PUBLICATION
Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development
- Authors
- Wang, X., Emelyanov, A., Korzh, V., and Gong, Z.
- ID
- ZDB-PUB-030715-1
- Date
- 2003
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 227(4): 587-592 (Journal)
- Registered Authors
- Gong, Zhiyuan, Korzh, Vladimir, Wang, Xukun
- Keywords
- neuroM, MATH3, neuroD, basic helix-loop-helix (bHLH), acerebellar, no isthmus, spiel ohne grensen
- MeSH Terms
-
- Sequence Analysis, DNA
- Amino Acid Sequence
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/metabolism*
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism*
- Basic Helix-Loop-Helix Transcription Factors
- Central Nervous System/embryology*
- DNA Primers
- Chromosome Mapping
- In Situ Hybridization
- Molecular Sequence Data
- Animals
- Zebrafish/embryology*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Helix-Loop-Helix Motifs/genetics
- Gene Expression Profiling*
- DNA, Complementary/genetics
- PubMed
- 12889068 Full text @ Dev. Dyn.
Citation
Wang, X., Emelyanov, A., Korzh, V., and Gong, Z. (2003) Zebrafish atonal homologue zath3 is expressed during neurogenesis in embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 227(4):587-592.
Abstract
Basic helix-loop-helix (bHLH) transcriptional activators function in development of various cell lineages, including the central nervous system. One of the bHLH proteins, Math3/Xath3/NeuroM, was suggested to act as a late proneural gene in the mouse, Xenopus, and chick. Here, we isolated a zebrafish homologue, named zath3, and analyzed its expression pattern in zebrafish embryos. In the neural plate, zath3 is expressed first in the primordia of the tegmentum and trigeminal ganglia and three classes of primary neurons: sensory neurons, interneurons, and motor neurons. During later development, zath3 transcripts were localized along the boundaries of the optic tectum in the midbrain and rhombomeres of the hindbrain. Analyses of zath3 expression in three mid-hindbrain boundary mutants, acerebellar, no isthmus, and spiel-ohne-grensen, indicated that distribution of zath3 mRNAs in the midbrain and hindbrain was dramatically disturbed. In addition, these mutants also affect expression of zath3 in the neuroretina.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping