Gene
anxa4
- ID
- ZDB-GENE-030707-1
- Name
- annexin A4
- Symbol
- anxa4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; endoderm; hatching gland; mesenchymal cell; and pronephric duct. Orthologous to human ANXA4 (annexin A4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zhang et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-anxa4 | Zhang et al., 2014 | |
CRISPR2-anxa4 | Zhang et al., 2014 | |
CRISPR3-anxa4 | Zhang et al., 2014 | |
MO1-anxa4 | N/A | Zhang et al., 2014 |
MO2-anxa4 | N/A | Zhang et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Annexin | Annexin A4 | Annexin repeat | Annexin repeat, conserved site | Annexin superfamily |
---|---|---|---|---|---|---|
UniProtKB:Q804G7
|
321 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-271B8 | ZFIN Curated Data | |
Encodes | cDNA | MGC:64121 | ZFIN Curated Data | |
Encodes | cDNA | MGC:174455 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_181764 (1) | 1329 nt | ||
Genomic | GenBank:BX005297 (1) | 156906 nt | ||
Polypeptide | UniProtKB:Q804G7 (1) | 321 aa |
- Kolb, J., Tsata, V., John, N., Kim, K., Möckel, C., Rosso, G., Kurbel, V., Parmar, A., Sharma, G., Karandasheva, K., Abuhattum, S., Lyraki, O., Beck, T., Müller, P., Schlüßler, R., Frischknecht, R., Wehner, A., Krombholz, N., Steigenberger, B., Beis, D., Takeoka, A., Blümcke, I., Möllmert, S., Singh, K., Guck, J., Kobow, K., Wehner, D. (2023) Small leucine-rich proteoglycans inhibit CNS regeneration by modifying the structural and mechanical properties of the lesion environment. Nature communications. 14:68146814
- Ma, J., Yang, Z., Huang, Z., Li, L., Huang, J., Chen, J., Ni, R., Luo, L., He, J. (2023) Rngtt governs biliary-derived liver regeneration initiation by transcriptional regulation of mTORC1 and Dnmt1 in zebrafish. Hepatology (Baltimore, Md.). 78(1):167-178
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Oderberg, I.M., Goessling, W. (2023) Biliary epithelial cells are facultative liver stem cells during liver regeneration in adult zebrafish. JCI insight. 8(1):
- Zhang, Z., Yang, C., Wang, Z., Guo, L., Xu, Y., Gao, C., Sun, Y., Zhang, Z., Peng, J., Hu, M., Jan Lo, L., Ma, Z., Chen, J. (2023) Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis. Cell death discovery. 9:227227
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Brandt, Z.J., Echert, A.E., Bostrom, J.R., North, P.N., Link, B.A. (2020) Core Hippo pathway components act as a brake on Yap/Taz in the development and maintenance of the biliary network. Development (Cambridge, England). 147(12):
- Gu, W., Liu, S., Chen, L., Liu, Y., Gu, C., Ren, H.Q., Wu, B. (2020) Single-cell RNA sequencing reveals size-dependent effects of polystyrene microplastics on immune and secretory cell populations from zebrafish intestines. Environmental science & technology. 54(6):3417-3427
- Jung, K., Kim, M., So, J., Lee, S.H., Ko, S., Shin, D. (2020) Farnesoid X receptor activation impairs liver progenitor cell-mediated liver regeneration via the PTEN-PI3K-AKT-mTOR axis in zebrafish. Hepatology (Baltimore, Md.). 74(1):397-410
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