ZFIN ID: ZDB-GENE-091117-1
Gene Name: neurofilament, light polypeptide a
Gene Symbol: nefla    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:ch211-222n4.10 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to localize to intermediate filament. Is expressed in nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic lateral sclerosis; and invasive ductal carcinoma. Orthologous to human NEFL (neurofilament light).
Genome Resources: Alliance (1),  Gene:793912 (1),  Ensembl(GRCz11):ENSDARG00000057568 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12368 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45733 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nefla N/A 1
    PHENOTYPE
    Data: Fig. 4 from Wang et al., 2018
    Observed in:
    DISEASE ASSOCIATED WITH nefla HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease dominant intermediate G Alliance Charcot-Marie-Tooth disease, dominant intermediate G 617882
    Charcot-Marie-Tooth disease type 1F Alliance Charcot-Marie-Tooth disease, type 1F 607734
    Charcot-Marie-Tooth disease type 2E Alliance Charcot-Marie-Tooth disease, type 2E 607684
    DISEASE ASSOCIATED WITH nefla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component intermediate filament (more)
    GO Terms (all 1)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nefla-202 (1)    Ensembl 1848
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nefla No data available
    MARKER RELATIONSHIPS
    nefla Contained in: [BAC] CH211-222N4 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021469060 (1)
    Genomic GenBank:CU467622 (1) 128877 nt
    Select Tool
    Polypeptide UniProtKB:E9QFD5 (1) 616 aa
    Sequence Information (all 7)
    ORTHOLOGY for nefla ( Chr: 21 )
    CITATIONS (16)