Gene
fzd7a
- ID
- ZDB-GENE-990415-223
- Name
- frizzled class receptor 7a
- Symbol
- fzd7a Nomenclature History
- Previous Names
-
- fz7
- zg07
- id:ibd2735 (1)
- wu:fc17e10
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in chondrocyte proliferation; epiboly; and gastrulation. Localizes to plasma membrane. Is expressed in several structures, including margin; mesenchyme; nervous system; neural tube; and pharyngeal arch. Orthologous to human FZD7 (frizzled class receptor 7).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 36 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:85603 (20 images)
- eu262 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
e3 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
ihb633 | Allele with one delins | Unknown | Unknown | CRISPR | |
ihb634 | Allele with one delins | Unknown | Unknown | CRISPR | |
sa10339 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sdu5 | Allele with one delins | Exon 1 | Unknown | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Frizzled cysteine-rich domain superfamily | Frizzled domain | Frizzled/secreted frizzled-related protein | Frizzled/Smoothened, 7TM | GPCR, family 2-like, 7TM |
---|---|---|---|---|---|---|
UniProtKB:Q90ZT3
|
559 | |||||
UniProtKB:Q6NV44
|
559 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-62A12 | ZFIN Curated Data | |
Encodes | EST | eu262 | Thisse et al., 2005 | |
Encodes | EST | fc17e10 | ||
Encodes | EST | ibd2735 | ZFIN Curated Data | |
Encodes | cDNA | MGC:65759 | ZFIN Curated Data | |
Encodes | cDNA | MGC:85603 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131139 (1) | 2735 nt | ||
Genomic | GenBank:CR407547 (2) | 204067 nt | ||
Polypeptide | UniProtKB:Q6NV44 (1) | 559 aa |
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Yu, E.P.Y., Saxena, V., Perin, S., Ekker, M. (2023) Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology. Biomolecules. 13(9):
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Chen, J.W., Niu, X., King, M.J., Noedl, M.T., Tabin, C.J., Galloway, J.L. (2020) The mevalonate pathway is a critical regulator of tendon cell specification. Development (Cambridge, England). 147(12):
- Gao, X., Huang, S.S., Qiu, S.W., Su, Y., Wang, W.Q., Xu, H.Y., Xu, J.C., Kang, D.Y., Dai, P., Yuan, Y.Y. (2020) Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms. Journal of Medical Genetics. 58(7):465-474
- Schauer, A., Pinheiro, D., Hauschild, R., Heisenberg, C.P. (2020) Zebrafish embryonic explants undergo genetically encoded self-assembly. eLIFE. 9:
- Williams, M.L.K., Solnica-Krezel, L. (2020) Nodal and Planar Cell Polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. eLIFE. 9:
- Zheng, C., Shan, L., Tong, P., Efferth, T. (2020) Cardiotoxicity and Cardioprotection by Artesunate in Larval Zebrafish. Dose-response : a publication of International Hormesis Society. 18:1559325819897180
- Čapek, D., Smutny, M., Tichy, A.M., Morri, M., Janovjak, H., Heisenberg, C.P. (2019) Light-activated Frizzled7 reveals a permissive role of non-canonical Wnt signaling in mesendoderm cell migration. eLIFE. 8:
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
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