Gene

emx2

ID

ZDB-GENE-990415-54

Name

empty spiracles homeobox 2

Symbol

emx2 Nomenclature History

Previous Names

fk69b03
wu:fk69b03 (1)
zgc:109855

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in brain development and vestibular receptor cell stereocilium organization. Predicted to localize to nucleus. Is expressed in several structures, including midbrain neural tube; nervous system; periderm; pharyngeal arch; and presumptive diencephalon. Orthologous to human EMX2 (empty spiracles homeobox 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

42 figures from 24 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:109855 (15 images)
eu131 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With emx2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Schizencephaly	269160

Associated With emx2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR050877	EMX/VAX/Noto Homeobox Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily