditional liver tumor model by mifepristone-inducible Cre recombination to control oncogenic kras(V12) expression in transgenic zebrafish. Scientific Reports. 6:19559
Liu, C., Su, G., Giesy, J.P., Letcher, R.J., Li, G., Agrawal, I., Li, J., Yu, L., Wang, J., Gong, Z. (2016) Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Scientific Reports. 6:19045
Huang, X., Agrawal, I., Li, Z., Zheng, W., Lin, Q., Gong, Z. (2016) Transcriptomic Analyses in Zebrafish Cancer Models for Global Gene Expression and Pathway Discovery. Advances in experimental medicine and biology. 916:147-68
Xu, H., Li, C., Li, Y., Ng, G.H., Liu, C., Zhang, X., Gong, Z. (2015) Generation of Tg(cyp1a:gfp) Transgenic Zebrafish for Development of a Convenient and Sensitive In Vivo Assay for Aryl Hydrocarbon Receptor Activity. Mar. Biotechnol.. 17(6):831-40
Yan, C., Huo, X., Wang, S., Feng, Y., Gong, Z. (2015) Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. Journal of hepatology. 63(2):420-8
Yan, C., Zheng, W., Gong, Z. (2015) Zebrafish fgf10b has a Complementary Function to fgf10a in Liver and Pancreas Development. Mar. Biotechnol.. 17(2):162-7
Chen, F., Gong, Z., Kelly, B.C. (2015) Rapid analysis of pharmaceuticals and personal care products in fish plasma micro-aliquots using liquid chromatography tandem mass spectrometry. Journal of chromatography. A. 1383:104-11
Sun, L., Nguyen, A.T., Spitsbergen, J.M., Gong, Z. (2015) Myc-Induced Liver Tumors in Transgenic Zebrafish Can Regress in tp53 Null Mutation. PLoS One. 10:e0117249
Wang, J., Lee, Y.M., Li, C., Li, P., Li, Z., Lim, T.K., Gong, Z., Lin, Q. (2015) Dramatic improvement of proteomic analysis of zebrafish liver tumor by effective protein extraction with sodium deoxycholate and heat denaturation. International journal of analytical chemistry. 2015:763969
Chew, T.W., Liu, X.J., Liu, L., Spitsbergen, J.M., Gong, Z., and Low, B.C. (2014) Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models. Oncogene. 33(21):2717-27
Han, Z., Wang, Q., Fu, J., Chen, H., Zhao, Y., Zhou, B., Gong, Z., Wei, S., Li, J., Liu, H., Zhang, X., Liu, C., Yu, H. (2014) Multiple bio-analytical methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate. Aquatic toxicology (Amsterdam, Netherlands). 150:175-81
Zheng, W., Li, Z., Nguyen, A.T., Li, C., Emelyanov, A., Gong, Z. (2014) Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. PLoS One. 9:e91179
Zhang, X., Li, C., Gong, Z. (2014) Development of a convenient in vivo hepatotoxin assay using a transgenic zebrafish line with liver-specific DsRed expression. PLoS One. 9:e91874
Liu, C., Xu, H., Lam, S.H., and Gong, Z. (2013) Selection of Reliable Biomarkers from PCR Array Analyses Using Relative Distance Computational Model: Methodology and Proof-of-Concept Study. PLoS One. 8(12):e83954
Li, Z.H., Xu, H., Zheng, W., Lam, S.H., and Gong, Z. (2013) RNA-Sequencing Analysis of TCDD-Induced Responses in Zebrafish Liver Reveals High Relatedness to In Vivo Mammalian Models and Conserved Biological Pathways. PLoS One. 8(10):e77292
Lam, S.H., Ung, C.Y., Hlaing, M.M., Hu, J., Li, Z.H., Mathavan, S., and Gong, Z. (2013) Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: Transcriptomic, histological and targeted gene expression analyses. BBA General Subjects. 1830(10):4778-4789
Fu, J., Han, J., Zhou, B., Gong, Z., Santos, E.M., Huo, X., Zheng, W., Liu, H., Yu, H., and Liu, C. (2013) Toxicogenomic Responses of Zebrafish Embryos/Larvae to Tris(1,3-dichloro-2-propyl) Phosphate (TDCPP) Reveal Possible Molecular Mechanisms of Developmental Toxicity. Environ. Sci. Technol.. 47(18):10574-82
Xu, H., Lam, S.H., Shen, Y., and Gong, Z. (2013) Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PLoS One. 8(7):e68737
