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ZFIN ID: ZDB-FIG-151204-2
Pagán et al., 2015 - Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment. Cell Host & Microbe   18:15-26 Full text @ Cell Host Microbe
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 5

Macrophage Depletion Caused by irf8 Deficiency Promotes Granuloma Necrosis

(A-E) Larvae from an irf8st96/+ intercross were infected via the caudal vein with ~200 tdTomato-expressing M. marinum. (A) Percentage of larvae with cording phenotype and (B) bacterial loads 3 dpi. (C) Macrophage numbers in irf8 morpholino (MO)- and mock-injected mpeg1:YFP larvae 2 dpf. (D) Bacterial cording and (E) bacterial burdens in irf8 and mock morphants 3 dpi with ~300 tdTomato-expressing M. marinum injected via the caudal vein. (B, C, E, and G) Each symbol represents individual larvae, and horizontal lines indicate means. Statistical significance was determined by Fisher’s exact test (A and D) or one-way ANOVA with Tukey’s post-test (B, C, and E). Data are representative of three (A-D) experiments.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
w200Tg + MO1-irf8 control Long-pec macrophage decreased amount, abnormal
ZFIN wishes to thank the journal Cell Host & Microbe for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Cell Host Microbe