Gene
foxd3
- ID
- ZDB-GENE-980526-143
- Name
- forkhead box D3
- Symbol
- foxd3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within several processes, including iridophore differentiation; negative regulation of macromolecule biosynthetic process; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Human ortholog(s) of this gene implicated in vitiligo. Orthologous to human FOXD3 (forkhead box D3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 202 figures from 150 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 15 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct110aGt | Transgenic insertion | Unknown | Unknown | DNA | |
| ct110aRGt | Transgenic insertion | Unknown | Unknown | DNA | |
| ihb666 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| ihb667 | Allele with one insertion | Unknown | Unknown | CRISPR | |
| m188 | unknown | Unknown | Unknown | ENU | |
| sa174 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa20726 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zdf10 | Allele with one deletion | Unknown | Frameshift, Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Autoimmune disease, susceptibility to, 1} | 607836 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR047392 | Forkhead box protein D3, forkhead domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box domain-containing protein | Forkhead box protein D3, forkhead domain | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R5S7 | InterPro | 371 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(foxd3:EGFP) |
|
| 1 | (4) | |
| Tg(foxd3:GFP) |
|
| 3 | (100) | |
| TgBAC(foxd3:AVI-2A-Citrine) |
|
| 1 | (2) | |
| TgBAC(foxd3:EGFP) |
|
| 1 | Cooper et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-148H10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111934 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131290 (1) | 1799 nt | ||
| Genomic | GenBank:BX664614 (1) | 184225 nt | ||
| Polypeptide | UniProtKB:F1R5S7 (1) | 371 aa |
- Niu, X., Zhang, F., Gu, W., Zhang, B., Chen, X. (2024) FBLN2 is associated with Goldenhar syndrome and is essential for cranial neural crest cell development. Annals of the New York Academy of Sciences. 1537(1):113-128
- Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
- Sun, L., Ping, L., Fan, X., Fan, Y., Zhang, B., Chen, X. (2024) amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. International Journal of Molecular Sciences. 25(2):
- Williams, A.L., Bohnsack, B.L. (2024) Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish. Cells. 13(17):
- Faucz, F.R., Horvath, A.D., Assié, G., Almeida, M.Q., Szarek, E., Boikos, S., Angelousi, A., Levy, I., Maria, A.G., Chitnis, A., Antonescu, C., Claus, R., Bertherat, J., Plass, C., Eng, C., Stratakis, C.A. (2023) Embryonic stem cell factor FOXD3 (Genesis) defects in gastrointestinal stromal tumors. Endocrine-related cancer. 30(10):
- Katkat, E., Demirci, Y., Heger, G., Karagulle, D., Papatheodorou, I., Brazma, A., Ozhan, G. (2023) Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells. Frontiers in cell and developmental biology. 11:12979101297910
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Yang, S., Xu, X., Yin, Z., Liu, Y., Wang, H., Guo, J., Wang, F., Bao, Y., Zhang, T., Sun, S. (2023) nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling. Heliyon. 9:e21915e21915
- Yu, E.P.Y., Saxena, V., Perin, S., Ekker, M. (2023) Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology. Biomolecules. 13(9):
- Alhashem, Z., Feldner-Busztin, D., Revell, C., Alvarez-Garcillan Portillo, M., Camargo-Sosa, K., Richardson, J., Rocha, M., Gauert, A., Corbeaux, T., Milanetto, M., Argenton, F., Tiso, N., Kelsh, R., Prince, V.E., Bentley, K., Linker, C. (2022) Notch controls the cell cycle to define leader versus follower identities during collective cell migration. eLIFE. 11:
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