Gene

irf8

ID
ZDB-GENE-040718-367
Name
interferon regulatory factor 8
Symbol
irf8 Nomenclature History
Previous Names
  • zgc:92252
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in microglia development; regulation of macrophage differentiation; and regulation of neutrophil differentiation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in brain; eye; hematopoietic cell; hematopoietic system; and yolk. Orthologous to human IRF8 (interferon regulatory factor 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
21 figures from 13 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With irf8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 32A Alliance Immunodeficiency 32A, mycobacteriosis, autosomal dominant 614893
immunodeficiency 32B Alliance Immunodeficiency 32B, monocyte and dendritic cell deficiency, autosomal recessive 226990
Associated With irf8 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019817 Interferon regulatory factor, conserved site
Domain IPR001346 Interferon regulatory factor DNA-binding domain
Domain IPR019471 Interferon regulatory factor-3
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Interferon regulatory factor-3 Interferon regulatory factor, conserved site Interferon regulatory factor DNA-binding domain SMAD/FHA domain superfamily SMAD-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q6DHK7 423
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations