FIGURE

Fig. 1.

ID

ZDB-FIG-260408-110

Publication

Hancock et al., 2026 - Multi-omic analyses identify molecular targets of Chd7 that contribute to CHARGE syndrome model phenotypes

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Fig. 1.

Loss of chd7 causes dysregulation of genes associated with neurodevelopmental and transcriptional regulation functions. (A,B) Principal component (PC) analysis of quantified RNAs for each sample and replicate (A), and quantified proteins for each sample and replicate (B). (C,D) Heatmaps of Log₂ expression averaged across biological replicates with hierarchical clustering by similar expression patterns of differentially expressed genes (DEGs) with P<0.05 (Wald test) and absolute value of fold change (FC)>1 in heterozygous (HT) or homozygous mutant (MUT) versus wild-type (WT) comparisons (n=1780) (C), and differentially expressed proteins (DEPs) with P<0.05 (one-way ANOVA) (D) in HT or MUT versus WT comparisons (n=553).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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