Gabor, K.A., Stevens, C.R., Pietraszewski, M.J., Gould, T.J., Shim, J., Yoder, J.A., Lam, S.H., Gong, Z., Hess, S.T., and Kim, C.H. (2013) Super Resolution Microscopy Reveals that Caveolin-1 Is Required for Spatial Organization of CRFB1 and Subsequent Antiviral Signaling in Zebrafish. PLoS One. 8(7):e68759
Huang, S.M., Xu, F., Lam, S.H., Gong, Z., and Ong, C.N. (2013) Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry. Molecular Biosystems. 9(6):1372-80
Li, Z., Zheng, W., Wang, Z., Zeng, Z., Zhan, H., Li, C., Zhou, L., Yan, C., Spitsbergen, J.M., and Gong, Z. (2013) A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors. Disease models & mechanisms. 427(1):223-226
Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Zhang, L., Li, B., and Gong, Z. (2013) Inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases. PLoS One. 8(2):e56668
Zhang, X., and Gong, Z. (2013) Fluorescent Transgenic Zebrafish Tg(nkx2.2a:mEGFP) Provides a Highly Sensitive Monitoring Tool for Neurotoxins. PLoS One. 8(2):e55474
Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
Cui, J., Sim, T.H., Gong, Z., and Shen, H.M. (2012) Generation of transgenic zebrafish with liver-specific expression of EGFP-Lc3: A new in vivo model for investigation of liver autophagy. Biochemical and Biophysical Research Communications. 422(2):268-273
Pavagadhi, S., Gong, Z., Hande, M.P., Dionysioum, D.D., de la Cruz, A.A., and Balasubramanian, R. (2012) Biochemical response of diverse organs in adult Danio rerio (zebrafish) exposed to sub-lethal concentrations of microcystin-LR and microcystin-RR: A balneation study. Aquatic toxicology (Amsterdam, Netherlands). 109C:1-10
Li, Z., Huang, X., Zhan, H., Zeng, Z., Li, C., Spitsbergen, J.M., Meierjohann, S., Schartl, M., and Gong, Z. (2012) Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish. Journal of hepatology. 56(2):419-425
Yin, A., Korzh, V., and Gong, Z. (2012) Perturbation of zebrafish swimbladder development by enhancing Wnt signaling in Wif1 morphants. BBA Molecular Cell Research. 1823(2):236-244
Sukardi, H., Zhang, X., Lui, E.Y., Ung, C.Y., Mathavan, S., Gong, Z., and Lam, S.H. (2012) Liver X receptor agonist T0901317 induced liver perturbation in zebrafish: Histological, gene set enrichment and expression analyses. BBA General Subjects. 1820(1):33-43
Nguyen, A.T., Emelyanov, A., Koh, C.H., Spitsbergen, J.M., Parinov, S., and Gong, Z. (2012) An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening. Disease models & mechanisms. 5(1):63-72
Huang, X., Zhou, L., and Gong, Z. (2012) Liver tumor models in transgenic zebrafish: an alternative in vivo approach to study hepatocarcinogenes. Future oncology (London, England). 8(1):21-28
Zhang, X., Ung, C.Y., Lam, S.H., Ma, J., Chen, Y.Z., Zhang, L., Gong, Z., and Li, B. (2012) Toxicogenomic analysis suggests chemical-induced sexual dimorphism in the expression of metabolic genes in zebrafish liver. PLoS One. 7(12):e51971
Korzh, S., Winata, C.L., Zheng, W., Yang, S., Yin, A., Ingham, P., Korzh, V., and Gong, Z. (2011) The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental Biology. 359(2):262-76
He, S., Krens, S.G., Zhan, H., Gong, Z., Hogendoorn, P.C., Spaink, H.P., and Snaar-Jagalska, B.E. (2011) A DeltaRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. The Journal of pathology. 225(1):19-28
Aanes, H., Winata, C.L., Lin, C.H., Chen, J.P., Srinivasan, K.G., Lee, S.G., Lim, A.Y., Hajan, H.S., Collas, P., Bourque, G., Gong, Z., Korzh, V., Aleström, P., and Mathavan, S. (2011) Zebrafish mRNA sequencing deciphers novelties in transcriptome dynamics during maternal to zygotic transition. Genome research. 21(8):1328-38
Huang, X., Nguyen, A.T., Li, Z., Emelyanov, A., Parinov, S., and Gong, Z. (2011) One step forward: The use of transgenic zebrafish tumor model in drug screens. Birth defects research. Part C, Embryo today : reviews. 93(2):173-181
