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ZFIN ID: ZDB-FIG-080214-6
Dal-Pra et al., 2006 - Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Developmental Biology   298(2):514-526 Full text @ Dev. Biol.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Prim-15

Fig. 3 Inactivation of noggin1 enhances the ventralization phenotype of chordin loss of function. (A) MO-chd-injected embryos at 30 hpf. (B–F) Injection of MO-chd together with MO-nog1 leads to (B) class 1 (C1) embryos corresponding to a weak enhancement of chd phenotype. In class 2 (C2) embryos, the ventralization phenotype following (C) injection of MO-chd and MO-nog1 or (D) injection of MO-nog1 in chordino (din/din) mutant is more pronounced than in class 1, with loss of most of the head territory. (E, F) In class 3 (C3) embryos, the ventralization after double chd-nog1 MO injection is stronger with an almost complete disappearance of anterior and dorsal territories. Lateral views, anterior to the left.

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-chrd standard conditions Prim-15 whole organism wholly ventralized, abnormal
WT + MO1-chrd + MO1-nog1 standard conditions Prim-15 head anterior region agenesis, abnormal
Prim-15 head anterior region truncated, abnormal
Prim-15 whole organism wholly ventralized, abnormal
chrdtm84/tm84 + MO1-nog1 standard conditions Prim-15 head agenesis, abnormal
Prim-15 whole organism wholly ventralized, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 298(2), Dal-Pra, S., Fürthauer, M., Van-Celst, J., Thisse, B., and Thisse, C., Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity, 514-526, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.