Gene

myh7

ID
ZDB-GENE-991123-5
Name
myosin heavy chain 7
Symbol
myh7 Nomenclature History
Previous Names
  • mg:cb02g011 (1)
  • vmhc (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in embryonic heart tube development and ventricular cardiac myofibril assembly. Predicted to localize to myosin complex. Is expressed in several structures, including heart primordium; heart rudiment; mesoderm; musculature system; and pericardial region. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7).
Genome Resources
Note
None
Expression
All Expression Data
191 figures from 151 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Auman et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myh7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant hyaline body myopathy Alliance Myopathy, myosin storage, autosomal dominant 608358
autosomal recessive hyaline body myopathy Alliance Myopathy, myosin storage, autosomal recessive 255160
dilated cardiomyopathy 1S Alliance Cardiomyopathy, dilated, 1S 613426
dilated cardiomyopathy 1S Alliance Left ventricular noncompaction 5 613426
distal myopathy 1 Alliance Laing distal myopathy 160500
hypertrophic cardiomyopathy 1 Alliance Cardiomyopathy, hypertrophic, 1 192600
scapuloperoneal myopathy Alliance Scapuloperoneal syndrome, myopathic type 181430
Associated With myh7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin IQ motif-containing domain superfamily Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin tail P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QZW1 1938
UniProtKB:Q9PVE1 1938
UniProtKB:C4MRC6 8
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations