Gene
alx4b
- ID
- ZDB-GENE-050208-140
- Name
- ALX homeobox 4b
- Symbol
- alx4b Nomenclature History
- Previous Names
-
- im:7142878
- si:ch73-220n21.1
- zgc:162606 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; optic vesicle; pharyngeal arch; and swim bladder bud. Human ortholog(s) of this gene implicated in colorectal cancer; craniosynostosis; frontonasal dysplasia 2; hepatocellular carcinoma; and parietal foramina. Orthologous to human ALX4 (ALX homeobox 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142878 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| frontonasal dysplasia 2 | Alliance | Frontonasal dysplasia 2 | 613451 |
| parietal foramina | Alliance | Parietal foramina 2 | 609597 |
| {Craniosynostosis 5, susceptibility to} | 615529 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | OAR domain | Paired Homeobox Transcription Factors |
|---|---|---|---|
|
UniProtKB:A0A2R8RTN2
|
259 |
Interactions and Pathways
No data available
Plasmids
No data available