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ZIRC
ZFIN ID: ZDB-GENE-010606-1
Gene Name: cadherin 1, type 1, E-cadherin (epithelial)
Gene Symbol: cdh1    Nomenclature History

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Previous Names: E-cadherin (1), hab, half baked

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including adherens junction maintenance; embryonic morphogenesis; and germ cell migration. Localizes to several cellular components, including the catenin complex; cell-cell adherens junction; and microvillus. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Is expressed in several structures, including axial mesoderm; blastoderm; germ ring; nervous system; and pronephros. Orthologous to several human genes including CDH1 (cadherin 1).
Genome Resources: Alliance (1),  Gene:114424 (1),  Ensembl(GRCz11):ENSDARG00000102750 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dtv43 Point Mutation Unknown Missense ENU
la011658Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • rk3 Point Mutation Intron 1 Splice Site, Premature Stop ENU
    sa41032 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm94 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ts18 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx230 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu44 Point Mutation Unknown Premature Stop
    xt17Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    xt18Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cdh1 2
    MO1-cdh1 N/A 1
    MO2-cdh1 N/A 3
    MO3-cdh1 N/A 23
    MO4-cdh1 N/A 9
    MO5-cdh1 N/A 1
    MO6-cdh1 N/A 3
    DISEASE ASSOCIATED WITH cdh1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    blepharocheilodontic syndrome 1 Alliance Blepharocheilodontic syndrome 1 119580
    breast cancer Alliance {Breast cancer, lobular} 114480
    endometrial cancer Alliance Endometrial carcinoma, somatic 608089
    ovarian cancer Alliance Ovarian cancer, somatic 167000
    prostate cancer Alliance {Prostate cancer, susceptibility to} 176807
    stomach cancer Alliance Gastric cancer, hereditary diffuse, with or without cleft lip and/or palate 137215
    DISEASE ASSOCIATED WITH cdh1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-cell adhesion (more)
    Cellular Component adherens junction (more)
    Molecular Function G-protein alpha-subunit binding (more)
    GO Terms (all 34)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdh1-201 (1)    Ensembl 2494
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pan-Cadherin polyclonal Rabbit IHC, WB Sigma-Aldrich
    24
    AB1-cdh1 polyclonal Rabbit IHC, WB 11
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdh1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:cdh1,cryaa:Cerulean) cryaaUAS cdh1Cerulean Danio rerio 1 2
    Tg(ubb:LOXP-EGFP-LOXP-cdh1-2A-Tomato) ubb 2Acdh1EGFPLOXPTomato Danio rerio 1 1
    tgbac(cdh1:cdh1-sfgfp,cryaa:cerulean) cdh1cryaa cdh1CeruleanGFP Danio rerio 1 2
    tgbac(cdh1:cdh1-tagbfp,cryaa:cerulean) cdh1cryaa cdh1CeruleanTagBFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    cdh1 Contained in: [BAC] CH73-289B2 (1) (order this), DKEY-173L11 (1) (order this)
    [Fosmid] CH1073-125P9 (1) (order this)
    cdh1 Encodes: [EST] eu736 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131820 (1) 3340 bp
    Genomic GenBank:BX322631 (1) 161710 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IFF8 (1) 877 aa
    Sequence Clusters UniGene:78411 (1)
    Sequence Information (all 21)
    ORTHOLOGY for cdh1 ( Chr: 7 )
    CITATIONS (127)