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Gene

ins

ID
ZDB-GENE-980526-110
Name
preproinsulin
Symbol
ins Nomenclature History
Previous Names
  • insa (1)
  • zgc:109842
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable hormone activity. Acts upstream of or within several processes, including negative regulation of feeding behavior; positive regulation of pancreatic A cell differentiation; and type B pancreatic cell differentiation. Predicted to be located in extracellular region. Is expressed in several structures, including blood plasma; dermal bone; digestive system; endocrine cell; and endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
312 figures from 184 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ins Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 10 Alliance Maturity-onset diabetes of the young, type 10 613370
type 1 diabetes mellitus 2 Alliance Diabetes mellitus, insulin-dependent, 2 125852
Diabetes mellitus, permanent neonatal 4 618858
Hyperproinsulinemia 616214
Associated With ins Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022353 Insulin, conserved site
Domain IPR016179 Insulin-like
Family IPR004825 Insulin
Family IPR022352 Insulin family
Homologous_superfamily IPR036438 Insulin-like superfamily
Domain Details Per Protein
Protein Length Insulin Insulin, conserved site Insulin family Insulin-like Insulin-like superfamily
UniProtKB:Q9DDE5 108
UniProtKB:B2GSI0 108
UniProtKB:O73727 108
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-ins polyclonal Guinea pig
  • IHC
Biomeda Corporation
7
Ab6-ins polyclonal Guinea pig
  • IHC
Abcam plc
2
Ab1-ins polyclonal Guinea pig
  • IHC
Dako North America, Inc.
29
Ab3-ins polyclonal Guinea pig
  • IHC
Millipore
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations