ZFIN ID: ZDB-FIG-080214-4
Dal-Pra et al., 2006 - Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Developmental Biology   298(2):514-526 Full text @ Dev. Biol.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage: 50%-epiboly
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Unknown

Fig. 1 Comparative analysis of ventralization phenotypes. Homozygous mutant embryos for chordin (din/din, panel A), ogon (ogo/ogo, panel B) as well as chd morphants in ogon mutant background (C) display ventralization phenotypes similar to those obtained after injection of low amount of bmp2b RNA (1 pg, panel D). Injection of 5 pg bmp2b RNA (E) results in stronger ventralization with complete loss of head while injection of 20 pg RNA (F) completely abolishes the D/V patterning and embryos appear radialized. At the onset of gastrulation, ogo transcripts (G) are observed in the ventral part of the embryo while chd (H) is expressed in a broad dorsal domain, which includes the nog1 expression territory (I). Embryos are in lateral view, anterior to the left (A–F) or anterior to the top (G–I).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
chrd WT standard conditions 50%-epiboly whole organism dorsal side ISH
nog1 WT standard conditions 50%-epiboly whole organism dorsal side ISH
szl WT standard conditions 50%-epiboly whole organism ventral side ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
Df(Chr25:szl)m60/m60(HK) standard conditions Unknown whole organism wholly ventralized, abnormal
Df(Chr25:szl)m60/m60 + MO1-chrd(HK) standard conditions Unknown whole organism wholly ventralized, abnormal
chrdtm84/tm84 standard conditions Unknown whole organism wholly ventralized, abnormal
Acknowledgments:
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Reprinted from Developmental Biology, 298(2), Dal-Pra, S., Fürthauer, M., Van-Celst, J., Thisse, B., and Thisse, C., Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity, 514-526, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.