Publication |
Data |
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Fish |
Anatomy
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Breuer et al., 2024
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Fig. 1
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chd7iaf17/iaf17
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Fig. 2
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chd7iaf17/iaf17
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- intercalarium decreased size, abnormal
- intercalarium decreased thickness, abnormal
- neural arch deformed, abnormal
- neural arch increased angle to centrum, abnormal
- parapophysis decreased size, abnormal
- parapophysis decreased thickness, abnormal
- precaudal vertebra bone mineralization decreased process quality, abnormal
- precaudal vertebra increased volume, abnormal
- supraneural decreased size, abnormal
- supraneural decreased thickness, abnormal
- tripus decreased size, abnormal
- tripus decreased thickness, abnormal
- vertebra increased mass density, abnormal
- vertebra increased volume, abnormal
- Weberian apparatus decreased size, abnormal
- Weberian apparatus decreased thickness, abnormal
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Fig. 3
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chd7iaf17/iaf17
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- head osteoblast activation quality, abnormal
- head osteoclast active, abnormal
- osteoblast Ab3-runx2 labeling decreased distribution, abnormal
- scale osteoblast activation quality, abnormal
- scale osteoclast active, abnormal
- whole organism ctsk expression increased amount, abnormal
- whole organism postna expression decreased amount, abnormal
- whole organism runx2a expression decreased amount, abnormal
- whole organism runx2b expression decreased amount, abnormal
- whole organism sp7 expression decreased amount, abnormal
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Fig. 4
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chd7iaf17/iaf17
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- basihyal cartilage col2a1a expression absent, abnormal
- basihyal cartilage sox9a expression absent, abnormal
- ceratobranchial cartilage col2a1a expression absent, abnormal
- ceratobranchial cartilage sox9a expression absent, abnormal
- ceratobranchial cartilage ab1-col2a labeling decreased distribution, abnormal
- ceratobranchial cartilage ab4-h3 labeling increased distribution, abnormal
- ceratobranchial cartilage cell population proliferation increased process quality, abnormal
- ceratohyal cartilage col2a1a expression decreased distribution, abnormal
- ceratohyal cartilage sox9a expression decreased distribution, abnormal
- ceratohyal cartilage ab1-col2a labeling decreased distribution, abnormal
- ceratohyal cartilage ab4-h3 labeling increased distribution, abnormal
- ceratohyal cartilage cell population proliferation increased process quality, abnormal
- Meckel's cartilage col2a1a expression decreased distribution, abnormal
- Meckel's cartilage sox9a expression decreased distribution, abnormal
- Meckel's cartilage ab1-col2a labeling decreased distribution, abnormal
- Meckel's cartilage ab4-h3 labeling increased distribution, abnormal
- Meckel's cartilage cell population proliferation increased process quality, abnormal
- palatoquadrate cartilage ab1-col2a labeling decreased distribution, abnormal
- precaudal vertebra chondrocyte decreased amount, abnormal
- Weberian apparatus chondrocyte decreased amount, abnormal
- whole organism col2a1a expression decreased amount, abnormal
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Fig. 5
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chd7iaf17/iaf17
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Hodorovich et al., 2023
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Fig. 1
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chd7ncu101/+ (TL)
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chd7ncu101/ncu101 (TL)
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Fig. Table 1
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chd7rdu1002/rdu1002 (AB)
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chd7rdu1002/+ (AB)
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Fig. Table 2
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TL + CRISPR14-chd7
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MacLean et al., 2023
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Figure 1
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chd7hsi3/hsi3 (TU)
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Shi et al., 2023
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Figure 3
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chd7ah517/ah517 (AB)
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Figure 4
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chd7ah517/ah517; vu12Tg (AB)
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Figure 5
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chd7ah517/ah517; ue2Tg (AB)
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chd7ah517/ah517 (AB)
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Figure 6
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chd7ah517/ah517 (AB)
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Figure 7
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chd7ah517/ah517 (AB)
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Krueger et al., 2022
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Fig. 1
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chd7sa19732/sa19732
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Fig. 3
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chd7sa19732/+
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chd7sa19732/sa19732
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chd7sa19732/sa19732
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chd7sa19732/sa19732
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chd7hsi3/hsi3
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Fig. 4
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chd7sa19732/+
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chd7hsi3/+
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chd7sa19732/sa19732
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chd7hsi3/hsi3
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Fig. 5
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chd7hsi3/+
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chd7hsi3/hsi3
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Fig. 6
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chd7hsi3/+
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chd7hsi3/hsi3
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Sun et al., 2022
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FIGURE 2
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chd7sr6/sr6
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chd7sr5/+
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chd7sr6/+
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chd7sr5/sr5
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chd7sr5/sr5
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FIGURE 3
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chd7sr5/sr5
