Gene

grk1a

ID

ZDB-GENE-050823-1

Name

G protein-coupled receptor kinase 1 a

Symbol

grk1a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Exhibits rhodopsin kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of rhodopsin mediated signaling pathway; and visual perception. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Is expressed in epiphysis; eye; retinal photoreceptor layer; and retinal rod cell. Orthologous to human GRK1 (G protein-coupled receptor kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grk1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Oguchi disease-2	Alliance	Oguchi disease-2	613411

Associated With grk1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Domain	IPR016137	RGS domain
Domain	IPR037716	Rhodopsin kinase, catalytic domain
Family	IPR000239	GPCR kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036305	RGS domain superfamily
Homologous_superfamily	IPR044926	RGS, subdomain 2