Gene

grk1a

ID
ZDB-GENE-050823-1
Name
G protein-coupled receptor kinase 1 a
Symbol
grk1a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits rhodopsin kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of rhodopsin mediated signaling pathway; and visual perception. Is expressed in epiphysis; eye; retinal photoreceptor layer; and retinal rod cell. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grk1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Oguchi disease-2 Alliance Oguchi disease-2 613411
Associated With grk1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR016137 RGS domain
Domain IPR037716 Rhodopsin kinase, catalytic domain
Family IPR000239 GPCR kinase
Family IPR032965 Rhodopsin kinase GRK1
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036305 RGS domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal GPCR kinase Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily RGS domain RGS domain superfamily Rhodopsin kinase, catalytic domain Rhodopsin kinase GRK1 Serine/threonine-protein kinase, active site
UniProtKB:Q49HN1 563
UniProtKB:Q1XHM0 563
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-grk1 monoclonal IgG1 Mouse
  • IHC
  • WB
Affinity BioReagents (Thermo Fisher Scientific)
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations