ZFIN ID: ZDB-PUB-141204-4
Temperature-sensitive splicing of mitfa by an intron mutation in zebrafish
Zeng, Z., Johnson, S.L., Lister, J.A., Patton, E.E.
Temperature-sensitive (ts) mutations have provided fundamental insight into in our understanding of gene function in vivo. Although they are rare in higher organisms, temperature sensitive mutations in the pigmentation pathways include tyrosinase ts mutations found in oculocutaneous albinism (OMIM: 606952), in Siamese cats and the Himalayan mouse (Giebel et al., 1991), and in kit in zebrafish (Rawls and Johnson, 2001). Microphthalmia-associated transcription factor (Mitf) is the master melanocyte transcription factor that has critical functions in melanocyte development, melanocyte stem cell renewal and the tanning response, and is an important drug target(Hsiao and Fisher, 2014). This article is protected by copyright. All rights reserved.
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