Gene
myh7
- ID
- ZDB-GENE-991123-5
- Name
- myosin heavy chain 7
- Symbol
- myh7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within embryonic heart tube development and ventricular cardiac myofibril assembly. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including heart primordium; heart rudiment; mesoderm; musculature system; and pericardial region. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 216 figures from 173 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Auman et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant hyaline body myopathy | Alliance | Congenital myopathy 7A, myosin storage, autosomal dominant | 608358 |
| autosomal recessive hyaline body myopathy | Alliance | Congenital myopathy 7B, myosin storage, autosomal recessive | 255160 |
| dilated cardiomyopathy 1S | Alliance | Cardiomyopathy, dilated, 1S | 613426 |
| dilated cardiomyopathy 1S | Alliance | Left ventricular noncompaction 5 | 613426 |
| distal myopathy 1 | Alliance | Laing distal myopathy | 160500 |
| hypertrophic cardiomyopathy 1 | Alliance | Cardiomyopathy, hypertrophic, 1 | 192600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA repair protein XRCC4-like, C-terminal | Kinesin motor domain superfamily | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QZW1
|
1938 |
Interactions and Pathways
No data available
Plasmids
No data available