ZFIN ID: ZDB-GENE-010219-1
Gene Name: glucagon a
Gene Symbol: gcga    Nomenclature History

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Previous Names: gcg (1), GLP-1 (1), glu, zgc:103616

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Exhibits glucagon receptor binding activity. Involved in response to starvation and type B pancreatic cell development. Predicted to localize to extracellular region. Is expressed in digestive system; endocrine system; and endoderm. Human ortholog(s) of this gene implicated in Alzheimer's disease and prediabetes syndrome. Orthologous to human GCG (glucagon).
Genome Resources: Alliance (1),  Gene:494052 (1),  Ensembl(GRCz11):ENSDARG00000079296 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa43786 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gcga N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gcga HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gcga VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to starvation (more)
    Cellular Component extracellular region (more)
    Molecular Function glucagon receptor binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gcga-201 (1)    Ensembl 1766
    gcga-202 (1)    Ensembl 820
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gcga
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(gcga:Cre,cryaa:Venus) cryaagcga CreVenus Danio rerio 1 5
    Tg(gcga:GFP) gcga GFP Danio rerio 1 32
    MARKER RELATIONSHIPS
    gcga Contained in: [BAC] CH73-2D23 (1)
    [Fosmid] CH1073-467M9 (1)
    gcga Encodes: [cDNA] MGC:103616 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001008595 (1) 1781 nt
    Genomic GenBank:CU570889 (1) 52554 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IS85 (1) 176 aa
    Sequence Information (all 17)
    ORTHOLOGY for gcga ( Chr: 22 )
    CITATIONS (95)