ZFIN ID: ZDB-PUB-030715-1
Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development
Wang, X., Emelyanov, A., Korzh, V., and Gong, Z.
Date: 2003
Source: Developmental dynamics : an official publication of the American Association of Anatomists   227(4): 587-592 (Journal)
Registered Authors: Gong, Zhiyuan, Korzh, Vladimir, Wang, Xukun
Keywords: neuroM, MATH3, neuroD, basic helix-loop-helix (bHLH), acerebellar, no isthmus, spiel ohne grensen
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Central Nervous System/embryology*
  • Chromosome Mapping
  • DNA Primers
  • DNA, Complementary/genetics
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism*
  • Gene Expression Profiling*
  • Helix-Loop-Helix Motifs/genetics
  • In Situ Hybridization
  • Molecular Sequence Data
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism*
  • Sequence Analysis, DNA
  • Zebrafish/embryology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 12889068 Full text @ Dev. Dyn.
Basic helix-loop-helix (bHLH) transcriptional activators function in development of various cell lineages, including the central nervous system. One of the bHLH proteins, Math3/Xath3/NeuroM, was suggested to act as a late proneural gene in the mouse, Xenopus, and chick. Here, we isolated a zebrafish homologue, named zath3, and analyzed its expression pattern in zebrafish embryos. In the neural plate, zath3 is expressed first in the primordia of the tegmentum and trigeminal ganglia and three classes of primary neurons: sensory neurons, interneurons, and motor neurons. During later development, zath3 transcripts were localized along the boundaries of the optic tectum in the midbrain and rhombomeres of the hindbrain. Analyses of zath3 expression in three mid-hindbrain boundary mutants, acerebellar, no isthmus, and spiel-ohne-grensen, indicated that distribution of zath3 mRNAs in the midbrain and hindbrain was dramatically disturbed. In addition, these mutants also affect expression of zath3 in the neuroretina.