nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Term ID

GO:0000184

Synonyms

mRNA breakdown, nonsense-mediated decay
mRNA catabolic process, nonsense-mediated
mRNA catabolism, nonsense-mediated
mRNA degradation, nonsense-mediated decay
nonsense-mediated mRNA decay
nuclear mRNA catabolic process, nonsense-mediated decay

Definition

The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. 10025395

References

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is a type of: nuclear-transcribed mRNA catabolic process

nuclear-transcribed mRNA catabolic process Show first 5 Terms
has subtype: nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay Show first 5 Terms
negatively regulated by: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Show first 5 Terms
positively regulated by: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Show first 5 Terms
regulated by: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Show first 5 Terms

Phenotype

Phenotype caused by Genes