PUBLICATION
Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution
- Authors
- Tessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H., and Arendt, D.
- ID
- ZDB-PUB-070711-25
- Date
- 2007
- Source
- Cell 129(7): 1389-1400 (Journal)
- Registered Authors
- Arendt, Detlev, Raible, Florian, Rembold, Martina
- Keywords
- none
- MeSH Terms
-
- Evolution, Molecular
- Transcription Factors/genetics
- Conserved Sequence/genetics
- Neuropeptides/metabolism
- Microscopy, Electron, Transmission
- Biological Evolution*
- Species Specificity
- Neurosecretion/physiology
- Annelida/anatomy & histology
- Annelida/physiology*
- Neurons, Afferent/metabolism*
- Neurons, Afferent/ultrastructure
- Zebrafish/anatomy & histology
- Zebrafish/physiology*
- Biomarkers/metabolism
- Hypothalamus/metabolism*
- Hypothalamus/ultrastructure
- Neurosecretory Systems/metabolism*
- Neurosecretory Systems/ultrastructure
- Animals
- Vasotocin/metabolism
- MicroRNAs/genetics
- PubMed
- 17604726 Full text @ Cell
Citation
Tessmar-Raible, K., Raible, F., Christodoulou, F., Guy, K., Rembold, M., Hausen, H., and Arendt, D. (2007) Conserved sensory-neurosecretory cell types in annelid and fish forebrain: insights into hypothalamus evolution. Cell. 129(7):1389-1400.
Abstract
Neurosecretory control centers form part of the forebrain in many animal phyla, including vertebrates, insects, and annelids. The evolutionary origin of these centers is largely unknown. To identify conserved, and thus phylogenetically ancient, components of neurosecretory brain centers, we characterize and compare neurons that express the prohormone vasotocin (vasopressin/oxytocin)-neurophysin in the developing forebrain of the annelid Platynereis dumerilii and of the zebrafish. These neurons express the same tissue-restricted microRNA, miR-7, and conserved, cell-type-specific combinations of transcription factors (nk2.1, rx, and otp) that specify their identity, as evidenced by the specific requirement of zebrafish rx3 for vasotocin-neurophysin expression. MiR-7 also labels another shared population of neurons containing RFamides. Since the vasotocinergic and RFamidergic neurons appear to be directly sensory in annelid and fish, we propose that cell types with dual sensory-neurosecretory properties were the starting point for the evolution of neurosecretory brain centers in Bilateria.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping