Gene
dll4
- ID
- ZDB-GENE-041014-73
- Name
- delta-like 4 (Drosophila)
- Symbol
- dll4 Nomenclature History
- Previous Names
-
- si:ch211-244p18.5
- zgc:136596
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable Notch binding activity. Involved in negative regulation of sprouting angiogenesis and negative regulation of vascular endothelial cell proliferation. Acts upstream of or within several processes, including negative regulation of blood vessel endothelial cell migration; vasculature development; and ventral spinal cord interneuron differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including atrioventricular canal endocardium; brain; caudal hematopoietic tissue; vasculature; and xanthophore. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 67 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 26 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| dmh20 | Allele with one point mutation | Unknown | Nonsynonymous | ENU | |
| dmh32 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| dmh33 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| dmh34 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| j16e1 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa9436 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37051 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| uq10bh | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dll4 | Weijts et al., 2018 | |
| CRISPR2-dll4 | Savage et al., 2019 | |
| CRISPR3-dll4 | Sahu et al., 2021 | |
| CRISPR4-dll4 | Sahu et al., 2021 | |
| MO1-dll4 | N/A | (11) |
| MO2-dll4 | N/A | (12) |
| MO3-dll4 | N/A | (12) |
| MO4-dll4 | N/A | (12) |
| MO5-dll4 | N/A | (4) |
| MO6-dll4 | N/A | Biyashev et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Adams-Oliver syndrome 6 | 616589 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain | Notch signaling pathway |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1ECY3
|
683 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC2(dll4:GAL4FF) |
|
| 1 | (2) | |
| TgBAC(dll4:GAL4FF) |
|
| 1 | (5) | |
| Tg(dll4:GAL4) |
|
| 1 | (2) | |
| Tg(hsp70l:dll4-2A-GFP) |
| 1 | Sahu et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-244P18 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-14A13 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136596 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079835 (1) | 3039 nt | ||
| Genomic | GenBank:AL929049 (2) | 223182 nt | ||
| Polypeptide | UniProtKB:Q1ECY3 (1) | 683 aa |
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Heng, J., Shi, B., Zhou, J.Y., Zhang, Y., Ma, D., Yang, Y.G., Liu, F. (2023) Cpeb1b-mediated cytoplasmic polyadenylation of shha mRNA modulates zebrafish definitive hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 120:e2212212120e2212212120
- Zhou, L., Zhang, W., Xiang, Y., Qian, Z., Zhou, J., Ni, L., Feng, Y., Gao, B. (2023) The apatinib and pemetrexed combination has antitumor and antiangiogenic effects against NSCLC. Open life sciences. 18:2022053320220533
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- Gurung, S., Restrepo, N.K., Chestnut, B., Klimkaite, L., Sumanas, S. (2022) Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos. Scientific Reports. 12:13065
- Kraus, J.M., Giovannone, D., Rydzik, R., Balsbaugh, J.L., Moss, I.L., Schwedler, J.L., Bertrand, J.Y., Traver, D., Hankenson, K.D., Crump, J.G., Youngstrom, D.W. (2022) Notch signaling enhances bone regeneration in the zebrafish mandible. Development (Cambridge, England). 149(5)
- Kugler, E.C., Frost, J., Silva, V., Plant, K., Chhabria, K., Chico, T.J.A., Armitage, P.A. (2022) Zebrafish Vascular Quantification (ZVQ): a tool for quantification of three-dimensional zebrafish cerebrovascular architecture by automated image analysis. Development (Cambridge, England). 149(3):
- Lange, M., Ohnesorge, N., Hoffmann, D., Rocha, S.F., Benedito, R., Siekmann, A.F. (2022) Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling. Developmental Biology. 486:26-43
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