FIGURE

Figure 6

ID

ZDB-FIG-230916-137

Publication

Shi et al., 2023 - Deletion of the chd7 Hinders Oligodendrocyte Progenitor Cell Development and Myelination in Zebrafish

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Figure 6

Deficiency of chd7 lowered the quality of myelin sheath. (a) Transmission electron micrograph of the axons of Mauthner cells in the WT and KO groups of 5 dpf zebrafish larvae. Scale bars: 500 nm. (b) Transmission electron micrograph of other ventral axons in the WT and KO groups of 5 dpf zebrafish larvae, with yellow arrows indicating myelinated axons and red arrows indicating unmyelinated axons. Scale bars: 2 μm. (c,d) Myelin thickness analysis of Mauthner cells and other ventral axons. Compared with the WT group, both Mauthner cells and other ventral axons in the KO group had a higher ratio, implying thinner myelin sheaths. Data shown as mean ± sem. unpaired Student’s two-tailed t-test, * p < 0.05, **** p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chd7^ah517/ah517 (AB)
Observed In:	Mauthner neuron myelin sheath neuron myelin sheath
Stage:	Day 5

Phenotype Detail

Acknowledgments

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