Gene

il6st

ID

ZDB-GENE-080104-6

Name

interleukin 6 cytokine family signal transduce

Symbol

il6st Nomenclature History

Previous Names

gp130 (1)
sb:eu844

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Is predicted to enable cytokine binding activity and cytokine receptor activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within positive regulation of axon regeneration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Is expressed in several structures, including epidermis; immune system; liver; muscle; and sensory system. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary localized cutaneous amyloidosis 2. Orthologous to several human genes including IL6ST (interleukin 6 cytokine family signal transducer).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu844 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il6st Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hyper IgE recurrent infection syndrome 4	Alliance	Hyper-IgE recurrent infection syndrome 4B, autosomal recessive	618523
		Hyper-IgE recurrent infection syndrome 4A, autosomal dominant	619752
		Stuve-Wiedemann syndrome 2	619751
		?Immunodeficiency 94 with autoinflammation and dysmorphic facies	619750

Associated With il6st Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003961	Fibronectin type III
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like fold
UniProtKB:C0SPC4 InterPro	859
UniProtKB:A8WH79 InterPro	866
UniProtKB:F1RCZ2 InterPro	859

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	il6st-201 (1) Ensembl	2601 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	il6st-202 (1) Ensembl	8300 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations