ZFIN ID: ZDB-GENE-070622-2
Gene Name: ghrelin/obestatin prepropeptide
Gene Symbol: ghrl    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have growth hormone-releasing hormone activity. Involved in several processes, including chordate embryonic development; regulation of response to food; and response to food. Predicted to localize to extracellular region. Is expressed in several structures, including diencephalon; digestive system; ghrelin secreting cell; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in diabetic neuropathy; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide).
Genome Resources: Alliance (1),  Gene:798613 (1),  Ensembl(GRCz11):ENSDARG00000054239 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ghrl
1
MO1-ghrl N/A 1
MO2-ghrl N/A 1
DISEASE ASSOCIATED WITH ghrl HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
obesity Alliance {Obesity, susceptibility to} 601665
DISEASE ASSOCIATED WITH ghrl VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of response to food (more)
Cellular Component extracellular region (more)
Molecular Function growth hormone-releasing hormone activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ghrl-201 (1)    Ensembl 599
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab2-ghrl monoclonal Mouse IHC Phoenix Pharmaceuticals, Inc.
1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ghrl No data available
MARKER RELATIONSHIPS
ghrl Contained in: [BAC] DKEY-28N18 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001083872 (1) 472 nt
Genomic GenBank:BX936393 (1) 204873 nt Blast at MegaBLAST
Polypeptide UniProtKB:D0EW40 (1) 104 aa
Sequence Information (all 18)
ORTHOLOGY for ghrl ( Chr: 6 )
CITATIONS (56)