FIGURE

Fig. 4.

ID

ZDB-FIG-260408-113

Publication

Hancock et al., 2026 - Multi-omic analyses identify molecular targets of Chd7 that contribute to CHARGE syndrome model phenotypes

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Fig. 4.

At 5 dpf, downregulated transcripts with protein counterparts and inhibition of pathways emerge. (A) Volcano plot of DEGs comparing 5 dpf MUT to 5 dpf WT samples. (B) Volcano plot of DEPs comparing 5 dpf MUT compared to 5 dpf WT samples. (C) IPA pathway enrichment by patterns of DEGs from 5 dpf MUT compared to WT samples. (D) IPA pathway enrichment by patterns of DEPs from 5 dpf MUT compared to WT samples. (E) Overlap of DEGs with P<0.05 (Wald test) from 5 dpf HT and MUT versus WT samples (purple), and DEPs with P<0.05 (one-way ANOVA) from 5 dpf HT and MUT versus WT samples (green). (F) Overlap of 5 dpf DEGs and DEPs from E and Neuro-GO list. (G) Log₂ FC for selected DEGs and DEPs from overlap in E and F (underlined). *P<0.05, **P<0.01, ***P<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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