Gene

foxd3

ID

ZDB-GENE-980526-143

Name

forkhead box D3

Symbol

foxd3 Nomenclature History

Previous Names

fkd-6 (1)
fkd6 (1)
fkh6
forkhead-6
mother superior (2)
zgc:111934

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Exhibits DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including iridophore differentiation; nervous system development; and neural crest cell migration. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in vitiligo. Is expressed in several structures, including mesoderm; nervous system; neural crest; neural keel; and neural plate. Orthologous to human FOXD3 (forkhead box D3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

199 figures from 147 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 23 figures from 15 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With foxd3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Autoimmune disease, susceptibility to, 1}	607836

Associated With foxd3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018122	Fork head domain conserved site1
Conserved_site	IPR030456	Fork head domain conserved site 2
Domain	IPR001766	Fork head domain
Domain	IPR047392	Forkhead box protein D3, forkhead domain
Family	IPR050211	Forkhead box domain-containing protein
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily