ZFIN ID: ZDB-GENE-991123-5
Gene Name: myosin heavy chain 7
Gene Symbol: myh7    Nomenclature History

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Previous Names: mg:cb02g011 (1), vmhc (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in embryonic heart tube development and ventricular cardiac myofibril assembly. Predicted to localize to myosin complex. Is expressed in several structures, including heart primordium; heart rudiment; mesoderm; musculature system; and pericardial region. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7).
Genome Resources: Alliance (1),  Gene:30616 (1),  Ensembl(GRCz11):ENSDARG00000079564 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2053 Point Mutation Unknown Premature Stop ENU
sa5139 Point Mutation Unknown Splice Site ENU
sa5718 Point Mutation Unknown Premature Stop ENU
sa7497 Point Mutation Unknown Missense ENU
sa10407 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa10912 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11779 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15964 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18019 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18727 Point Mutation Unknown Premature Stop ENU
    sa18728 Point Mutation Unknown Premature Stop ENU
    sa19750 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19751 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19752 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19753 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25806 Point Mutation Unknown Premature Stop ENU
    sa25807 Point Mutation Unknown Premature Stop ENU
    sa32911 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32912 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32913 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sk24 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myh7
    2
    CRISPR2-myh7
    2
    DISEASE ASSOCIATED WITH myh7 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant hyaline body myopathy Alliance Myopathy, myosin storage, autosomal dominant 608358
    autosomal recessive hyaline body myopathy Alliance Myopathy, myosin storage, autosomal recessive 255160
    dilated cardiomyopathy 1S Alliance Cardiomyopathy, dilated, 1S 613426
    Left ventricular noncompaction 5 613426
    distal myopathy 1 Alliance Laing distal myopathy 160500
    hypertrophic cardiomyopathy 1 Alliance Cardiomyopathy, hypertrophic, 1 192600
    scapuloperoneal myopathy Alliance Scapuloperoneal syndrome, myopathic type 181430
    DISEASE ASSOCIATED WITH myh7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ventricular cardiac myofibril assembly (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myh7-201 (1)    Ensembl 5990
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myh7
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-0.1myh7:GFP) myh7 GFP Danio rerio 1 2
    Tg(-0.5myh7:GFP) myh7 GFP Danio rerio 1 2
    Tg(-0.7myh7:GFP) myh7 GFP Danio rerio 1 2
    Tg(-1.8myh7:EGFP) myh7 EGFP Danio rerio 1 2
    Tg(-1.9myh7:EGFP) myh7 EGFP Danio rerio 1 3
    Tg(-1.9myh7:GFP) myh7 GFP Danio rerio 1 2
    Tg(myh7:mCherry-Eco.NfsB) myh7 mCherry Danio rerioEscherichia coli 1 5
    MARKER RELATIONSHIPS
    myh7 Contained in: [BAC] DKEY-77A20 (1) (order this)
    myh7 Encodes: [EST] cb02g011 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001112733 (1) 5991 nt
    Genomic GenBank:BX000358 (1) 181081 nt
    Select Tool
    Polypeptide UniProtKB:F1QZW1 (1) 1938 aa
    Sequence Information (all 12)
    ORTHOLOGY for myh7 ( Chr: 2 )
    CITATIONS (260)