FIGURE

Fig. 6

ID

ZDB-FIG-260311-88

Publication

Barreiro-Docío et al., 2026 - Loss-of-function mutations in the melanocortin-2-receptor (mc2r) lead to skin hyperpigmentation in teleost fish

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Fig. 6

Gene expression analysis and visualization of potential marker genes in WT pigment cell clusters. (A) Proportion of cells in WT skin expressing a specific set of genes within each pigment cell cluster. “Neither” denotes the proportion of cells in the cluster that do not meet the minimum threshold for the expression of selected genes. (B) Uniform manifold approximation and projection (UMAP) visualization of pigment cell clusters from WT fish. The data are represented by dots, each corresponding to a single cell, with cells expressing specific genes or coexpressing several genes color coded. (C) Fold change values of differential expression between the WT and the mc2r^KO mutant for marker genes identified in each pigment cell type. A negative fold change value indicates overexpression in the WT, whereas positive values denote overexpression in the mc2r^KO mutant. All the genes displayed a p value of less than 0.05.

Expression Data

Genes:	adssl alx4b aox5 bco2b bscl2l csnk1a1 foxd3 mlpha pah pax7b plin6 pmela slc2a15a sox10 tpd52l1 tyr tyrp1b zic2a
Fish:	TU mc2r^iim23/iim23 (TU)
Anatomical Terms:	integument iridophore integument melanocyte integument xanthophore
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mc2r^iim23/iim23 (TU)
Observed In:	integument iridophore integument melanocyte integument xanthophore
Stage:	Adult

Phenotype Detail

Acknowledgments

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