Lam, S.H., Lee, S.G., Lin, C.Y., Thomsen, J.S., Fu, P.Y., Murthy, K.R., Li, H., Govindarajan, K.R., Nick, L.C., Bourque, G., Gong, Z., Lufkin, T., Liu, E.T., and Mathavan, S. (2011) Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Medical Genomics. 4(1):41
Sukardi, H., Chng, H.T., Chan, E.C., Gong, Z., and Lam, S.H. (2011) Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert opinion on drug metabolism and toxicology. 7(5):579-589
Paul, T.A., Rovnak, J., Quackenbush, S.L., Whitlock, K., Zhan, H., Gong, Z., Spitsbergen, J., Bowser, P.R., and Casey, J.W. (2011) Transgenic Expression of Walleye Dermal Sarcoma Virus rv-cyclin (orfA) in Zebrafish does not Result in Tissue Proliferation. Mar. Biotechnol.. 13(2):142-150
Yin, A., Korzh, S., Winata, C.L., Korzh, V., and Gong, Z. (2011) Wnt signaling is required for early development of zebrafish swimbladder. PLoS One. 6(3):e18431
Asharani, P.V., Lianwu, Y., Gong, Z., and Valiyaveettil, S. (2011) Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos. Nanotoxicology. 5:43-54
Mirbahai, L., Williams, T.D., Zhan, H., Gong, Z., and Chipman, J.K. (2011) Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis. BMC Genomics. 12:3
Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Ma, J., Zhang, L., Li, B., and Gong, Z. (2011) Existence of inverted profile in chemically responsive molecular pathways in the zebrafish liver. PLoS One. 6(11):e27819
Zheng, W., Wang, Z., Collins, J.E., Andrews, R.M., Stemple, D., and Gong, Z. (2011) Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and Mammalian lung. PLoS One. 6(8):e24019
Lam, S.H., Hlaing, M.M., Zhang, X., Yan, C., Duan, Z., Zhu, L., Ung, C.Y., Mathavan, S., Ong, C.N., and Gong, Z. (2011) Toxicogenomic and phenotypic analyses of bisphenol-a early-life exposure toxicity in zebrafish. PLoS One. 6(12):e28273
Wang, Z., Matsudaira, P., and Gong, Z. (2010) STORM: A General Model to Determine the Number and Adaptive Changes of Epithelial Stem Cells in Teleost, Murine and Human Intestinal Tracts. PLoS One. 5(11):e14063
Zhan, H., Spitsbergen, J.M., Qing, W., Wu, Y.L., Paul, T.A., Casey, J.W., Her, G.M., and Gong, Z. (2010) Transgenic Expression of Walleye Dermal Sarcoma Virus rv-cyclin Gene in Zebrafish and Its Suppressive Effect on Liver Tumor Development After Carcinogen Treatment. Mar. Biotechnol.. 12(6):640-649
Wang, Z., Du, J., Lam, S.H., Mathavan, S., Matsudaira, P., and Gong, Z. (2010) Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. BMC Genomics. 11:392
Ung, C.Y., Lam, S.H., Hlaing, M.M., Winata, C.L., Korzh, S., Mathavan, S., and Gong, Z. (2010) Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics. 11:212
Sukardi, H., Ung, C.Y., Gong, Z., and Lam, S.H. (2010) Incorporating Zebrafish Omics into Chemical Biology and Toxicology. Zebrafish. 7(1):41-52
Zhan, H., and Gong, Z. (2010) Delayed and Restricted Expression of UAS-Regulated GFP Gene in Early Transgenic Zebrafish Embryos by Using the GAL4/UAS System. Mar. Biotechnol.. 12(1):1-7
Winata, C.L., Korzh, S., Kondrychyn, I., Korzh, V., and Gong, Z. (2010) The role of vasculature and blood circulation in zebrafish swimbladder development. BMC Developmental Biology. 10:3
Ung, C.Y., Lam, S.H., and Gong, Z. (2009) Comparative Transcriptome Analyses Revealed Conserved Biological and Transcription Factor Target Modules Between the Zebrafish and Human Tumors. Zebrafish. 6(4):425-431
Li, Z., Korzh, V., and Gong, Z. (2009) DTA-mediated targeted ablation revealed differential interdependence of endocrine cell lineages in early development of zebrafish pancreas. Differentiation; research in biological diversity. 78(4):241-252
