Gene
emx2
- ID
- ZDB-GENE-990415-54
- Name
- empty spiracles homeobox 2
- Symbol
- emx2 Nomenclature History
- Previous Names
-
- fk69b03
- wu:fk69b03 (1)
- zgc:109855
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within brain development; neuromast hair cell morphogenesis; and vestibular receptor cell stereocilium organization. Predicted to be active in nucleus. Is expressed in several structures, including midbrain neural tube; nervous system; periderm; pharyngeal arch; and presumptive diencephalon. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to human EMX2 (empty spiracles homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 27 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109855 (15 images)
- eu131 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Schizencephaly | 269160 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EMX/VAX/Noto Homeobox Transcription Factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QF78 | InterPro | 176 | ||||||
| UniProtKB:Q568U8 | InterPro | 247 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-emx2 | polyclonal | Rabbit |
|
Trans Genic, Inc.
|
8 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-79E7 | ZFIN Curated Data | |
| Encodes | EST | eu131 | Thisse et al., 2005 | |
| Encodes | EST | fk69b03 | ||
| Encodes | cDNA | MGC:109855 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192278 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131280 (1) | 1614 nt | ||
| Genomic | GenBank:AL929298 (2) | 178487 nt | ||
| Polypeptide | UniProtKB:Q568U8 (1) | 247 aa |
- Ono, K., Jarysta, A., Hughes, N.C., Jukic, A., Chang, H.H.V., Deans, M.R., Eatock, R.A., Cullen, K.E., Kindt, K.S., Tarchini, B. (2024) Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function. eLIFE. 13:
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Trejo-Reveles, V., Owen, N., Ching Chan, B.H., Toms, M., Schoenebeck, J.J., Moosajee, M., Rainger, J., Genomics England Research Consortium (2023) Identification of Novel Coloboma Candidate Genes through Conserved Gene Expression Analyses across Four Vertebrate Species. Biomolecules. 13(2):
- Chen, X., Zhang, Q., Lin, J., Zhang, Y., Zhang, Y., Gui, Y., Zhang, R., Liu, T., Li, Q. (2022) The tissue-specificity associated region and motif of an emx2 downstream enhancer CNE2.04 in zebrafish. Gene expression patterns : GEP. 45:119269
- Doretto, L.B., Butzge, A.J., Nakajima, R.T., Martinez, E.R.M., de Souza, B.M., Rodrigues, M.D.S., Rosa, I.F., Ricci, J.M.B., Tovo-Neto, A., Costa, D.F., Malafaia, G., Shao, C., Nóbrega, R.H. (2022) Gdnf Acts as a Germ Cell-Derived Growth Factor and Regulates the Zebrafish Germ Stem Cell Niche in Autocrine- and Paracrine-Dependent Manners. Cells. 11(8):
- Fabian, P., Tseng, K.C., Thiruppathy, M., Arata, C., Chen, H.J., Smeeton, J., Nelson, N., Crump, J.G. (2022) Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nature communications. 13:13
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Messina, A., Potrich, D., Schiona, I., Sovrano, V.A., Fraser, S.E., Brennan, C.H., Vallortigara, G. (2021) Neurons in the Dorso-Central Division of Zebrafish Pallium Respond to Change in Visual Numerosity. Cerebral cortex (New York, N.Y. : 1991). 32(2):418-428
- Kozak, E.L., Palit, S., Miranda-Rodríguez, J.R., Janjic, A., Böttcher, A., Lickert, H., Enard, W., Theis, F.J., López-Schier, H. (2020) Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2. Current biology : CB. 30(6):1142-1151.e6
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
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