ZFIN ID: ZDB-GENE-010522-1
Gene Name: ceruloplasmin
Gene Symbol: cp    Nomenclature History

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Previous Names: cer (1), wu:fi23f10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have ferroxidase activity. Predicted to be involved in iron ion homeostasis and iron ion transport. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Is expressed in digestive system; female organism; liver and biliary system; male organism; and yolk syncytial layer. Orthologous to human CP (ceruloplasmin).
Genome Resources: Alliance (1),  Gene:84702 (1),  Ensembl(GRCz11):ENSDARG00000010312 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa30734 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cp N/A 1
    DISEASE ASSOCIATED WITH cp HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    aceruloplasminemia Alliance Cerebellar ataxia 604290
    Hemosiderosis, systemic, due to aceruloplasminemia 604290
    [Hypoceruloplasminemia, hereditary] 604290
    DISEASE ASSOCIATED WITH cp VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular iron ion homeostasis (more)
    Cellular Component cytoplasm (more)
    Molecular Function copper ion binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR002355 Multicopper oxidase, copper-binding site
    Homologous_superfamily IPR008972 Cupredoxin
    Domain IPR011706 Multicopper oxidase, type 2
    Domain IPR011707 Multicopper oxidase, type 3
    Family IPR027150 Ceruloplasmin
    Conserved_site IPR033138 Multicopper oxidases, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cp-201 (1)    Ensembl 3590
    cp-202 (1)    Ensembl 619
    cp-203 (1)    Ensembl 620
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cp polyclonal Rabbit WB AnaSpec
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cp No data available
    MARKER RELATIONSHIPS
    cp Contained in: [BAC] CH211-284E20 (1)
    cp Contains: [STS] chunp40190
    cp Encodes: [EST] fi23f10 (1)
    [cDNA] MGC:55445 (1), MGC:77935 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131802 (1) 3370 bp
    Genomic GenBank:AL954145 (1) 160871 bp
    Select Tool
    Polypeptide UniProtKB:Q6P3G1 (1) 1087 aa
    Sequence Information (all 21)
    ORTHOLOGY for cp ( Chr: 22 )
    CITATIONS (107)