FIGURE

Fig. 6.

ID

ZDB-FIG-260408-115

Publication

Hancock et al., 2026 - Multi-omic analyses identify molecular targets of Chd7 that contribute to CHARGE syndrome model phenotypes

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Fig. 6.

Knockdown of candidate genes causes phenocopy of CHARGE model phenotypes. All analyses were performed on larvae derived from multiple clutches in a minimum of two independent experiments. (A) Area under the curve (AUC) plotted for each larva's short-latency C-bend (SLC) response frequency. (B) AUC plotted for each larva's long-latency C-bend (LLC) response frequency. (C) Short-term habituation (STH) AUC for each larva's SLC response frequency. (D) STH AUC for each larva's LLC response frequency. (E) Dark-flash response frequency. (F) Light-flash response frequency. (G) Pre-pulse inhibition percentage. Bar graphs in A-G show mean±s.d. (ordinary one-way ANOVA with Dunnetts's multiple comparisons). *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. (H) Frequency of morphological defects observed for each group of larvae [Fisher's exact test with Benjamini–Hochberg false discovery rate (FDR) correction]. *FDR<0.05, **FDR<0.01, ***FDR<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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