ZFIN ID: ZDB-GENE-991206-8
Gene Name: noggin 1
Gene Symbol: nog1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: zNog1, fc23h06, wu:fc23h06 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Involved in dorsal/ventral pattern formation; negative regulation of BMP signaling pathway; and negative regulation of endodermal cell fate specification. Localizes to Golgi apparatus and synapse. Is expressed in several structures, including central nervous system; mesoderm; neural tube; optic vesicle; and presumptive shield. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism. Orthologous to human NOG (noggin).
Genome Resources: Alliance (1),  Gene:30174 (1),  Ensembl(GRCz11):ENSDARG00000058819 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nog1 N/A 5
MO2-nog1 N/A 1
DISEASE ASSOCIATED WITH nog1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type B2 Alliance Brachydactyly, type B2 611377
multiple synostoses syndrome Alliance Multiple synostoses syndrome 1 186500
proximal symphalangism Alliance Symphalangism, proximal, 1A 185800
tarsal-carpal coalition syndrome Alliance Tarsal-carpal coalition syndrome 186570
Stapes ankylosis with broad thumbs and toes 184460
DISEASE ASSOCIATED WITH nog1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process dorsal/ventral pattern formation (more)
Cellular Component Golgi apparatus (more)
Molecular Function molecular_function (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nog1-201 (1)    Ensembl 2143
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nog1 No data available
MARKER RELATIONSHIPS
nog1 Contained in: [BAC] CH211-253B18 (1)
nog1 Encodes: [EST] fc23h06 (1)
[cDNA] MGC:85601 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_130983 (1) 2188 nt
Genomic GenBank:BX539325 (1) 183783 nt
Select Tool
Polypeptide UniProtKB:Q6NV45 (1) 216 aa
Sequence Information (all 14)
ORTHOLOGY for nog1 ( Chr: 3 )
CITATIONS (68)