Gene
ghrl
- ID
- ZDB-GENE-070622-2
- Name
- ghrelin/obestatin prepropeptide
- Symbol
- ghrl Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable growth hormone-releasing hormone activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of response to food; and response to food. Predicted to be located in extracellular region. Is expressed in several structures, including diencephalon; digestive system; endocrine system; heart; and immune system. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ghrl | Blanco et al., 2019 | |
| CRISPR2-ghrl | Shi et al., 2021 | |
| CRISPR3-ghrl | Shi et al., 2021 | |
| MO1-ghrl | N/A | Li et al., 2009 |
| MO2-ghrl | N/A | Li et al., 2009 |
| TALEN1-ghrl | Shi et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Motilin/ghrelin-associated peptide | Preproghrelin peptide |
|---|---|---|---|---|
| UniProtKB:Q3ZV42 | InterPro | 104 | ||
| UniProtKB:F1QKX9 | InterPro | 104 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-ghrl | monoclonal | Mouse |
|
Phoenix Pharmaceuticals, Inc.
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-28N18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083872 (1) | 472 nt | ||
| Genomic | GenBank:BX936393 (1) | 204873 nt | ||
| Polypeptide | UniProtKB:F1QKX9 (1) | 104 aa |
- Fei, Y., Bao, Z., Wang, Q., Zhu, Y., Lu, J., Ouyang, L., Hu, Q., Zhou, Y., Chen, L. (2024) CRISPR/Cas9-induced LEAP2 and GHSR1a knockout mutant zebrafish displayed abnormal growth and impaired lipid metabolism. General and comparative endocrinology. 355:114563
- Guan, K., Shan, C., Guo, A., Gao, X., Li, X. (2023) Ghrelin regulates hyperactivity-like behaviors via growth hormone signaling pathway in zebrafish (Danio rerio). Frontiers in endocrinology. 14:11632631163263
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- de Alba, G., Carrillo, S., Sánchez-Vázquez, F.J., López-Olmeda, J.F. (2022) Combined blue light and daily thermocycles enhance zebrafish growth and development. Journal of experimental zoology. Part A, Ecological and integrative physiology. 337(5):501-515
- Reuter, A.S., Stern, D., Bernard, A., Goossens, C., Lavergne, A., Flasse, L., Von Berg, V., Manfroid, I., Peers, B., Voz, M.L. (2022) Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. PLoS Genetics. 18:e1010109
- Athapaththu, A.M.G.K., Molagoda, I.M.N., Jayasooriya, R.G.P.T., Choi, Y.H., Jeon, Y.J., Park, J.H., Lee, B.J., Kim, G.Y. (2021) Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABAA and GABAB Receptors. International Journal of Molecular Sciences. 22(20):
- Hsieh, Y.W., Tsai, Y.W., Lai, H.H., Lai, C.Y., Lin, C.Y., Her, G.M. (2021) Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish. Biomedicines. 9(8):
- Montalbano, G., Maugeri, A., Guerrera, M.C., Miceli, N., Navarra, M., Barreca, D., Cirmi, S., Germanà, A. (2021) A White Grape Juice Extract Reduces Fat Accumulation through the Modulation of Ghrelin and Leptin Expression in an In Vivo Model of Overfed Zebrafish. Molecules. 26(4):
- Schneider, A.C.R., de Moura, A.C., Carvalho, F.B., Alves, T., Meurer, F., Porawski, M., da Silveira, T.R. (2021) Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose. Zebrafish. 18(3):184-189
- Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X., Wang, S., Xu, S., Zheng, M., Huang, J., Wan, X., Guan, W., Su, K.P., Ye, M., Gao, X., Yin, Z., Li, X. (2021) Ghrelin Modulates Dopaminergic Neuron Formation and Attention Deficit Hyperactivity Disorder-like Behaviors: From Animals to Human Models. Brain, behavior, and immunity. 94:327-337
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