ZFIN ID: ZDB-GENE-040718-367
Gene Name: interferon regulatory factor 8
Gene Symbol: irf8    Nomenclature History

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Previous Name: zgc:92252

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in microglia development; regulation of macrophage differentiation; and regulation of neutrophil differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in brain; eye; hematopoietic cell; hematopoietic system; and yolk. Orthologous to human IRF8 (interferon regulatory factor 8).
Genome Resources: Alliance (1),  Gene:436895 (1),  Ensembl(GRCz11):ENSDARG00000056407 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cq47 Small Deletion Unknown Missense TALEN
cq48 Small Deletion Unknown Premature Stop TALEN
ka90 Unknown Unknown Unknown CRISPR
la013258Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st95 Small Deletion Unknown Frameshift TALEN
  • European Zebrafish Resource Center (EZRC) (order this)
  • st96 Small Deletion Unknown Frameshift TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-irf8 1
    MO1-irf8 N/A 29
    MO2-irf8 N/A 8
    TALEN1-irf8 1
    TALEN2-irf8 1
    DISEASE ASSOCIATED WITH irf8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Immunodeficiency 32A, mycobacteriosis, autosomal dominant 614893
    Immunodeficiency 32B, monocyte and dendritic cell deficiency, autosomal recessive 226990
    DISEASE ASSOCIATED WITH irf8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemopoiesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001346 Interferon regulatory factor DNA-binding domain
    Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
    Homologous_superfamily IPR017855 SMAD-like domain superfamily
    Domain IPR019471 Interferon regulatory factor-3
    Conserved_site IPR019817 Interferon regulatory factor, conserved site
    Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
    Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irf8-201 (1)    Ensembl 1767
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irf8
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:MYC-irf8) hsp70l irf8 Danio rerio 1 3
    MARKER RELATIONSHIPS
    irf8 Contained in: [BAC] DKEYP-77B5 (1)
    irf8 Encodes: [cDNA] MGC:92252 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002622 (1) 1738 bp
    Genomic GenBank:BX890541 (1) 94449 bp
    Select Tool
    Polypeptide UniProtKB:Q6DHK7 (1) 423 aa
    Sequence Information (all 9)
    ORTHOLOGY for irf8 ( Chr: 18 )
    CITATIONS (87)