Gene
irf8
- ID
- ZDB-GENE-040718-367
- Name
- interferon regulatory factor 8
- Symbol
- irf8 Nomenclature History
- Previous Names
-
- zgc:92252
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in microglia development; regulation of macrophage differentiation; and regulation of neutrophil differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in brain; eye; hematopoietic cell; hematopoietic system; and yolk. Orthologous to human IRF8 (interferon regulatory factor 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 26 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 32A | Alliance | Immunodeficiency 32A, mycobacteriosis, autosomal dominant | 614893 |
| immunodeficiency 32B | Alliance | Immunodeficiency 32B, monocyte and dendritic cell deficiency, autosomal recessive | 226990 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019817 | Interferon regulatory factor, conserved site |
| Domain | IPR001346 | Interferon regulatory factor, DNA-binding domain |
| Domain | IPR019471 | Interferon regulatory factor-3 |
| Homologous_superfamily | IPR008984 | SMAD/FHA domain superfamily |
| Homologous_superfamily | IPR017855 | SMAD-like domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Interferon regulatory factor-3 | Interferon regulatory factor, conserved site | Interferon regulatory factor, DNA-binding domain | SMAD/FHA domain superfamily | SMAD-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6DHK7
|
423 |
Interactions and Pathways
No data available
Plasmids
No data available