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Transcriptional signatures of liver regeneration upon cryoinjury. (A) Schematic representation of the experiment workflow. (B-D) Volcano plots representing the comparison of 1, 3 and 7 dpci with sham-operated adult zebrafish. DEGs: FC ≥1.5 (darker dots) or ≤−1.5 (lighter dots); P≤0.05; with top DEG annotated. (E) Bar plot representing the number of upregulated and downregulated DEGs at 1, 3 and 7 dpci. (F) Venn diagram representing DEGs at 1, 3 and 7 dpci. (G) GSEA of liver cell types during liver regeneration. (H) Dotplot representing the expression of key genes for specific liver cell populations upon cryoinjury.
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