ZFIN ID: ZDB-PUB-141019-4
Zebrafish fgf10b has a Complementary Function to fgf10a in Liver and Pancreas Development
Yan, C., Zheng, W., Gong, Z.
Date: 2015
Source: Marine biotechnology (New York, N.Y.)   17(2): 162-7 (Journal)
Registered Authors: Gong, Zhiyuan
Keywords: none
MeSH Terms:
  • Animals
  • Evolution, Molecular*
  • Fibroblast Growth Factor 10/genetics
  • Fibroblast Growth Factor 10/metabolism*
  • Gene Duplication/genetics
  • Gene Expression Regulation, Developmental/genetics*
  • Gene Knockdown Techniques
  • Histological Techniques
  • Image Processing, Computer-Assisted
  • In Situ Hybridization
  • Larva/anatomy & histology
  • Liver/embryology
  • Liver/metabolism*
  • Microscopy, Fluorescence
  • Morpholinos
  • Pancreas/embryology
  • Pancreas/metabolism*
  • Protein Isoforms/genetics
  • Protein Isoforms/metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 25326376 Full text @ Mar. Biotechnol.
Fgf10 is a critical growth factor in mammals for development of endodermal organs such as the liver, pancreas, lung, and gut. Due to whole genome duplication, the zebrafish has two fgf10 orthologs, fgf10a and fgf10b. While fgf10a has a role in development of the esophagus and swimbladder, we found in the present study that fgf10b had a complementary expression pattern in the liver, pancreas, and gut. Morpholino knockdown of Fgf10b further confirmed its essential role in the normal development of liver and pancreas. Thus, our data provide another example of functional partition of two duplicated othologous genes during evolution.