Gene
mlpha
- ID
- ZDB-GENE-050208-724
- Name
- melanophilin a
- Symbol
- mlpha Nomenclature History
- Previous Names
-
- mlphb
- si:ch211-186m12.3 (1)
- zgc:154096
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity and myosin binding activity. Acts upstream of or within pigment granule dispersal. Predicted to be active in cortical actin cytoskeleton. Is expressed in melanocyte. Human ortholog(s) of this gene implicated in Griscelli syndrome type 3. Orthologous to human MLPH (melanophilin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144073 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Sheets et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-mlpha | DiNapoli et al., 2020 | |
| MO1-mlpha | N/A | Sheets et al., 2007 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Griscelli syndrome type 3 | Alliance | Griscelli syndrome, type 3 | 609227 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006788 | Rab effector MyRIP/Melanophilin |
| Domain | IPR010911 | Rab-binding domain |
| Domain | IPR037442 | Melanophilin, FYVE-related domain |
| Domain | IPR041282 | FYVE-type zinc finger |
| Family | IPR051745 | Intracellular Transport Effector |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | FYVE-type zinc finger | Intracellular Transport Effector | Melanophilin, FYVE-related domain | Rab-binding domain | Rab effector MyRIP/Melanophilin | Zinc finger, FYVE/PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q05AI5 | InterPro | 503 | |||||||
| UniProtKB:A0A8M2BGK5 | InterPro | 575 | |||||||
| UniProtKB:E7F2P6 | InterPro | 518 | |||||||
| UniProtKB:A0AB32TPU6 | InterPro | 531 | |||||||
| UniProtKB:A0AB32TPU8 | InterPro | 546 | |||||||
| UniProtKB:A0A8M2BFZ3 | InterPro | 603 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-186M12 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7144073 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:154096 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079679 (1) | 2131 nt | ||
| Genomic | GenBank:BX649631 (1) | 168355 nt | ||
| Polypeptide | UniProtKB:A0A8M2BFZ3 (1) | 603 aa |
- Jang, H.S., Chen, Y., Ge, J., Wilkening, A.N., Hou, Y., Lee, H.J., Choi, Y.R., Lowdon, R.F., Xing, X., Li, D., Kaufman, C.K., Johnson, S.L., Wang, T. (2021) Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish. Genome biology. 22:282
- DiNapoli, S.E., Martinez-McFaline, R., Gribbin, C.K., Wrighton, P.J., Balgobin, C.A., Nelson, I., Leonard, A., Maskin, C.R., Shwartz, A., Quenzer, E.D., Mailhiot, D., Kao, C., McConnell, S.C., de Jong, J.L.O., Goessling, W., Houvras, Y. (2020) Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic acids research. 48(7):e38
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
- Allen, J.R., Skeath, J.B., Johnson, S.L. (2019) Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish. Genetics. 213(2):555-566
- Allen, J.R., Skeath, J.B., Johnson, S.L. (2019) GABA-A receptor and mitochondrial TSPO signaling act in parallel to regulate melanocyte stem cell quiescence in larval zebrafish. Pigment cell & melanoma research. 33(3):416-425
- Tobia, C., Chiodelli, P., Barbieri, A., Buraschi, S., Ferrari, E., Mitola, S., Borsani, G., Guerra, J., Presta, M. (2019) Atypical Chemokine Receptor 3 Generates Guidance Cues for CXCL12-Mediated Endothelial Cell Migration. Frontiers in immunology. 10:1092
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- O'Reilly-Pol, T., and Johnson, S.L. (2013) Kit signaling is involved in melanocyte stem cell fate decisions in zebrafish embryos. Development (Cambridge, England). 140(5):996-1002
- Tryon, R.C., Higdon, C.W., and Johnson, S.L. (2011) Lineage relationship of direct-developing melanocytes and melanocyte stem cells in the zebrafish. PLoS One. 6(6):e21010
- Tu, S., and Johnson, S.L. (2010) Clonal analyses reveal roles of organ founding stem cells, melanocyte stem cells and melanoblasts in establishment, growth and regeneration of the adult zebrafish fin. Development (Cambridge, England). 137(23):3931-3939
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