ZFIN

ZFIN ID: ZDB-GENE-990415-223

ZFIN ID: ZDB-GENE-990415-223

CITATIONS (77 total)

Gene Name:	frizzled class receptor 7a
Gene Symbol:	fzd7a

Kocere, A., Chiavacci, E., Soneson, C., Jacobson, S.T., Harrison, E.N., Méndez-Acevedo, K.M., MacGowan, J.S., Wells, H.H., Hiltabidle, M.S., Raghunath, A., Shavit, J.A., Panáková, D., Williams, M.L.K., Robinson, M.D., Mosimann, C., Burger, A. (2025) Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signaling. Developmental Biology. :

Ma, Y., Qiu, S.W., Wang, W.Q., Feng, H.F., Zheng, L., Wei, G.G., Nie, H.Y., Yang, J.Y., Chen, Y.J., Dai, P., Gao, X., Yuan, Y.Y. (2025) Functional characterization of MFSD3 in auditory system and zebrafish embryogenesis. Frontiers in genetics. 16:16344931634493

Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579

Yu, E.P.Y., Saxena, V., Perin, S., Ekker, M. (2023) Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology. Biomolecules. 13(9):

Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089

Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):

Gao, X., Huang, S.S., Qiu, S.W., Su, Y., Wang, W.Q., Xu, H.Y., Xu, J.C., Kang, D.Y., Dai, P., Yuan, Y.Y. (2020) Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms. Journal of Medical Genetics. 58(7):465-474

Schauer, A., Pinheiro, D., Hauschild, R., Heisenberg, C.P. (2020) Zebrafish embryonic explants undergo genetically encoded self-assembly. eLIFE. 9:

Williams, M.L.K., Solnica-Krezel, L. (2020) Nodal and Planar Cell Polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. eLIFE. 9:

Zheng, C., Shan, L., Tong, P., Efferth, T. (2020) Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish. Dose-response : a publication of International Hormesis Society. 18:1559325819897180

Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117

Grainger, S., Nguyen, N., Richter, J., Setayesh, J., Lonquich, B., Oon, C.H., Wozniak, J.M., Barahona, R., Kamei, C.N., Houston, J., Carrillo-Terrazas, M., Drummond, I.A., Gonzalez, D., Willert, K., Traver, D. (2019) EGFR is required for Wnt9a-Fzd9b signalling specificity in haematopoietic stem cells. Nature cell biology. 21(6):721-730

Kamei, C.N., Gallegos, T.F., Liu, Y., Hukriede, N., Drummond, I.A. (2019) Wnt signaling mediates new nephron formation during zebrafish kidney regeneration. Development (Cambridge, England). 146(8):

Navajas Acedo, J., Voas, M.G., Alexander, R., Woolley, T., Unruh, J.R., Li, H., Moens, C., Piotrowski, T. (2019) PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation. Nature communications. 10:3993

Xue, Y., Liu, D., Cui, G., Ding, Y., Ai, D., Gao, S., Zhang, Y., Suo, S., Wang, X., Lv, P., Zhou, C., Li, Y., Chen, X., Peng, G., Jing, N., Han, J.J., Liu, F. (2019) A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis. Cell Reports. 27:1567-1578.e5

Čapek, D., Smutny, M., Tichy, A.M., Morri, M., Janovjak, H., Heisenberg, C.P. (2019) Light-activated Frizzled7 reveals a permissive role of non-canonical Wnt signaling in mesendoderm cell migration. eLIFE. 8:

Du, Z., Ma, H.L., Zhang, Z.Y., Zheng, J.W., Wang, Y.A. (2018) Transgenic Expression of A Venous Malformation Related Mutation, TIE2-R849W, Significantly Induces Multiple Malformations of Zebrafish.. International journal of medical sciences. 15:385-394

Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161

Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275

Shitasako, S., Ito, Y., Ito, R., Ueda, Y., Shimizu, Y., Ohshima, T. (2017) Wnt and Shh signals regulate neural stem cell proliferation and differentiation in the optic tectum of adult zebrafish. Developmental Neurobiology. 77(10):1206-1220

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Brinkmann, E.M., Mattes, B., Kumar, R., Hagemann, A.I., Gradl, D., Scholpp, S., Steinbeisser, H., Kaufmann, L.T., Ozbek, S. (2016) Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation. The Journal of biological chemistry. 291(26):13730-42

Coppola, U., Annona, G., D'Aniello, S., Ristoratore, F. (2016) Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. BMC Evolutionary Biology. 16:26

Hu, Y., Xie, S., Yao, J. (2016) Identification of Novel Reference Genes Suitable for qRT-PCR Normalization with Respect to the Zebrafish Developmental Stage. PLoS One. 11:e0149277

Sepich, D.S., Solnica-Krezel, L. (2016) Intracellular Golgi Complex Organization Reveals Tissue Specific Polarity during Zebrafish Embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 245(6):678-91

Baranowska Körberg, I., Hofmeister, W., Markljung, E., Cao, J., Nilsson, D., Ludwig, M., Draaken, M., Holmdahl, G., Barker, G., Reutter, H., Vukojević, V., Clementson Kockum, C., Lundin, J., Lindstrand, A., Nordenskjöld, A. (2015) WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish. Human molecular genetics. 24(18):5069-78

Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61

Roszko, I., Sepich, D., Jessen, J.R., Chandrasekhar, A., Solnica-Krezel, L. (2015) A dynamic intracellular distribution of Vangl2 accompanies cell polarization during zebrafish gastrulation. Development (Cambridge, England). 142(14):2508-20

