Gene

il6st

ID

ZDB-GENE-080104-6

Name

interleukin 6 cytokine family signal transduce

Symbol

il6st Nomenclature History

Previous Names

gp130 (1)
sb:eu844

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within positive regulation of axon regeneration. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including epidermis; immune system; liver; muscle; and sensory system. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and immunodeficiency 94. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 11 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu844 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il6st Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hyper IgE recurrent infection syndrome 4	Alliance	Hyper-IgE syndrome 4B, autosomal recessive, with recurrent infections	618523
immunodeficiency 94	Alliance	?Immunodeficiency 94 with autoinflammation and dysmorphic facies	619750
		Hyper-IgE syndrome 4A, autosomal dominant, with recurrent infections	619752
		Stuve-Wiedemann syndrome 2	619751

Associated With il6st Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Family	IPR052672	Type I Cytokine Receptor Family, Type 2 Subfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily