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ZIRC
ZFIN ID: ZDB-GENE-000705-1
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Gene Name: kinase insert domain receptor like
Gene Symbol: kdrl
Sequence Ontology ID : SO:0001217

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Previous Names: kdr, kdra (1), fetal liver kinase, flk-1, flk1 (1), flk, flt1b (1), VEGFR-2 (1), vegfr2, vegfr2a (1), vegfr4, vegr2, wu:fk52c05

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(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits protein tyrosine kinase activity. Involved in circulatory system development and thyroid gland development. Predicted to localize to the integral component of plasma membrane and receptor  ...
GENE EXPRESSION
All Expression Data: 283 figures from 209 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2008 [cssl:d0146]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu5088 Point Mutation Unknown Unknown ENU
ihb123 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • ion38Tg Transgenic Insertion Intron 29 Unknown DNA_AND_CRISPR
    la010852Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la018984Tg Transgenic Insertion Unknown Unknown DNA
    la027548Tg Transgenic Insertion Unknown Unknown DNA
    sa9469 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa15912 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa19086 Point Mutation Unknown Splice Site ENU
    sa28333 Point Mutation Unknown Premature Stop ENU
    sa44810 Point Mutation Unknown Unknown ENU
    sa44811 Point Mutation Unknown Unknown ENU
    sa45520 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • t20257 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • t21588 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • um6 Point Mutation Unknown Missense ENU
    um19 Small Deletion Exon 2 Frameshift ZINC_FINGER_NUCLEASE
    y17 Point Mutation Unknown Missense ENU
    Targeting reagents:
    PHENOTYPE
    Data: 19 figures from 13 publications
    Observed in:
    DISEASE ASSOCIATED WITH kdrl HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH kdrl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein tyrosine kinase activity (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013151 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR036179 (1)
  • InterPro:IPR041348 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF00047 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF17988 (1)
  • EC:2.7.10.1 (1)
    • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA kdrl-201 (1) 5790
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM kdrl
    MARKER RELATIONSHIPS
    kdrl Contained in: [BAC] CH211-231B5 (1) (order this), CH211-276G21 (1) (order this), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
    kdrl Encodes: [EST] cssl:d0146 (1) (order this), fk52c05
    [cDNA] MGC:158203 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131472 (1) 3906 bp
    Select Tool
    Genomic GenBank:CR759732 (1) 225630 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8AXB3 (1) 1302 aa
    Select Tool
    Sequence Clusters UniGene:75094 (1)
    Sequence Information (all 39)
    OTHER kdrl GENE PAGES
  • Alliance (1)
  • Gene:796537 (1)
  • VEGA:OTTDARG00000031823 (1)
  • Ensembl(GRCz11):ENSDARG00000105215 (1)
    • ORTHOLOGY for kdrl ( Chr: 14 )
    CITATIONS (537)