ZFIN ID: ZDB-PUB-151216-3
ZDHHC16 Modulates FGF/ERK Dependent Proliferation of Neural Stem/Progenitor Cells in the Zebrafish Telencephalon
Shi, W., Chen, X., Wang, F., Gao, M., Yang, Y., Du, Z., Wang, C., Yao, Y., He, K., Hao, A.
Date: 2016
Source: Developmental Neurobiology   76(9): 1014-28 (Journal)
Registered Authors:
Keywords: FGF/ERK, ZDHHC16, neural stem/progenitor cell, palmitoylation, telencephalon
MeSH Terms:
  • Acyltransferases/genetics
  • Acyltransferases/physiology*
  • Animals
  • Cell Proliferation/genetics
  • Cell Proliferation/physiology*
  • Embryo, Nonmammalian
  • Fibroblast Growth Factors/physiology*
  • Gene Expression Regulation, Developmental/genetics
  • Gene Expression Regulation, Developmental/physiology*
  • MAP Kinase Signaling System/physiology*
  • Mice
  • Neural Stem Cells/physiology*
  • Telencephalon/physiology*
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/physiology*
PubMed: 26663717 Full text @ Dev. Neurobiol.
In vertebrates, neural stem/progenitor cells (NSPCs) maintenance is critical for nervous system development and homeostasis. However, the molecular mechanisms underlying the maintenance of NSPCs have not been fully elucidated. Here, we demonstrated that zebrafish ZDHHC16, a DHHC encoding protein, which was related to protein palmitoylation after translation, was expressed in the developing forebrain, and especially in the telencephalon. Loss- and gain-of-function studies showed that ZDHHC16 played a crucial role in the regualtion of NSPCs proliferation during zebrafish telencephalic development, via a mechanism dependent on its palmitoyltransferase activity. Further analyses showed that the inhibition of ZDHHC16 led to inactivation of the FGF/ERK signaling pathway during telencephalic NSPCs proliferation and maintenance. Taken together, our results suggest that ZDHHC16 activity is essential for early NSPCs proliferation where it acts to activate the FGF/ERK network, allowing for the initiation of proliferation -regulated gene expression programs. This article is protected by copyright. All rights reserved.