Winata, C.L., Korzh, S., Kondrychyn, I., Zheng, W., Korzh, V., and Gong, Z. (2009) Development of zebrafish swimbladder: the requirement of Hedgehog signaling in specification and organization of the three tissue layers. Developmental Biology. 331(2):222-236
Li, Z., Wen, C., Peng, J., Korzh, V., and Gong, Z. (2009) Generation of living color transgenic zebrafish to trace somatostatin-expressing cells and endocrine pancreas organization. Differentiation; research in biological diversity. 77(2):128-134
Lam, S.H., Krishna Murthy Karuturi, R., and Gong, Z. (2009) Zebrafish spotted-microarray for genome-wide expression profiling experiments: data acquisition and analysis. Meth. Mol. Biol.. 546:197-226
Lam, S.H., Mathavan, S., and Gong, Z. (2009) Zebrafish spotted-microarray for genome-wide expression profiling experiments. Part I: array printing and hybridization. Meth. Mol. Biol.. 546:175-195
Liu, X., Li, Z., Emelyanov, A., Parinov, S., and Gong, Z. (2008) Generation of oocyte-specifically expressed cre transgenic zebrafish for female germline excision of loxp-flanked transgene. Developmental dynamics : an official publication of the American Association of Anatomists. 237(10):2955-2962
Korzh, S., Pan, X., Garcia-Lecea, M., Winata, C.L., Pan, X., Wohland, T., Korzh, V., and Gong, Z. (2008) Requirement of vasculogenesis and blood circulation in late stages of liver growth in zebrafish. BMC Developmental Biology. 8(1):84
Pan, X., Zhan, H., and Gong, Z. (2008) Ornamental Expression of Red Fluorescent Protein in Transgenic Founders of White Skirt Tetra (Gymnocorymbus ternetzi). Mar. Biotechnol.. 10(5):497-501
Liu, L., Zhu, S., Gong, Z., and Low, B.C. (2008) K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis. PLoS One. 3(8):e2850
Lam, S.H., Mathavan, S., Tong, Y., Li, H., Karuturi, R.K., Wu, Y., Vega, V.B., Liu, E.T., and Gong, Z. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genetics. 4(7):e1000121
Asharani, P.V., Wu, Y.L., Gong, Z., and Valiyaveettil, S. (2008) Toxicity of silver nanoparticles in zebrafish models. Nanotechnology. 19(25):255102
Farooq, M., Sulochana, K.N., Pan, X., To, J., Sheng, D., Gong, Z., and Ge, R. (2008) Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish. Developmental Biology. 317(1):336-353
Zhu, S., Korzh, V., Gong, Z., and Low, B.C. (2008) RhoA prevents apoptosis during zebrafish embryogenesis through activation of Mek/Erk pathway. Oncogene. 27(11):1580-1589
Ke, Z., Kondrichin, I., Gong, Z., and Korzh, V. (2008) Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling during zebrafish neurodevelopment. Molecular and Cellular Neuroscience. 37(2):388-401
Wu, Y.L., Pan, X., Mudumana, S.P., Wang, H., Kee, P.W., and Gong, Z. (2008) Development of a heat shock inducible gfp transgenic zebrafish line by using the zebrafish hsp27 promoter. Gene. 408(1-2):85-94
Hegde, A., Qiu, N.C., Qiu, X., Ho, S.H., Tay, K.Q., George, J., Ng, F.S., Govindarajan, K.R., Gong, Z., Mathavan, S., and Jiang, Y.J. (2008) Genomewide Expression Analysis in Zebrafish mind bomb Alleles with Pancreas Defects of Different Severity Identifies Putative Notch Responsive Genes. PLoS One. 3(1):e1479
Li, Z., Korzh, V., and Gong, Z. (2007) Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development. BMC Developmental Biology. 7(1):117
Song, J., Kim, H.J., Gong, Z., Liu, N.A., and Lin, S. (2007) Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish. Developmental Biology. 303(2):561-575
Dong, P.D., Munson, C.A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J., and Stainier, D.Y. (2007) Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature Genetics. 39(3):397-402
