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ZIRC
ZFIN ID: ZDB-GENE-041014-73
Gene Name: delta-like 4 (Drosophila)
Gene Symbol: dll4    Nomenclature History

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Previous Names: si:ch211-244p18.5, zgc:136596

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have Notch binding activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; regulation of vascular endothelial growth factor receptor signaling pathway; and vasculature development. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Is expressed in several structures, including atrioventricular canal endocardium; otic vesicle; pronephric duct; vasculature; and xanthophore. Orthologous to human DLL4 (delta like canonical Notch ligand 4).
Genome Resources: Alliance (1),  Gene:563920 (1),  Ensembl(GRCz11):ENSDARG00000070425 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dmh20 Point Mutation Unknown Nonsynonymous ENU
dmh32 Point Mutation Unknown Premature Stop ENU
dmh33 Point Mutation Unknown Premature Stop ENU
dmh34 Point Mutation Unknown Premature Stop ENU
j16e1 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9436 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37051 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • uq10bh Small Deletion Unknown Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dll4
    1
    CRISPR2-dll4
    1
    MO1-dll4 N/A 10
    MO2-dll4 N/A 10
    MO3-dll4 N/A 11
    MO4-dll4 N/A 7
    MO5-dll4 N/A 2
    MO6-dll4 N/A 1
    MO7-dll4 N/A 1
    TALEN1-dll4 1
    DISEASE ASSOCIATED WITH dll4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Adams-Oliver syndrome 6 616589
    DISEASE ASSOCIATED WITH dll4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 26)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dll4-201 (1)    Ensembl 3170
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dll4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(dll4:GAL4FF) dll4 GAL4FF Danio rerio 1 5
    TgBAC2(dll4:GAL4FF) dll4 GAL4FF Danio rerio 1 2
    MARKER RELATIONSHIPS
    dll4 Contained in: [BAC] CH211-244P18 (1) (order this), DKEY-14A13 (1) (order this)
    dll4 Encodes: [cDNA] MGC:136596 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001079835 (1) 3039 bp
    Genomic GenBank:AL929049 (1) 223182 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q7E4 (1) 690 aa
    Sequence Clusters UniGene:83136 (1)
    Sequence Information (all 15)
    ORTHOLOGY for dll4 ( Chr: 20 )
    CITATIONS (147)