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chd7sr5/sr5
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- basihyal cartilage decreased width, abnormal
- basihyal cartilage morphology, abnormal
- ceratobranchial 1 cartilage decreased length, abnormal
- ceratobranchial 2 cartilage decreased length, abnormal
- ceratobranchial 3 cartilage decreased length, abnormal
- ceratobranchial 4 cartilage decreased length, abnormal
- ceratobranchial 4 cartilage shape, abnormal
- ceratobranchial 5 cartilage decreased length, abnormal
- ceratobranchial 5 tooth decreased amount, abnormal
- ceratobranchial cartilage chondrocyte disorganized, abnormal
- pharyngeal arch cartilage lacks parts or has fewer parts of type ceratobranchial 4 cartilage, abnormal
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FIGURE 4
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chd7sr5/sr5; hu7185Tg
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chd7sr5/sr5; hu7185Tg
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chd7sr5/+; hu7185Tg
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FIGURE 5
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chd7sr5/sr5; el818Tg; hu7185Tg; ncv22Tg; zf384Tg
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chd7sr5/+; el818Tg; hu7185Tg; ncv22Tg; zf384Tg
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Asad et al., 2019
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Fig. 1
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TU + MO3-chd7 + MO8-chd7
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zf148Tg + MO3-chd7 + MO8-chd7
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Fig. 5
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TU + MO3-chd7 + MO8-chd7
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Liu et al., 2019
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Fig. 1
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chd7ck004a/+
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Fig. 2
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chd7ck004a/+
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Fig. 3
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chd7ck004a/+
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Liu et al., 2019
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Fig. 5
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chd7ck004a/ck004a
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Cloney et al., 2018
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Fig. 1
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chd7hsi3/hsi3
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chd7hsi3/+
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Fig. 2
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TU + MO5-chd7
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Fig. 4
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chd7hsi3/hsi3
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chd7hsi3/+
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TU + MO5-chd7
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Fig. 5
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TU + MO5-chd7
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Fig. 6
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TU + MO5-chd7
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Fig. 7
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chd7hsi3/hsi3
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chd7hsi3/+
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Liu et al., 2018
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Fig. 1
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zdf8Tg + MO2-chd7
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AB + MO2-chd7
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Fig. 2
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AB + MO2-chd7
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hkz04tTg; nz50Tg + MO2-chd7
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nz50Tg + MO2-chd7
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- caudal hematopoietic tissue myb expression increased amount, abnormal
- caudal hematopoietic tissue hematopoietic stem cell ikzf1 expression increased amount, abnormal
- caudal hematopoietic tissue hematopoietic stem cell myb expression increased amount, abnormal
- caudal hematopoietic tissue hematopoietic stem cell increased amount, abnormal
- caudal hematopoietic tissue lymphoid progenitor cell EGFP expression increased amount, abnormal
- caudal hematopoietic tissue lymphoid progenitor cell increased amount, abnormal
- caudal hematopoietic tissue macrophage mfap4.1 expression increased amount, abnormal
- caudal hematopoietic tissue macrophage EGFP expression increased amount, abnormal
- caudal hematopoietic tissue macrophage increased amount, abnormal
- caudal hematopoietic tissue myeloid lineage restricted progenitor cell increased amount, abnormal
- caudal hematopoietic tissue neutrophil mpx expression increased amount, abnormal
- caudal hematopoietic tissue neutrophil DsRed2 expression increased amount, abnormal
- caudal hematopoietic tissue neutrophil increased amount, abnormal
- caudal hematopoietic tissue pro-T cell irf4a expression increased amount, abnormal
- caudal hematopoietic tissue pro-T cell increased amount, abnormal
- thymus myb expression decreased amount, abnormal
- thymus primordium lymphoid progenitor cell decreased amount, abnormal
- thymus T cell decreased amount, abnormal
- ventral wall of dorsal aorta hematopoietic stem cell ikzf1 expression increased amount, abnormal
- ventral wall of dorsal aorta hematopoietic stem cell myb expression increased amount, abnormal
- whole organism ikzf1 expression increased amount, abnormal
- whole organism mfap4.1 expression increased amount, abnormal
- whole organism mpx expression increased amount, abnormal
- whole organism myb expression increased amount, abnormal
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Fig. 3
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AB + MO2-chd7
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Fig. 4
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AB + MO2-chd7
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Fig. 5
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AB + MO2-chd7
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hkz04tTg; nz50Tg + MO2-chd7
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Fig. 6
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AB + MO2-chd7
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hkz04tTg + MO2-chd7
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Fig. 7
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zdf8Tg + MO2-chd7
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AB + MO2-chd7
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Fig. 8
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AB + MO2-chd7
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Fig. 9
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chd7ck004a/ck004a
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- pharyngeal arch 2 hand2 expression decreased amount, abnormal
- pharyngeal arch 3 hand2 expression decreased amount, abnormal
- pharyngeal arch 4 hand2 expression decreased amount, abnormal
- pharyngeal arch 5 hand2 expression decreased amount, abnormal
- pharyngeal pouch 1 nkx2.3 expression decreased amount, abnormal
- pharyngeal pouch 2 nkx2.3 expression decreased amount, abnormal
- pharyngeal pouch 3 nkx2.3 expression decreased amount, abnormal
- pharyngeal pouch 4 nkx2.3 expression decreased amount, abnormal
- pharyngeal pouch 5 nkx2.3 expression decreased amount, abnormal
- thymus foxn1 expression decreased amount, abnormal
- thymus ikzf1 expression decreased amount, abnormal
- thymus il7r expression decreased amount, abnormal
- thymus development disrupted, abnormal
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Fig. S10
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chd7ck004a/ck004a
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Fig. S2
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AB + MO2-chd7
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Fig. S3
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hkz04tTg + MO2-chd7
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Fig. S9
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AB + MO1-chd7
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Prykhozhij et al., 2017
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Fig. 4
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chd7hsi3/hsi3
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Asad et al., 2016
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Fig. 2
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TU + MO8-chd7
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Fig. 3
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ba2Tg + MO8-chd7
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TU + MO8-chd7
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Fig. 4
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w47Tg + MO8-chd7
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TU + MO8-chd7
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- eye iridophore absent, abnormal
- head melanoblast GFP expression increased amount, abnormal
- melanocyte dct expression decreased amount, abnormal
- melanocyte tyr expression decreased amount, abnormal
- neural crest melanoblast mitfa expression increased amount, abnormal
- neural crest melanoblast GFP expression increased amount, abnormal
- trunk iridophore absent, abnormal
- whole organism decreased pigmentation, abnormal
- whole organism Melanin decreased amount, abnormal
- whole organism melanocyte shape, abnormal
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Fig. 5
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zf148Tg + MO8-chd7
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TU + MO8-chd7
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Fig. 6
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zf15Tg + MO8-chd7
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TU + MO8-chd7
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Fig. 7
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ba2Tg + MO8-chd7
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TU + MO8-chd7
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- ceratobranchial cartilage absent, abnormal
- ceratohyal cartilage absent, abnormal
- head decreased size, abnormal
- Meckel's cartilage absent, abnormal
- pericardium edematous, abnormal
- perichondrium sox9b expression decreased amount, abnormal
- perichondrium disorganized, abnormal
- pharyngeal arch chondrocyte sox9a expression absent, abnormal
- pharyngeal arch neural crest cell dlx2a expression decreased amount, abnormal
- ventral mandibular arch absent, abnormal
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Fig. S4
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w47Tg + MO8-chd7
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Fig. S5
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TU + MO3-chd7
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zf148Tg + MO8-chd7
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ba2Tg + MO8-chd7
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TU + MO8-chd7
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Fig. S6
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TU + MO3-chd7
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TU + MO8-chd7
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Fig. S7
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ba2Tg + MO3-chd7
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Balasubramanian et al., 2014
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Fig. 2
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WT + MO2-chd7
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Balow et al., 2013
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Fig. 2
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TU + MO3-chd7
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Fig. 3
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TU + MO3-chd7
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Fig. 4
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TU + MO3-chd7
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Fig. S1
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TU + MO3-chd7
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Patten et al., 2012
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Fig. 2
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AB + MO1-chd7
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AB + MO2-chd7
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Fig. 3
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AB + MO1-chd7
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Fig. 4
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AB + MO1-chd7
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Fig. 5
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AB + MO1-chd7
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Fig. 6
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y1Tg + MO1-chd7
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AB + MO1-chd7
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Fig. 7
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AB + MO1-chd7
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Fig. 8
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AB + MO1-chd7
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Fig. 9
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y1Tg + MO1-chd7
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Fig. S2
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AB + MO1-chd7
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text only
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AB + MO1-chd7
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Jacobs-McDaniels et al., 2011
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Fig. 3
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AB + MO1-chd7
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AB + MO2-chd7
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Fig. 4
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AB + MO1-chd7
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Fig. S2
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AB + MO1-chd7
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