Lam, S.H., Winata, C.L., Tong, Y., Korzh, S., Lim, W.S., Korzh, V., Spitsbergen, J., Mathavan, S., Miller, L.D., Liu, E.T., and Gong, Z. (2006) Transcriptome Kinetics of Arsenic-induced Adaptive Response in Zebrafish Liver. Physiological Genomics. 27(3):351-361
Liu, X., Wang, H., and Gong, Z. (2006) Tandem-Repeated Zebrafish zp3 Genes Possess Oocyte-Specific Promoters and Are Insensitive to Estrogen Induction. Biology of reproduction. 74(6):1016-1025
Wan, H., Korzh, S., Li, Z., Mudumana, S.P., Korzh, V., Jiang, Y.J., Lin, S., and Gong, Z. (2006) Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter. Experimental cell research. 312(9):1526-1539
Tay, T.L., Lin, Q., Seow, T.K., Tan, K.H., Hew, C.L., and Gong, Z. (2006) Proteomic analysis of protein profiles during early development of the zebrafish, Danio rerio. Proteomics. 6(10):3176-3188
Lam, S.H., and Gong, Z. (2006) Modeling liver cancer using zebrafish: a comparative oncogenomics approach. Cell cycle (Georgetown, Tex.). 5(6):573-577
Zhu, S., Liu, L., Korzh, V., Gong, Z., and Low, B.C. (2006) RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho Kinase and Diaphanous: Use of zebrafish as an in vivo model for GTPase signaling. Cellular Signalling. 18(3):359-372
Lam, S.H., Wu, Y.L., Vega, V.B., Miller, L.D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K.R., Lee, S., Mathavan, S., Krishna Murthy, K.R., Buhler, D.R., Liu, E.T., and Gong, Z. (2006) Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat. Biotechnol.. 24(1):73-75
Zeng, Z., Liu, X., Seebah, S., and Gong, Z. (2005) Faithful expression of living color reporter genes in transgenic medaka under two tissue-specific zebrafish promoters. Developmental dynamics : an official publication of the American Association of Anatomists. 234(2):387-392
Wang, H., Tan, J.T., Emelyanov, A., Korzh, V., and Gong, Z. (2005) Hepatic and extrahepatic expression of vitellogenin genes in the zebrafish, Danio rerio. Gene. 356:91-100
Lam, S.H., Sin, Y.M., Gong, Z., and Lam, T.J. (2005) Effects of thyroid hormone on the development of immune system in zebrafish. Gen. Comp. Endocrinol.. 142(3):325-335
Pan, X., Wan, H., Chia, W., Tong, Y., and Gong, Z. (2005) Demonstration of site-directed recombination in transgenic zebrafish using the Cre/loxP system. Transgenic Research. 14(2):217-223
Ke, Z., Emelyanov, A., Lim, S.E., Korzh, V., and Gong, Z. (2005) Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development. Developmental dynamics : an official publication of the American Association of Anatomists. 232(2):479-486
Wu, Y.L., and Gong, Z. (2004) A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. Gene. 338(1):75-83
Mudumana, S.P., Wan, H., Singh, M., Korzh, V., and Gong, Z. (2004) Expression analyses of zebrafish transferrin, ifabp, and elastaseB mRNAs as differentiation markers for the three major endodermal organs: Liver, intestine, and exocrine pancreas. Developmental dynamics : an official publication of the American Association of Anatomists. 230(1):165-173
Tong, Y., Shan, T., Poh, Y.K., Yan, T., Wang, H., Lam, S.H., and Gong, Z. (2004) Molecular cloning of zebrafish and medaka vitellogenin genes and comparison of their expression in response to 17beta-estradiol. Gene. 328:25-36
Lam, S.H., Chua, H.L., Gong, Z., Lam, T.J., and Sin, Y.M. (2004) Development and maturation of the immune system in zebrafish, Danio rerio: a gene expression profiling, in situ hybridization and immunological study. Developmental and comparative immunology. 28(1):9-28
Gong, Z., Wan, H., Tay, T.-L., Wang, H., Chen, M., and Yan, T. (2003) Development of transgenic fish for ornamental and bioreactor by strong expression of fluorescent proteins in the skeletal muscle. Biochemical and Biophysical Research Communications. 308(1):58-63
Wang, X., Emelyanov, A., Korzh, V., and Gong, Z. (2003) Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development. Developmental dynamics : an official publication of the American Association of Anatomists. 227(4):587-592
Ju, B., Chong, S.-W., He, J., Wang, X, Xu, Y., Wan, H., Tong, Y., Yan, T., Korzh, V., and Gong, Z. (2003) Recapitulation of fast skeletal muscle development in zebrafish by transgenic expression of GFP under the mylz2 promoter. Developmental dynamics : an official publication of the American Association of Anatomists. 227(1):14-26
Tan, C.H., Lee, T.C., Weeraratne, S.D., Korzh, V., Lim, T.M., and Gong, Z. (2002) Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults. Mechanisms of Development. (Suppl.) 119:S221-S224
Tan, C.-H., Chu, L.T., Weeraratne, S.D., Korzh, V., Lim, T.M., and Gong, Z. (2002) RETRACTED: Ziwi, the zebrafish homologue of the Drosophila piwi: co-localization with vasa at the embryonic genital ridge and gonad-specific expression in the adults. Gene Expression Patterns. 2:257-260
Lam, S.H., Chua, H.L., Gong, Z., Wen, Z., Lam, T.J. and Sin, Y.M. (2002) Morphologic transformation of the thymus in developing zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 225(1):87-94
Zeng, S. and Gong, Z. (2002) Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Gene. 294(1-2):45-53
Wang, X., Korzh, V., and Gong, Z. (2002) The functional specificity of NeuroD is defined by a single amino acid residue (N11) in the basic domain. FEBS letters. 520(1-3):139-144
Wan, H., He, J., Ju, B., Yan, T., Lam, T.J., and Gong, Z. (2002) Generation of Two-color Transgenic Zebrafish Using the Green and Red Fluorescent Protein Reporter Genes gfp and rfp. Mar. Biotechnol.. 4(2):146-54
Gong, Z., Ju, B., Wang, X., He, J., Wan, H., Mudumana, S.P., and Yan, T. (2002) Green fluorescent protein expression in germ-line transmitted transgenic zebrafish under a stratified epithelial promoter from Keratin8. Developmental dynamics : an official publication of the American Association of Anatomists. 223(2):204-215
Chong, S.-W., Emelyanov, A., Gong, Z., and Korzh, V. (2001) Expression pattern of two zebrafish genes, cxcr4a and cxcr4b. Mechanisms of Development. 109(2):347-354
Wang, X., Chu, L.T., He, J., Emelyanov, A., Korzh, V., and Gong, Z. (2001) A novel zebrafish bHLH gene, neurogenin3, is expressed in the hypothalamus. Gene. 275(1):47-55
Wang, X., Emelyanov, A., Sleptsova-Friedrich, I., Korzh, V., and Gong, Z. (2001) Expression of two novel zebrafish iroquois homologues (ziro1 and ziro5) during early development of axial structures and central nervous system. Mechanisms of Development. 105(1-2):191-195
Mudumana, S.P., Low, S., Kwang, J., and Gong, Z. (2001) Multiple Tissue Transformation in Adult Zebrafish by Gene Gun Bombardment and Muscular Injection of Naked DNA. Mar. Biotechnol.. 3(2):119-125
Gong, Z., Ju, B., and Wan, H. (2001) Green fluorescent protein (GFP) transgenic fish and their applications. Genetica. 111(1-3):213-225
Gong, Z. (2001) Generation of rainbow color transgenic zebrafish. 6th Asian Fisheries Forum Book of Abstracts. :p. 85
Wang, H., Yan, T., Tan, J.T., and Gong, Z. (2000) A zebrafish vitellogenin gene (vg3) encodes a novel vitellogenin without a phosvitin domain and may represent a primitive vertebrate vitellogenin gene. Gene. 256(1-2):303-310
Wang, X., Wan, H., Korzh, V., and Gong, Z. (2000) Use of an IRES bicistronic construct to trace expression of exogenously introduced mRNA in zebrafish embryos. Biotechniques. 29(4):814-8
Xu, Y.F., He, J.Y., Wang, X.K., Lim, T.M., and Gong, Z.Y. (2000) Asynchronous activation of 10 muscle-specific protein (MSP) genes during zebrafish somitogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 219(2):201-215
Loh, S.H., Chan, W.T., Gong, Z.Y., Lim, T.M., and Chua, K.L. (2000) Characterization of a zebrafish (Danio rerio) desmin cDNA: an early molecular marker of myogenesis. Differentiation; research in biological diversity. 65(5):247-254
Tan, J.T., Korzh, V., and Gong, Z.Y. (1999) Expression of a zebrafish iroquois homeobox gene, Ziro3, in the midline axial structures and central nervous system. Mechanisms of Development. 87(1-2):165-168
Garg, R.R., Bally-Cuif, L., Lee, S.E., Gong, Z., Ni, X., Hew, C.L., and Peng, C. (1999) Cloning of zebrafish activin type IIB receptor (ActRIIB) cDNA and mRNA expression of ActRIIB in embryos and adult tissues. Molecular and Cellular Endocrinology. 153(1-2):169-181
Wang, H. and Gong, Z.Y. (1999) Characterization of two zebrafish cDNA clones encoding egg envelope proteins ZP2 and ZP3. Biochim. Biophys. Acta Gene Struct. Exp.. 1446(1-2):156-160
Dheen, T., Sleptsova-Friedrich, I., Xu, Y., Clark, M., Lehrach, H., Gong, Z., and Korzh, V. (1999) Zebrafish tbx-c functions during formation of midline structures. Development (Cambridge, England). 126(12):2703-2713
Liao, J., He, J., Yan, T., Korzh, V., and Gong, Z. (1999) A class of neuroD-related basic helix-loop-helix transcription factors expressed in developing central nervous system in zebrafish. DNA and cell biology. 18(4):333-344
Xu, Y., He, J., Tian, H.L., Chan, C.H., Liao, J., Yan, T., Lam, T.J., and Gong, Z. (1999) Fast skeletal muscle-specific expression of a zebrafish myosin light chain 2 gene and characterization of its promotor by direct injection into skeletal muscle. DNA and cell biology. 18:85-95
Gong, Z. (1999) Zebrafish expressed sequence tags and their applications. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:213-233
Ju, B., Xu, Y., He, J., Liao, J., Yan, T., Hew, C.L., Lam, T.J., and Gong, Z.Y. (1999) Faithful expression of green fluorescent protein (GFP) in transgenic zebrafish embryos under control of zebrafish gene promoters. Developmental genetics. 25(2):158-167
Korzh, V., Sleptsova, I., Liao, J., He, J.Y., and Gong, Z. (1998) Expression of zebrafish bHLH genes ngn1 and nrd defines distinct stages of neural differentiation. Developmental dynamics : an official publication of the American Association of Anatomists. 213:92-104
Lim, J.H., He, J.Y., Korzh, V., and Gong, Z.Y. (1998) A new splicing variant of a type III POU gene from zebrafish encodes a POU protein with a distinct C-terminal. Biochim. Biophys. Acta Gene Struct. Exp.. 1397:253-256
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics. 18:345-349
Yan, T. and Gong, Z. (1998) Assembly of a complete zebrafish mitochondrial 16S rRNA gene from overlapping expressed sequence tags. DNA sequence : the journal of DNA sequencing and mapping. 9(3):145-148
Gong, Z.Y., Yan, T., Liao, J., Lee, S.E., He, J.Y., and Hew, C.L. (1997) Rapid identification and isolation of zebrafish cDNA clones. Gene. 201:87-98
Liao, J., Chan, C.H., and Gong, Z. (1997) An alternative linker-mediated polymerase chain reaction method using a dideoxynucleotide to reduce amplification background. Analytical biochemistry. 253:137-139
Liao, J., He, J., and Gong, Z. (1997) An abundant zebrafish cDNA clone encodes a ras-like protein which is expressed ubiquitously. DNA sequence : the journal of DNA sequencing and mapping. 7(5):313-317
Tokumoto, M., Gong, Z.Y., Tsubokawa, T., Hew, C.L., Uyemura, K., Hotta, Y., and Okamoto, H. (1995) Molecular heterogeneity among primary motoneurons and within myotomes revealed by the differential mRNA expression of novel islet-1 homologs in embryonic zebrafish. Developmental Biology. 171:578-589
Gong, Z., Hui, C.C., and Hew, C.L. (1995) Presence of isl-1-related LIM domain homeobox genes in teleost and their similar patterns of expression in brain and spinal cord. The Journal of biological chemistry. 270:3335-3345