ZFIN Morpholino: MO1-irf8

Target Location

Genome Build: GRCz11Chromosome: 18

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-irf8

No data available

Phenotype

Phenotype resulting from MO1-irf8

Phenotype	Fish	Figures
defense response to fungus process quality, abnormal	WT + MO1-irf8	Fig. 5 from Knox et al., 2014
macrophage absent, abnormal	WT + MO1-irf8	Fig. 2 from Li et al., 2011
macrophage aplastic, abnormal	uwm12Tg + MO1-irf8	Fig. S2 from Knox et al., 2014
macrophage decreased amount, abnormal	uwm12Tg + MO1-irf8	Fig. 5 from Pagán et al., 2015 Fig. S1 from Yan et al., 2015 Fig. S2 from Knox et al., 2014 Fig. S4 from Feng et al., 2012 Fig. 2 from Li et al., 2011
microglial cell decreased amount, abnormal	WT + MO1-irf8	Fig. 2 from Li et al., 2011

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Phenotype of all Fish created by or utilizing MO1-irf8

Phenotype	Fish	Conditions	Figures
whole organism decreased life span, exacerbated	AB + MO1-irf8	bacterial treatment by injection: Streptococcus iniae	Fig. 5 from Vincent et al., 2017
whole organism decreased life span, exacerbated	AB/TL + MO1-irf8	bacterial treatment by injection: Salmonella enterica subsp. enterica serovar Typhimurium	Fig. 4 from Masud et al., 2019
whole organism has extra parts of type neutrophil, abnormal	TU + MO1-irf8	bacterial treatment by injection: Acinetobacter baumannii ATCC 17978	Fig. S2 from Bhuiyan et al., 2016
whole organism has fewer parts of type macrophage, abnormal	TU + MO1-irf8	bacterial treatment by injection: Acinetobacter baumannii ATCC 17978	Fig. S2 from Bhuiyan et al., 2016
head epidermis irg1l expression position, ameliorated	WT + MO1-irf8	bacterial treatment by injection: Salmonella enterica subsp. enterica serovar Typhimurium	Fig. 2 from Hall et al., 2014

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Citations

Include unpublished citations

Demy, D.L., Touret, A.L., Lancino, M., Tauzin, M., Capuana, L., Pierre, C., Herbomel, P. (2022) Trim33 conditions the lifespan of primitive macrophages and onset of definitive macrophage production. Development (Cambridge, England). 149(18):
Zhang, X., Yang, Y., Wei, Y., Zhao, Q., Lou, X. (2022) Blf and drl cluster synergistically regulate cell fate commitment during zebrafish primitive hematopoiesis. Development (Cambridge, England). 149(24)
Buchan, K.D., van Gent, M., Prajsnar, T.K., Ogryzko, N.V., de Jong, N.W.M., Kolata, J., Foster, S.J., van Strijp, J.A.G., Renshaw, S.A. (2021) Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model. Journal of Cell Science. 134(5):
Campbell, C.A., Fursova, O., Cheng, X., Snella, E., McCune, A., Li, L., Solchenberger, B., Schmid, B., Sahoo, D., Morton, M., Traver, D., Espín-Palazón, R. (2021) A zebrafish model of granulin deficiency reveals essential roles in myeloid cell differentiation. Blood advances. 5:796-811
Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319
Prajsnar, T.K., Serba, J.J., Dekker, B.M., Gibson, J.F., Masud, S., Fleming, A., Johnston, S.A., Renshaw, S.A., Meijer, A.H. (2020) The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 17(4):888-902
Yang, L., Jiménez, J.A., Earley, A.M., Hamlin, V., Kwon, V., Dixon, C.T., Shiau, C.E. (2020) Drainage of inflammatory macromolecules from brain to periphery targets the liver for macrophage infiltration. eLIFE. 9:
Masud, S., Prajsnar, T.K., Torraca, V., Lamers, G.E.M., Benning, M., Van Der Vaart, M., Meijer, A.H. (2019) Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model. Autophagy. 15(5):796-812
van den Berg, M.C.W., MacCarthy-Morrogh, L., Carter, D., Morris, J., Ribeiro Bravo, I., Feng, Y., Martin, P. (2019) Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation. Cell Reports. 27:2837-2846.e4
Rosowski, E.E., Raffa, N., Knox, B.P., Golenberg, N., Keller, N.P., Huttenlocher, A. (2018) Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. PLoS pathogens. 14:e1007229

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