FIGURE

Fig. 8

ID

ZDB-FIG-120306-23

Publication

Patten et al., 2012 - Role of Chd7 in Zebrafish: A Model for CHARGE Syndrome

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Fig. 8

Chd7 is important for cranial ganglia development and proper projection of facial nerves.

Dorsal view (rostal towards the top) of confocal fluorescent composite images of hindbrain branchiomotor neurons in control-MO injected (A) and chd7-MO-injected (B) 48 hpf Isl1-GFP transgenic embryos. (C, D) Confocal fluorescent composite images showing anti-3A10 antibody-stained axons of 48 hpf embryos. The broken lines indicate the area of significant loss of VII nerves in chd7 morphants. nV, trigeminal motoneurons; Va, anterior trigeminal motoneurons; Vp, posterior trigeminal motoneurons; nVII, facial motoneurons; nX, Vagal motoneurons; V, trigeminal nerve; VII, facial nerve. Scale bar: 50 μm.

Expression Data

Gene:	GFP
Antibody:	Ab-3A10
Fish:	AB AB + MO1-chd7 rw012Tg (WIK) rw012Tg + MO1-chd7 (WIK)
Knockdown Reagent:	MO1-chd7
Anatomical Terms:	facial nerve motor nucleus facial nerve motor nucleus axon trigeminal motor nucleus trigeminal motor nucleus axon vagal lobe
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-chd7
Knockdown Reagent:	MO1-chd7
Observed In:	axonogenesis cranial nerve motor neuron facial ganglion facial ganglion axon facial nerve motor nucleus motor neuron trigeminal ganglion axon
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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