ZFIN Image: Hancock et al., 2026, Fig. 4.

Image

Figure Caption

Fig. 4.

At 5 dpf, downregulated transcripts with protein counterparts and inhibition of pathways emerge. (A) Volcano plot of DEGs comparing 5 dpf MUT to 5 dpf WT samples. (B) Volcano plot of DEPs comparing 5 dpf MUT compared to 5 dpf WT samples. (C) IPA pathway enrichment by patterns of DEGs from 5 dpf MUT compared to WT samples. (D) IPA pathway enrichment by patterns of DEPs from 5 dpf MUT compared to WT samples. (E) Overlap of DEGs with P<0.05 (Wald test) from 5 dpf HT and MUT versus WT samples (purple), and DEPs with P<0.05 (one-way ANOVA) from 5 dpf HT and MUT versus WT samples (green). (F) Overlap of 5 dpf DEGs and DEPs from E and Neuro-GO list. (G) Log₂ FC for selected DEGs and DEPs from overlap in E and F (underlined). *P<0.05, **P<0.01, ***P<0.001.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.