ZFIN ID: ZDB-PUB-130322-15
Inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases
Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Zhang, L., Li, B., and Gong, Z.
Date: 2013
Source: PLoS One   8(2): e56668 (Journal)
Registered Authors: Gong, Zhiyuan, Lam, Siew Hong
Keywords: none
Microarrays: GEO:GSE41622, GEO:GSE41623
MeSH Terms:
  • Animals
  • Chromosomes, Human/drug effects
  • Chromosomes, Human/genetics
  • Disease/genetics*
  • Female
  • Gene Expression Profiling*
  • Genetic Predisposition to Disease/genetics
  • Humans
  • Male
  • Sex Characteristics*
  • Toxicogenetics*
  • Zebrafish/genetics*
  • Zebrafish/physiology*
PubMed: 23457601 Full text @ PLoS One

The influence of sex factor is widely recognized in various diseases, but its molecular basis, particularly how sex-biased genes, those with sexually dimorphic expression, behave in response to toxico-pathological changes is poorly understood. In this study, zebrafish toxicogenomic data and transcriptomic data from human pathological studies were analysed for the responses of male- and female-biased genes. Our analyses revealed obvious inverted expression profiles of sex-biased genes, where affected males tended to up-regulate genes of female-biased expression and down-regulate genes of male-biased expression, and vice versa in affected females, in a broad range of toxico-pathological conditions. Intriguingly, the extent of these inverted profiles correlated well to the susceptibility or severity of a given toxico-pathological state, suggesting that inverted expression profiles of sex-biased genes observed in this study can be used as important indicators to assess biological disorders.