FIGURE

Fig. 5

ID

ZDB-FIG-140617-18

Publication

Flasse et al., 2013 - Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish

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Fig. 5

Impaired endocrine cell differentiation in neurod1 morphants. Ventral views with anterior to the left of WISH showing expression of insulin(A-C), somatostatin(D-F), ghrelin(G-I) and glucagon(J-L) in control (A, D, G, J), Mo1-neurod1(B, E, H, K) and Mo2-neurod1(C, F, I, L) morphants at 30 hpf. The quantifications on the right side of the figure represent the number of positive cells per embryo for controls and neurod1 morphants. Asterisks (***) indicate that the difference between cell number in controls and neurod1 morphants is statistically significant by Student’s t-test (P <0.001). Scale bars : 50 µm hpf, hours post fertilization; WISH, whole-mount in situ hybridization.

Expression Data

Genes:	gcga ghrl ins sst2
Fish:	WT WT + MO2-neurod1 WT + MO3-neurod1
Knockdown Reagents:	MO2-neurod1 MO3-neurod1
Anatomical Term:	pancreatic bud
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-neurod1 WT + MO3-neurod1
Knockdown Reagents:	MO2-neurod1 MO3-neurod1
Observed In:	endocrine pancreas development
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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