| ZFIN ID: ZDB-GENE-000705-1 |
| Gene Name: | kinase insert domain receptor like | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | kdrl Nomenclature History |
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Attributions
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| Previous Names: | kdr, kdra (1), fetal liver kinase, flk-1, flk1 (1), flk, flt1b (1), VEGFR-2 (1), vegfr2, vegfr2a (1), vegfr4, vegr2, wu:fk52c05 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 14 Mapping Details/Browsers | |||||||||||||
| Description: | Exhibits protein tyrosine kinase activity. Involved in circulatory system development and thyroid gland development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including cardiovascular system; head; hematopoietic system; mesoderm; and pleuroperitoneal region. | |||||||||||||
| Genome Resources: | Alliance (1), Gene:796537 (1), Ensembl(GRCz11):ENSDARG00000105215 (1) | |||||||||||||
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| hu5088 | Point Mutation | Unknown | Unknown | ENU | |
| ihb123 | Small Deletion | Unknown | Unknown | CRISPR |
|
| ion38Tg | Transgenic Insertion | Intron 29 | Unknown | DNA_AND_CRISPR | |
| la010852Tg | Transgenic Insertion | Unknown | Unknown | DNA |
|
| la018984Tg | Transgenic Insertion | Unknown | Unknown | DNA | |
| la027548Tg | Transgenic Insertion | Unknown | Unknown | DNA | |
| sa9469 | Point Mutation | Unknown | Splice Site | ENU |
|
| sa15912 | Point Mutation | Unknown | Premature Stop | ENU |
|
| sa19086 | Point Mutation | Unknown | Splice Site | ENU | |
| sa28333 | Point Mutation | Unknown | Premature Stop | ENU | |
| sa44810 | Point Mutation | Unknown | Unknown | ENU |
|
| sa44811 | Point Mutation | Unknown | Unknown | ENU |
|
| sa45520 | Point Mutation | Unknown | Premature Stop | ENU |
|
| t20257 | Point Mutation | Unknown | Premature Stop | ENU |
|
| t21588 | Point Mutation | Unknown | Premature Stop | ENU |
|
| um6 | Point Mutation | Unknown | Missense | ENU | |
| um19 | Small Deletion | Exon 2 | Frameshift | ZINC_FINGER_NUCLEASE | |
| y17 | Point Mutation | Unknown | Missense | ENU |
PHENOTYPE
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | angiogenesis (more) |
| Cellular Component | integral component of membrane (more) |
| Molecular Function | protein tyrosine kinase activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
kdrl-201
(1)
|
5790 |
Select Tool
|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
ANTIBODIES
| Name | Type | Isotype | Host Organism | Assay | Source | Publications |
|---|---|---|---|---|---|---|
| Ab2-kdrl | polyclonal | Rabbit |
Kerafast
|
2 | ||
| Ab1-kdrl | polyclonal | IgG | Rabbit | IHC |
Thermo Fisher Scientific (Lab Vision)
|
2 |
PLASMIDS
| Addgene:36 p flk1 |
| Addgene:p5E-kdrl |
CONSTRUCTS WITH SEQUENCES FROM kdrl
MARKER RELATIONSHIPS
| kdrl Contained in: | [BAC] CH211-231B5 (1), CH211-276G21 (1), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this) |
| kdrl Encodes: |
[EST]
cssl:d0146 (1),
fk52c05
[cDNA] MGC:158203 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_131472 (1) | 3906 nt |
Select Tool
|
| Genomic | GenBank:CR759732 (1) | 225630 nt | Blast at MegaBLAST |
| Polypeptide | UniProtKB:Q8AXB3 (1) | 1302 aa |
Select Tool
|
ORTHOLOGY for kdrl (
Chr:
14
)
CITATIONS (562)