PUBLICATION
Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm
- Authors
- Ungar, A. and Calvey, C.
- ID
- ZDB-PUB-021015-6
- Date
- 2002
- Source
- Mechanisms of Development 118(102): 165-169 (Journal)
- Registered Authors
- Ungar, Anne
- Keywords
- Danio rerio; frizzled7; frizzled7b; fz7; fz7b; forebrain; midbrain; hindbrain; ventral brain; ventromedial brain; neural tube; ventromedial neural tube; prechordal mesoderm; presomitic mesoderm; paraxial mesoderm
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Central Nervous System/metabolism
- Expressed Sequence Tags
- Gene Expression Regulation, Developmental*
- Humans
- Mesoderm/metabolism
- Molecular Sequence Data
- Neural Crest/embryology
- Phylogeny
- Prosencephalon/embryology
- RNA, Messenger/metabolism
- Receptors, Cell Surface/biosynthesis*
- Receptors, Cell Surface/genetics*
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Homology, Amino Acid
- Time Factors
- Tissue Distribution
- Zebrafish
- Zebrafish Proteins/biosynthesis*
- Zebrafish Proteins/genetics*
- PubMed
- 12351181 Full text @ Mech. Dev.
Citation
Ungar, A. and Calvey, C. (2002) Zebrafish frizzled7b is expressed in prechordal mesoderm, brain and paraxial mesoderm. Mechanisms of Development. 118(102):165-169.
Abstract
Frizzled (fz) genes encode receptors for the Wnt signaling pathway. We describe a novel fz gene, zebrafish fz7b. Maternal fz7b mRNA is detectable by RT-PCR. Embryonic fz7b is widely distributed in early epiboly stage embryos. By shield stage, expression appears enriched around the blastoderm margin. During epiboly, expression becomes restricted to the prechordal plate, presumptive midbrain and hindbrain and paraxial mesoderm. As somites form, labeling is briefly present in a segmental pattern. By mid-somitogensis, expression is particularly enriched in the forebrain, the forebrain-midbrain boundary, and the anterior hindbrain, but appears at lower levels throughout much of the rostral CNS. The CNS expression is at ventral and medial positions. The paraxial mesoderm expression becomes restricted to the tailbud. This pattern continues through 26 h. At 48 h, weak expression is seen in the pharyngeal arches and developing fin.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping