PUBLICATION
A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled
- Authors
- Wang, Y., Macke, J.P., Abella, B.S., Andreasson, K., Worley, P., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., and Nathans, J.
- ID
- ZDB-PUB-961101-17
- Date
- 1996
- Source
- The Journal of biological chemistry 271(8): 4468-4476 (Journal)
- Registered Authors
- Wang, Yihong
- Keywords
- none
- MeSH Terms
-
- Chickens
- Receptors, Cell Surface/biosynthesis
- Receptors, Cell Surface/chemistry*
- Frizzled Receptors
- Amino Acid Sequence
- Central Nervous System/embryology
- Central Nervous System/growth & development
- Central Nervous System/metabolism
- Mammals
- Caenorhabditis elegans
- Genes, Insect*
- DNA, Complementary
- Nematoda/metabolism
- Multigene Family*
- Receptors, G-Protein-Coupled/biosynthesis
- Receptors, G-Protein-Coupled/chemistry
- In Situ Hybridization
- Mice
- Introns
- Membrane Proteins/biosynthesis
- Membrane Proteins/chemistry*
- Membrane Proteins/genetics*
- Drosophila melanogaster/genetics
- Drosophila melanogaster/metabolism*
- Embryonic and Fetal Development
- DNA Primers
- Chromosome Mapping
- Humans
- Sea Urchins
- Zebrafish
- Polymerase Chain Reaction
- Molecular Sequence Data
- Sequence Homology, Amino Acid
- Protein Structure, Secondary
- Base Sequence
- Insect Hormones/biosynthesis
- Insect Hormones/chemistry*
- Rats
- Drosophila Proteins*
- Animals
- Exons
- Cloning, Molecular
- PubMed
- 8626800 Full text @ J. Biol. Chem.
Citation
Wang, Y., Macke, J.P., Abella, B.S., Andreasson, K., Worley, P., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., and Nathans, J. (1996) A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. The Journal of biological chemistry. 271(8):4468-4476.
Abstract
In Drosophila melanogaster, the frizzled gene plays an essential role in the development of tissue polarity as assessed by the orientation of cuticular structures. Through a combination of random cDNA sequencing, degenerate polymerase chain reaction amplification, and low stringency hybridization we have identified six novel frizzled homologues from mammals, at least 11 from zebrafish, several from chicken and sea urchin, and one from Caenorhabditis elegans. The complete deduced amino acid sequences of the mammalian and nematode homologues share with the Drosophila frizzled protein a conserved amino-terminal cysteine-rich domain and seven putative transmembrane segments. Each of the mammalian homologues is expressed in a distinctive set of tissues in the adult, and at least three are expressed during embryogenesis. As hypothesized for the Drosophila frizzled protein, the frizzled homologues are likely to act as transmembrane receptors for as yet unidentified ligands. These observations predict the existence of a family of signal transduction pathways that are homologous to the pathway that determines tissue polarity in Drosophila.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping