PUBLICATION
Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family
- Authors
- Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S.
- ID
- ZDB-PUB-090706-13
- Date
- 2009
- Source
- Development genes and evolution 219(6): 289-300 (Journal)
- Registered Authors
- Chong, Samuel, Venkatesh, Byrappa, Winkler, Christoph
- Keywords
- Twist, Zebrafish, Medaka, Phylogeny, Orthology, Synteny, Expression, Regulation
- MeSH Terms
-
- Animals
- Embryo, Nonmammalian/metabolism
- Evolution, Molecular*
- Fishes/genetics
- Gene Expression Regulation, Developmental*
- Phylogeny
- Sequence Alignment
- Twist-Related Protein 1/genetics*
- Zebrafish/embryology
- Zebrafish/genetics*
- Zebrafish Proteins/genetics*
- PubMed
- 19565261 Full text @ Dev. Genes Evol.
Citation
Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S. (2009) Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution. 219(6):289-300.
Abstract
Four members of the twist gene family (twist1a, 1b, 2, and 3) are found in the zebrafish, and they are thought to have arisen through three rounds of gene duplication, two of which occurred prior to the tetrapod-fish split. Phylogenetic analysis groups most of the vertebrate Twist1 peptides into clade I, except for the Twist1b proteins of the acanthopterygian fish (medaka, pufferfish, stickleback), which clustered within clade III. Paralogies and orthologies among the zebrafish, medaka, and human twist genes were determined using comparative synteny analysis of the chromosomal regions flanking these genes. Comparative nucleotide substitution analyses also revealed a faster rate of nucleotide mutation/substitution in the acanthopterygian twist1b compared to the zebrafish twist1b, thus accounting for their anomalous phylogenetic clustering. We also observed minimal expression overlap among the four twist genes, suggesting that despite their significant peptide similarity, their regulatory controls have diverged considerably, with minimal functional redundancy between them.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping