Gene
myh7
- ID
- ZDB-GENE-991123-5
- Name
- myosin heavy chain 7
- Symbol
- myh7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within cardiac ventricle development; embryonic heart tube development; and ventricular cardiac myofibril assembly. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including cardiac muscle myoblast; heart primordium; mesoderm; musculature system; and pericardial region. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Orthologous to several human genes including MYH7 (myosin heavy chain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 218 figures from 174 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Auman et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hn2Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa2053 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa5139 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa5718 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa7497 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa10407 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10912 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11779 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15964 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18019 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-myh7 | (2) | |
| CRISPR1-myh7,myh7l | Hesaraki et al., 2022 | |
| CRISPR2-myh7 | (2) | |
| CRISPR4-myh7 | Ouyang et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant hyaline body myopathy | Alliance | Congenital myopathy 7A, myosin storage, autosomal dominant | 608358 |
| autosomal recessive hyaline body myopathy | Alliance | Congenital myopathy 7B, myosin storage, autosomal recessive | 255160 |
| dilated cardiomyopathy 1S | Alliance | Cardiomyopathy, dilated, 1S | 613426 |
| dilated cardiomyopathy 1S | Alliance | Left ventricular noncompaction 5 | 613426 |
| distal myopathy 1 | Alliance | Laing distal myopathy | 160500 |
| hypertrophic cardiomyopathy 1 | Alliance | Cardiomyopathy, hypertrophic, 1 | 192600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA repair protein XRCC4-like, C-terminal | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QZW1 | InterPro | 1938 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.1myh7:GFP) |
|
| 1 | (2) | |
| Tg(-0.5myh7:GFP) |
|
| 1 | (2) | |
| Tg(-0.7myh7:GFP) |
|
| 1 | (2) | |
| Tg(-1.8myh7:EGFP) |
|
| 1 | (3) | |
| Tg(-1.9myh7:EGFP) |
|
| 1 | (5) | |
| Tg(-1.9myh7:GFP) |
|
| 1 | (2) | |
| Tg(3xFLAG-2A-EGFP,myh7:ECFP) |
|
| 1 | Jin et al., 2022 | |
| Tg(myh7:Cre-ERT2) |
|
| 1 | Juan et al., 2024 | |
| Tg(myh7:mCherry-Eco.NfsB) |
|
| 1 | (16) | |
| Tg(UAS:jag2b-2A-Hsa.HIST1H2BJ-ECFP,myh7:mCherry) |
|
| 1 | Jin et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-77A20 | ZFIN Curated Data | |
| Encodes | EST | cb02g011 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001112733 (1) | 5991 nt | ||
| Genomic | GenBank:CR925708 (1) | 229824 nt | ||
| Polypeptide | UniProtKB:F1QZW1 (1) | 1938 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | MYH7 | 14 | Amino acid sequence comparison (2) |
- Ceci, M., Bonvissuto, D., Papetti, F., Silvestri, F., Sette, C., Catalani, E., Cervia, D., Gornati, R., Romano, N. (2024) RACK1 contributes to the upregulation of embryonic genes in a model of cardiac hypertrophy. Scientific Reports. 14:2569825698
- Juan, T., Bellec, M., Cardoso, B., Athéa, H., Fukuda, N., Albu, M., Günther, S., Looso, M., Stainier, D.Y.R. (2024) Control of cardiac contractions using Cre-lox and degron strategies in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 121:e2309842121e2309842121
- Kahsay, A., Dennhag, N., Liu, J.X., Nord, H., Rönnbäck, H., Thorell, A.E., von Hofsten, J., Pedrosa Domellöf, F. (2024) Obscurin Maintains Myofiber Identity in Extraocular Muscles. Investigative ophthalmology & visual science. 65:1919
- Nunes Santos, L., Sousa Costa, Â.M., Nikolov, M., Carvalho, J.E., Coelho Sampaio, A., Stockdale, F.E., Wang, G.F., Andrade Castillo, H., Bortoletto Grizante, M., Dudczig, S., Vasconcelos, M., Rosenthal, N., Jusuf, P.R., Nim, H.T., de Oliveira, P., Guimarães de Freitas Matos, T., Nikovits, W., Tambones, I.L., Figueira, A.C.M., Schubert, M., Ramialison, M., Xavier-Neto, J. (2024) Unraveling the evolutionary origin of the complex Nuclear Receptor Element (cNRE), a cis-regulatory module required for preferential expression in the atrial chamber. Communications biology. 7:371371
- Sam, J., Torregroza, I., Evans, T. (2024) Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis. Development (Cambridge, England). 151(17):
- Weeks, O., Gao, X., Basu, S., Galdieri, J., Chen, K., Burns, C.G., Burns, C.E. (2024) Embryonic alcohol exposure in zebrafish predisposes adults to cardiomyopathy and diastolic dysfunction. Cardiovascular research. 120(13):1607-1621
- Zhu, P., Li, J., Yan, F., Islam, S., Lin, X., Xu, X. (2024) Allelic heterogeneity of TTNtv cardiomyopathy can be modeled in adult zebrafish. JCI insight. 9(7):
- Auman, H.J., Fernandes, I.H., Berríos-Otero, C.A., Colombo, S., Yelon, D. (2023) Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(1):157-172
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- DeMoya, R.A., Forman-Rubinsky, R.E., Fontaine, D., Shin, J., Watkins, S.C., Lo, C.W., Tsang, M. (2023) Sin3a associated protein 130 kDa, sap130, plays an evolutionary conserved role in zebrafish heart development. Frontiers in cell and developmental biology. 11:11971091197109
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