ZFIN ID: ZDB-GENE-000511-1
Gene Name: heart and neural crest derivatives expressed 2
Gene Symbol: hand2    Nomenclature History

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Previous Names: dhand (1), han, zdHAND (1), hands off, zgc:103415

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; determination of intestine left/right asymmetry; and nervous system development. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and pectoral fin. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2).
Genome Resources: Alliance (1),  Gene:58150 (1),  Ensembl(GRCz11):ENSDARG00000008305 (2)
GENE EXPRESSION
All Expression Data: 153 figures from 104 publications
Directly Submitted Expression Data: 6 figures (17 images) from Thisse et al., 2005 [eu107]
  6 figures (13 images) from Thisse et al., 2005 [eu880]
  6 figures (20 images) from Thisse et al., 2004 [IMAGE:7165464]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
c99 Insertion Unknown Unknown G_RAYS
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ch2Tg Transgenic Insertion 5' UTR Unknown DNA
    hand2_unspecified Unspecified Unknown Unknown
    s40 Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hand2
    2
    CRISPR2-hand2
    2
    MO1-hand2 N/A 1
    MO2-hand2 N/A 8
    DISEASE ASSOCIATED WITH hand2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hand2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hand2-201 (1)    Ensembl 1641
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hand2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actb2:LOXP-mCherry-STOP-LOXP-hand2) actb2 hand2LOXPmCherry Danio rerio 1 2
    Tg(cryaa:EGFP,hsp70l:hand2) cryaahsp70l EGFPhand2 Danio rerio 1 3
    Tg(fli1:hand2-2A-mCherry) fli1 2Ahand2mCherry Danio rerio 1 1
    Tg(hand2:GAL4-VP16) hand2 GAL4VP16 Danio rerio 1 4
    Tg(hand2:mCherry,myl7:EGFP) hand2myl7 EGFPmCherry Danio rerio 3 4
    Tg(hand2:TagRFP,myl7:EGFP) hand2myl7 EGFPTagRFP Danio rerio 4 2
    Tg(hsp70l:FLAG-hand2-2A-mCherry) hsp70l 2AFLAGhand2mCherry Danio rerio 1 4
    Tg(hsp70l:FLAG-hand2_103T>A_105S>A-2A-mCherry) hsp70l 2AFLAGhand2mCherryT2M Danio rerio 1 2
    Tg(hsp70l:FLAG-hand2_119F>P-2A-mCherry) hsp70l 2AFLAGhand2mCherry Danio rerio 1 2
    TgBAC(hand2:EGFP) hand2 EGFP Danio rerio 1 25
    MARKER RELATIONSHIPS
    hand2 Contained in: [BAC] CH211-15E22 (1)
    hand2 Encodes: [EST] eu107 (1), eu880 (1), IMAGE:7165464 (1)
    [cDNA] MGC:103415 (1), MGC:192190 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131626 (1) 1668 nt
    Genomic GenBank:BX000460 (1) 173084 nt
    Select Tool
    Polypeptide UniProtKB:P57102 (1) 208 aa
    Sequence Information (all 20)
    ORTHOLOGY for hand2 ( Chr: 1 )
    CITATIONS (231)