ZFIN ID: ZDB-GENE-990415-54
CITATIONS (71 total)
Gene Name: empty spiracles homeobox 2
Gene Symbol: emx2
Trejo-Reveles, V., Owen, N., Ching Chan, B.H., Toms, M., Schoenebeck, J.J., Moosajee, M., Rainger, J., Genomics England Research Consortium (2023) Identification of Novel Coloboma Candidate Genes through Conserved Gene Expression Analyses across Four Vertebrate Species. Biomolecules. 13(2):
Chen, X., Zhang, Q., Lin, J., Zhang, Y., Zhang, Y., Gui, Y., Zhang, R., Liu, T., Li, Q. (2022) The tissue-specificity associated region and motif of an emx2 downstream enhancer CNE2.04 in zebrafish. Gene expression patterns : GEP. 45:119269
Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
Fabian, P., Tseng, K.C., Thiruppathy, M., Arata, C., Chen, H.J., Smeeton, J., Nelson, N., Crump, J.G. (2022) Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nature communications. 13:13
Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
Messina, A., Potrich, D., Schiona, I., Sovrano, V.A., Fraser, S.E., Brennan, C.H., Vallortigara, G. (2021) Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual Numerosity. Cerebral cortex (New York, N.Y. : 1991). 32(2):418-428
Kozak, E.L., Palit, S., Miranda-Rodríguez, J.R., Janjic, A., Böttcher, A., Lickert, H., Enard, W., Theis, F.J., López-Schier, H. (2020) Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2. Current biology : CB. 30(6):1142-1151.e6
Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
Ohta, S., Ji, Y.R., Martin, D., Wu, D.K. (2020) Emx2 regulates hair cell rearrangement but not positional identity within neuromasts. eLIFE. 9:
Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
Chen, T., Zhang, B., Ziegenhals, T., Prusty, A.B., Fröhler, S., Grimm, C., Hu, Y., Schaefke, B., Fang, L., Zhang, M., Kraemer, N., Kaindl, A.M., Fischer, U., Chen, W. (2019) A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLoS Genetics. 15:e1008460
Jacobo, A., Dasgupta, A., Erzberger, A., Siletti, K., Hudspeth, A.J. (2019) Notch-Mediated Determination of Hair-Bundle Polarity in Mechanosensory Hair Cells of the Zebrafish Lateral Line. Current biology : CB. 29(21):3579-3587.e7
Reuter, I., Jäckels, J., Kneitz, S., Kuper, J., Lesch, K.P., Lillesaar, C. (2019) Fgf3 is crucial for the generation of monoaminergic cerebrospinal fluid contacting cells in zebrafish. Biology Open. 8(6):
Ji, Y.R., Warrier, S., Jiang, T., Wu, D.K., Kindt, K. (2018) Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells. eLIFE. 7
Lozano-Ortega, M., Valera, G., Xiao, Y., Faucherre, A., López-Schier, H. (2018) Hair cell identity establishes labeled lines of directional mechanosensation. PLoS Biology. 16:e2004404
Askary, A., Xu, P., Barske, L., Bay, M., Bump, P., Balczerski, B., Bonaguidi, M.A., Crump, J.G. (2017) Genome-wide analysis of facial skeletal regionalization in zebrafish. Development (Cambridge, England). 144(16):2994-3005
Jiang, T., Kindt, K., Wu, D.K. (2017) Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells. eLIFE. 6
Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
Muthu, V., Eachus, H., Ellis, P., Brown, S., Placzek, M. (2016) Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus. Development (Cambridge, England). 143(14):2651-63
Shi, W., Chen, X., Wang, F., Gao, M., Yang, Y., Du, Z., Wang, C., Yao, Y., He, K., Hao, A. (2016) ZDHHC16 Modulates FGF/ERK Dependent Proliferation of Neural Stem/Progenitor Cells in the Zebrafish Telencephalon. Developmental Neurobiology. 76(9):1014-28
Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U. (2015) Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. The Journal of comparative neurology. 523(8):1202-21
Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
Ganz, J., Kroehne, V., Freudenreich, D., Machate, A., Geffarth, M., Braasch, I., Kaslin, J., Brand, M. (2014) Subdivisions of the adult zebrafish pallium based on molecular marker analysis. F1000Research. 3:308
Lauter, G., Söll, I., and Hauptmann, G. (2013) Molecular characterization of prosomeric and intraprosomeric subdivisions of the embryonic zebrafish diencephalon. The Journal of comparative neurology. 521(5):1093-1118
MacDonald, R.B., Pollack, J.N., Debiais-Thibaud, M., Heude, E., Talbot, J.C., and Ekker, M. (2013) The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon. Developmental Biology. 381(1):276-85
Wolf, A., and Ryu, S. (2013) Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Development (Cambridge, England). 140(8):1762-1773
Filippi, A., Jainok, C., and Driever, W. (2012) Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development. Developmental Biology. 369(1):133-149
Ganz, J., Kaslin, J., Freudenreich, D., Machate, A., Geffarth, M., and Brand, M. (2012) Subdivisions of the adult zebrafish subpallium by molecular marker analysis. The Journal of comparative neurology. 520(3):633-55
Ma, D., Wang, L., Wang, S., Gao, Y., Wei, Y., and Liu, F. (2012) Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(51):21040-21045
Lauter, G., Söll, I., and Hauptmann, G. (2011) Multicolor fluorescent in situ hybridization to define abutting and overlapping gene expression in the embryonic zebrafish brain. Neural Development. 6:10
