Gene
hand2
- ID
- ZDB-GENE-000511-1
- Name
- heart and neural crest derivatives expressed 2
- Symbol
- hand2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; epithelial cell differentiation; and heart development. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and pectoral fin. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 175 figures from 122 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu107 (17 images)
- eu880 (13 images)
- IMAGE:7165464 (20 images)
Wild Type Expression Summary
- All Phenotype Data
- 17 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| c99 | Allele with one insertion | Unknown | Unknown | g-rays | |
| ch2Tg | Transgenic insertion | 5' UTR | Unknown | DNA | |
| hand2_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| s40 | unknown | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-hand2 | (2) | |
| CRISPR2-hand2 | (2) | |
| CRISPR3-hand2 | Saunders et al., 2023 | |
| CRISPR4-hand2 | Saunders et al., 2023 | |
| CRISPR5-hand2 | Saunders et al., 2023 | |
| MO1-hand2 | N/A | Sun et al., 2007 |
| MO2-hand2 | N/A | (10) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|---|
| UniProtKB:A2BDM6 | InterPro | 205 | |||
| UniProtKB:P57102 | InterPro | 208 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(hand2:EGFP) |
|
| 1 | (34) | |
| Tg(actb2:LOXP-mCherry-STOP-LOXP-hand2) |
| 1 | (2) | ||
| Tg(cryaa:EGFP,hsp70l:hand2) |
|
| 1 | (3) | |
| Tg(fli1:hand2-2A-mCherry) |
| 1 | Palencia-Desai et al., 2015 | ||
| Tg(hand2:GAL4-VP16) |
|
| 1 | (4) | |
| Tg(hand2:mCherry,myl7:EGFP) |
|
| 3 | (4) | |
| Tg(hand2:TagRFP,myl7:EGFP) |
|
| 4 | (2) | |
| Tg(hsp70l:FLAG-hand2-2A-mCherry) |
| 1 | (4) | ||
| Tg(hsp70l:FLAG-hand2_103T>A_105S>A-2A-mCherry) |
| 1 | (2) | ||
| Tg(hsp70l:FLAG-hand2_119F>P-2A-mCherry) |
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-15E22 | ZFIN Curated Data | |
| Encodes | EST | eu107 | Thisse et al., 2005 | |
| Encodes | EST | eu880 | Thisse et al., 2005 | |
| Encodes | EST | IMAGE:7165464 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:103415 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192190 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131626 (1) | 1641 nt | ||
| Genomic | GenBank:BX000460 (2) | 173084 nt | ||
| Polypeptide | UniProtKB:P57102 (1) | 208 aa |
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Liang, S., Zhou, Y., Chang, Y., Li, J., Zhang, M., Gao, P., Li, Q., Yu, H., Kawakami, K., Ma, J., Zhang, R. (2024) A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration. Cellular and molecular life sciences : CMLS. 81:158158
- Miller, B.M., Goessling, W. (2024) The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis. JCI insight. 9(16):
- Truong, B.T., Shull, L.C., Zepeda, B.J., Lencer, E., Artinger, K.B. (2024) Human split hand/foot variants are not as functional as wildtype human PRDM1 in the rescue of craniofacial defects. Birth defects research. 116:e2327e2327
- Uribe-Montes, L.C., Sanabria-Camargo, C.A., Piñeros-Romero, C.C., Otálora-Tarazona, S., Ávila-Jiménez, E., Acosta-Virgüez, E., Garavito-Aguilar, Z.V. (2024) Fibronectin and Hand2 influence tubulogenesis during pronephros development and mesonephros regeneration in zebrafish (Danio rerio). PLoS One. 19:e0307390e0307390
- Yu, C., Li, X., Ma, J., Liang, S., Zhao, Y., Li, Q., Zhang, R. (2024) Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration. Cellular and molecular life sciences : CMLS. 81:6060
- Zhao, Y., Lv, H., Yu, C., Liang, J., Yu, H., Du, Z., Zhang, R. (2024) Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration. Biochimica et biophysica acta. Molecular basis of disease. 1870(7):167442
- Li, X., Zeng, L., Qu, Z., Zhang, F. (2023) Huoxin pill protects verapamil-induced zebrafish heart failure through inhibition of oxidative stress-triggered inflammation and apoptosis. Heliyon. 10:e23402e23402
- Oderberg, I.M., Goessling, W. (2023) Biliary epithelial cells are facultative liver stem cells during liver regeneration in adult zebrafish. JCI insight. 8(1):
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
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