Gene
eif5b
- ID
- ZDB-GENE-050208-20
- Name
- eukaryotic translation initiation factor 5B
- Symbol
- eif5b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be active in cytoplasm. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6912504 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa32742 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32743 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38289 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| zko894a | Allele with one insertion | Unknown | Unknown | CRISPR | |
| zko894b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-eif5b | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR005225 | Small GTP-binding domain |
| Domain | IPR023115 | Translation initiation factor IF- 2, domain 3 |
| Domain | IPR029459 | Elongation factor Tu-type domain |
| Family | IPR015760 | Translation initiation factor IF- 2 |
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Domain Details Per Protein
| Protein | Length | Elongation factor Tu-type domain | P-loop containing nucleoside triphosphate hydrolase | Small GTP-binding domain | Translational (tr)-type GTP-binding domain | Translation initiation factor IF- 2 | Translation initiation factor IF- 2, domain 3 | Translation initiation factor IF-2, domain 3 superfamily | Translation protein, beta-barrel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1QHW9
|
1231 | ||||||||
|
UniProtKB:A0A8M3AKJ3
|
1229 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-254D18 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6912504 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001923538 (1) | 4519 nt | ||
| Genomic | GenBank:BX901938 (1) | 104059 nt | ||
| Polypeptide | UniProtKB:A0A8M1QHW9 (1) | 1231 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lindeman, L.C., Reiner, A.H., Mathavan, S., Aleström, P., and Collas, P. (2010) Tiling histone h3 lysine 4 and 27 methylation in zebrafish using high-density microarrays. PLoS One. 5(12):e15651
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