Li, Q., Ritter, D., Yang, N., Dong, Z., Li, H., Chuang, J.H., and Guo, S. (2010) A systematic approach to identify functional motifs within vertebrate developmental enhancers. Developmental Biology. 337(2):484-495
Rhodes, J.M., Bentley, F.K., Print, C.G., Dorsett, D., Misulovin, Z., Dickinson, E.J., Crosier, K.E., Crosier, P.S., and Horsfield, J.A. (2010) Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved. Developmental Biology. 344(2):637-649
Paridaen, J.T., Danesin, C., Elas, A.T., van de Water, S., Houart, C., and Zivkovic, D. (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Developmental Biology. 331(2):101-112
Viktorin, G., Chiuchitu, C., Rissler, M., Varga, Z.M., and Westerfield, M. (2009) Emx3 is required for the differentiation of dorsal telencephalic neurons. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(8):1984-1998
Scholpp, S., Foucher, I., Staudt, N., Peukert, D., Lumsden, A., and Houart, C. (2007) Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development (Cambridge, England). 134(17):3167-3176
Tessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H., and Arendt, D. (2007) Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution. Cell. 129(7):1389-1400
Lee, J.E., Wu, S.F., Goering, L.M., and Dorsky, R.I. (2006) Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. Development (Cambridge, England). 133(22):4451-4461
Mione, M., Lele, Z., Kwong, C.T., Concha, M.L., and Clarke, J.D. (2006) Expression of pcp4a in subpopulations of CNS neurons in zebrafish. The Journal of comparative neurology. 495(6):769-787
Scholpp, S., Wolf, O., Brand, M., and Lumsden, A. (2006) Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon. Development (Cambridge, England). 133(5):855-864
Stigloher, C., Ninkovic, J., Laplante, M., Geling, A., Tannhauser, B., Topp, S., Kikuta, H., Becker, T.S., Houart, C., and Bally-Cuif, L. (2006) Segregation of telencephalic and eye-field identities inside the zebrafish forebrain territory is controlled by Rx3. Development (Cambridge, England). 133(15):2925-2935
Kapsimali, M., Caneparo, L., Houart, C., and Wilson, S.W. (2004) Inhibition of Wnt/Axin/{beta}-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity. Development (Cambridge, England). 131(23):5923-5933
Plouhinec, J.L., Granier, C., Le Mentec, C., Lawson, K.A., Saberan-Djoneidi, D., Aghion, J., Shi, D.L., Collignon, J., and Mazan, S. (2004) Identification of the mammalian Not gene via a phylogenomic approach. Gene expression patterns : GEP. 5(1):11-22
Kawahara, A. and Dawid, I.B. (2002) Developmental expression of zebrafish emx1 during early embryogenesis. Gene expression patterns : GEP. 2(3-4):201-206
Mathieu, J., Barth, A., Rosa, F.M., Wilson, S.W., and Peyriéras, N. (2002) Distinct and cooperative roles for Nodal and Hedgehog signals during hypothalamic development. Development (Cambridge, England). 129(13):3055-3065
Minguillón, C., Ferrier, D.E., Cebrián, C., and Garcia-Fernàndez, J. (2002) Gene duplications in the prototypical cephalochordate amphioxus. Gene. 287(1-2):121-128
Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
Kobayashi, M., Toyama, R., Takeda, H., Dawid, I.B., and Kawakami, K. (1998) Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (Cambridge, England). 125:2973-2982
Patarnello, T., Bargelloni, L., Boncinelli, E., Spada, F., Pannese, M., and Broccoli, V. (1997) Evolution of Emx genes and brain development in vertebrates. Proceedings. Biological sciences. 264:1763-1766
Morita, T., Nitta, H., Kiyama, Y., Mori, H., and Mishina, M. (1995) Differential expression of two zebrafish emx homeoprotein mRNAs in the developing brain. Neuroscience letters. 198:131-134
Additional Citations (22):
ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.
ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.
ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.
ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.
UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.
ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.
UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.
Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.
GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.
ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.
Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.
ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.
Thisse, C., and Thisse, B. (2005) High Throughput Expression Analysis of ZF-Models Consortium Clones. ZFIN Direct Data Submission.
Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.
ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.
Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.
ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.
ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.
ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.
ZFIN Staff (2002) Scientific Curation. Manually curated data.
ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.
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