Gfrerer, L., Shubinets, V., Hoyos, T., Kong, Y., Nguyen, C., Pietschmann, P., Morton, C.C., Maas, R.L., Liao, E.C. (2014) Functional Analysis of SPECC1L in Craniofacial Development and Oblique Facial Cleft Pathogenesis. Plastic and reconstructive surgery. 134:748-759

Dohn, M.R., Mundell, N.A., Sawyer, L.M., Dunlap, J.A., and Jessen, J.R. (2013) Planar cell polarity proteins differentially regulate extracellular matrix organization and assembly during zebrafish gastrulation. Developmental Biology. 383(1):39-51

Kamel, G., Hoyos, T., Rochard, L., Dougherty, M., Tse, W., Shubinets, V., Grimaldi, M., and Liao, E.C. (2013) Requirement for frzb and fzd7a in cranial neural crest convergence and extension mechanisms during zebrafish palate and jaw morphogenesis. Developmental Biology. 381(2):423-33

Li, X., Roszko, I., Sepich, D.S., Ni, M., Hamm, H.E., Marlow, F.L., and Solnica-Krezel, L. (2013) Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development (Cambridge, England). 140(14):3028-3039

Nikaido, M., Law, E.W., and Kelsh, R.N. (2013) A Systematic Survey of Expression and Function of Zebrafish frizzled Genes. PLoS One. 8(1):e54833

Yang, H., Zhou, Y., Gu, J., Xie, S., Xu, Y., Zhu, G., Wang, L., Huang, J., Ma, H., and Yao, J. (2013) Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS One. 8(5):e64058

Lu, F.I., Thisse, C., and Thisse, B. (2011) Identification and mechanism of regulation of the zebrafish dorsal determinant. Proceedings of the National Academy of Sciences of the United States of America. 108(38):15876-80

Quesada-Hernández, E., Caneparo, L., Schneider, S., Winkler, S., Liebling, M., Fraser, S.E., and Heisenberg, C.P. (2010) Stereotypical Cell Division Orientation Controls Neural Rod Midline Formation in Zebrafish. Current biology : CB. 20(21):1966-1972

Segalen, M., Johnston, C.A., Martin, C.A., Dumortier, J.G., Prehoda, K.E., David, N.B., Doe, C.Q., and Bellaiche, Y. (2010) The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish. Developmental Cell. 19(5):740-752

Sisson, B.E., and Topczewski, J. (2009) Expression of five frizzleds during zebrafish craniofacial development. Gene expression patterns : GEP. 9(7):520-527

Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S. (2009) Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution. 219(6):289-300

Snelson, C.D., Santhakumar, K., Halpern, M.E., and Gamse, J.T. (2008) Tbx2b is required for the development of the parapineal organ. Development (Cambridge, England). 135(9):1693-1702

Witzel, S., Zimyanin, V., Carreira-Barbosa, F., Tada, M., and Heisenberg, C.P. (2006) Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. The Journal of cell biology. 175(5):791-802

Fong, S.H., Emelyanov, A., Teh, C., and Korzh, V. (2005) Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate. Development (Cambridge, England). 132(16):3587-3596

Katoh, M., and Katoh, M. (2005) Comparative genomics on Fzd7 orthologs. International journal of molecular medicine. 15(6):1051-1055

Knowlton, M.N. and Kelly, G.M. (2004) Zebrafish Mir Antagonizes Frizzled 7-Induced Gastrulation Defects. Zebrafish. 1(2):133-144

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Sumanas, S., Kim, H.J., Hermanson, S.B., and Ekker, S.C. (2002) Lateral line, nervous system, and maternal expression of Frizzled 7a during zebrafish embryogenesis. Mechanisms of Development. 115(1-2):107-111

Ungar, A. and Calvey, C. (2002) Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm. Mechanisms of Development. 118(102):165-169

El-Messaoudi, S. and Renucci, A. (2001) Expression pattern of the frizzled 7 gene during zebrafish embryonic development. Mechanisms of Development. 102(1-2):231-234

Wang, Y., Macke, J.P., Abella, B.S., Andreasson, K., Worley, P., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., and Nathans, J. (1996) A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. The Journal of biological chemistry. 271(8):4468-4476

Additional Citations (28):

Zebrafish Nomenclature Committee (2026) Nomenclature Data Curation (2026). Nomenclature Committee Submission.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

Zebrafish Nomenclature Committee (2022) Nomenclature Data Curation (2022). Nomenclature Committee Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

Zebrafish Nomenclature Committee (2018) Nomenclature Data Curation (2018). Nomenclature Committee Submission.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., Winkler, S., Brand, M., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource, MPI Dresden, and Hubrecht laboratory. ZFIN Direct Data Submission.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZF-MODELS Consortium (2007) ZF-MODELS Consortium and Zebrafish Mutation Resource targeted knock-out mutants. ZFIN Direct Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Ensembl curators, GOA curators (2006) Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, C., and Thisse, B. (2005) High Throughput Expression Analysis of ZF-Models Consortium Clones. ZFIN Direct Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2003) Computational Sequence to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.

Kudoh, T., Tsang, M., Hukriede, N.A., Chen, X., Dedekian, M., Clarke, C.J., Kiang, A., Schultz, S., Epstein, J.A., Toyama, R., and Dawid, I.B. (2001) A gene expression screen in zebrafish embryogenesis. ZFIN Direct Data Submission.